4n9g - Revision history

OCA at 16:50, 20 September 2023

2023-09-20T16:50:06Z

←Older revision		Revision as of 16:50, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [https://pdbe.org/4n9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [https://www.ebi.ac.uk/pdbsum/4n9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9g ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [https://pdbe.org/4n9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [https://www.ebi.ac.uk/pdbsum/4n9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:16, 11 January 2023

2023-01-11T08:16:01Z

←Older revision		Revision as of 08:16, 11 January 2023
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	==Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9==		==Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9==
-	<StructureSection load='4n9g' size='340' side='right' caption='[[4n9g]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4n9g' size='340' side='right'caption='[[4n9g]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~] and [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N9G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9G FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Computationally designed variant of Ribosomal Recycling Factor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [https://pdbe.org/4n9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [https://www.ebi.ac.uk/pdbsum/4n9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9g ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [~~http~~://pdbe.org/4n9g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n9g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9g ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 4n9g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n9g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Macmu~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Synthetic construct sequences~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: ~~Carrico, C T.D~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Strong, R K~~]]	+	[[Category: Carrico CTD]]
-	[[Category: ~~Antibody]]~~	+	[[Category: Strong RK]]
-	~~[[Category: Epitope scaffold]]~~	+
-	~~[[Category: Hairpin]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 21:17, 11 August 2016

2016-08-11T21:17:48Z

←Older revision		Revision as of 21:17, 11 August 2016
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		+
	==Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9==		==Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9==
	<StructureSection load='4n9g' size='340' side='right' caption='[[4n9g]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4n9g' size='340' side='right' caption='[[4n9g]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9G FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9G FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Computationally designed variant of Ribosomal Recycling Factor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Computationally designed variant of Ribosomal Recycling Factor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [http://www.ebi.ac.uk/pdbsum/4n9g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [http://pdbe.org/4n9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [http://www.ebi.ac.uk/pdbsum/4n9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n9g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:46, 5 January 2015

2015-01-05T09:46:33Z

←Older revision		Revision as of 09:46, 5 January 2015
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-	~~{{STRUCTURE_4n9g\| PDB=4n9g \| SCENE= }}~~	+	==Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9==
-	===Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9===	+	<StructureSection load='4n9g' size='340' side='right' caption='[[4n9g]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24499818}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n9g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9G FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Computationally designed variant of Ribosomal Recycling Factor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32630 SYNTHETIC CONSTRUCT sequences])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9g RCSB], [http://www.ebi.ac.uk/pdbsum/4n9g PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antibodies have been identified for several such cases. Hence, new vaccine design methods to induce epitope-specific neutralizing antibodies are needed. Here we show, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies. These scaffolds represent promising leads for the research and development of a human respiratory syncytial virus vaccine needed to protect infants, young children and the elderly. More generally, the results provide proof of principle for epitope-focused and scaffold-based vaccine design, and encourage the evaluation and further development of these strategies for a variety of other vaccine targets, including antigenically highly variable pathogens such as human immunodeficiency virus and influenza.

-	~~==About this Structure==~~	+	Proof of principle for epitope-focused vaccine design.,Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, Serra AM, Adachi Y, Holmes MA, Li Y, Klevit RE, Graham BS, Wyatt RT, Baker D, Strong RK, Crowe JE, Johnson PR, Schief WR Nature. 2014 Feb 5. doi: 10.1038/nature12966. PMID:24499818<ref>PMID:24499818</ref>
-	~~[[4n9g]] is a 12 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4N9G OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024499818</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Carrico, C T.D.]]	+	== References ==
-	[[Category: Strong, R K.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Macmu]]
		+	[[Category: Synthetic construct sequences]]
		+	[[Category: Carrico, C T.D]]
		+	[[Category: Strong, R K]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Epitope scaffold]]		[[Category: Epitope scaffold]]
	[[Category: Hairpin]]		[[Category: Hairpin]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 08:58, 19 March 2014

2014-03-19T08:58:06Z

←Older revision		Revision as of 08:58, 19 March 2014
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	{{STRUCTURE_4n9g\| PDB=4n9g \| SCENE= }}		{{STRUCTURE_4n9g\| PDB=4n9g \| SCENE= }}
	===Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9===		===Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9===
		+	{{ABSTRACT_PUBMED_24499818}}

	==About this Structure==		==About this Structure==
	[[4n9g]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA].		[[4n9g]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024499818</ref><references group="xtra"/><references/>
	[[Category: Carrico, C T.D.]]		[[Category: Carrico, C T.D.]]
	[[Category: Strong, R K.]]		[[Category: Strong, R K.]]

OCA at 05:22, 13 February 2014

2014-02-13T05:22:52Z

←Older revision		Revision as of 05:22, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4n9g\| PDB=4n9g \| SCENE= }}
		+	===Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9===

-	~~The entry~~ 4n9g is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4n9g]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9G OCA].
-	~~Authors~~: Carrico, C.T.D., Strong, R.K.	+	[[Category: Carrico, C T.D.]]
-		+	[[Category: Strong, R K.]]
-	~~Description~~: ~~Crystal Structure of a Computationally Designed RSV-Presenting~~ Epitope ~~Scaffold And Its Elicited Antibody 17HD9~~	+	[[Category: Antibody]]
		+	[[Category: Epitope scaffold]]
		+	[[Category: Hairpin]]
		+	[[Category: Immune system]]

OCA: Protected "4n9g" [edit=sysop:move=sysop]

2013-11-06T07:04:47Z

Protected "4n9g" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:04, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4n9g is ON HOLD Authors: Carrico, C.T.D., Strong, R.K. Description: Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold...

2013-11-06T07:04:45Z

New page: '''Unreleased structure''' The entry 4n9g is ON HOLD Authors: Carrico, C.T.D., Strong, R.K. Description: Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold...

New page

'''Unreleased structure'''

The entry 4n9g is ON HOLD

Authors: Carrico, C.T.D., Strong, R.K.

Description: Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9