4njl - Revision history

OCA at 16:58, 20 September 2023

2023-09-20T16:58:14Z

←Older revision		Revision as of 16:58, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [https://pdbe.org/4njl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [https://www.ebi.ac.uk/pdbsum/4njl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4njl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [https://pdbe.org/4njl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [https://www.ebi.ac.uk/pdbsum/4njl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4njl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:31, 11 January 2023

2023-01-11T08:31:16Z

←Older revision		Revision as of 08:31, 11 January 2023
Line 3:		Line 3:
	<StructureSection load='4njl' size='340' side='right'caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4njl' size='340' side='right'caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mers Mers~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [~~http~~://pdbe.org/4njl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4njl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4njl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [https://pdbe.org/4njl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [https://www.ebi.ac.uk/pdbsum/4njl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4njl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/R9UQ53_MERS R9UQ53_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mers~~]]	+	[[Category: Middle East respiratory syndrome-related coronavirus]]
-	[[Category: Jiang, S]]	+	[[Category: Jiang S]]
-	[[Category: Lu, L]]	+	[[Category: Lu L]]
-	[[Category: Qin, L]]	+	[[Category: Qin L]]
-	[[Category: Ye, S]]	+	[[Category: Ye S]]
-	[[Category: Zhang, R]]	+	[[Category: Zhang R]]
-	[[Category: Zhu, Y]]	+	[[Category: Zhu Y]]
-	~~[[Category: Coronavirus]]~~	+
-	~~[[Category: Fusion core]]~~	+
-	~~[[Category: Fusion inhibitor]]~~	+
-	~~[[Category: Mers-cov]]~~	+
-	~~[[Category: Six-helix-bundle]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:26, 10 April 2019

2019-04-10T08:26:28Z

←Older revision		Revision as of 08:26, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core==		==Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core==
-	<StructureSection load='4njl' size='340' side='right' caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4njl' size='340' side='right'caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJL FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mers]]		[[Category: Mers]]
	[[Category: Jiang, S]]		[[Category: Jiang, S]]

OCA at 18:55, 11 August 2016

2016-08-11T18:55:06Z

←Older revision		Revision as of 18:55, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core==		==Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core==
	<StructureSection load='4njl' size='340' side='right' caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4njl' size='340' side='right' caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [http://www.ebi.ac.uk/pdbsum/4njl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [http://pdbe.org/4njl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [http://www.ebi.ac.uk/pdbsum/4njl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4njl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4njl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:23, 5 January 2015

2015-01-05T09:23:54Z

←Older revision		Revision as of 09:23, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4njl\| PDB=4njl \| SCENE= }}~~	+	==Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core==
-	===Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core===	+	<StructureSection load='4njl' size='340' side='right' caption='[[4njl]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24473083}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4njl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4njl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4njl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4njl RCSB], [http://www.ebi.ac.uk/pdbsum/4njl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel human coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV), has caused outbreaks of a SARS-like illness with high case fatality rate. The reports of its person-to-person transmission through close contacts have raised a global concern about its pandemic potential. Here we characterize the six-helix bundle fusion core structure of MERS-CoV spike protein S2 subunit by X-ray crystallography and biophysical analysis. We find that two peptides, HR1P and HR2P, spanning residues 998-1039 in HR1 and 1251-1286 in HR2 domains, respectively, can form a stable six-helix bundle fusion core structure, suggesting that MERS-CoV enters into the host cell mainly through membrane fusion mechanism. HR2P can effectively inhibit MERS-CoV replication and its spike protein-mediated cell-cell fusion. Introduction of hydrophilic residues into HR2P results in significant improvement of its stability, solubility and antiviral activity. Therefore, the HR2P analogues have good potential to be further developed into effective viral fusion inhibitors for treating MERS-CoV infection.

-	~~==About this~~ Structure==	+	Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor.,Lu L, Liu Q, Zhu Y, Chan KH, Qin L, Li Y, Wang Q, Chan JF, Du L, Yu F, Ma C, Ye S, Yuen KY, Zhang R, Jiang S Nat Commun. 2014 Jan 28;5:3067. doi: 10.1038/ncomms4067. PMID:24473083<ref>PMID:24473083</ref>
-	~~[[4njl]] is a 1 chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NJL OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024473083</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Jiang, S.]]	+	== References ==
-	[[Category: Lu, L.]]	+	<references/>
-	[[Category: Qin, L.]]	+	__TOC__
-	[[Category: Ye, S.]]	+	</StructureSection>
-	[[Category: Zhang, R.]]	+	[[Category: Mers]]
-	[[Category: Zhu, Y.]]	+	[[Category: Jiang, S]]
		+	[[Category: Lu, L]]
		+	[[Category: Qin, L]]
		+	[[Category: Ye, S]]
		+	[[Category: Zhang, R]]
		+	[[Category: Zhu, Y]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
	[[Category: Fusion core]]		[[Category: Fusion core]]

OCA at 17:18, 19 February 2014

2014-02-19T17:18:51Z

←Older revision		Revision as of 17:18, 19 February 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4njl\| PDB=4njl \| SCENE= }}
		+	===Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core===
		+	{{ABSTRACT_PUBMED_24473083}}

-	~~The entry~~ 4njl is ~~ON HOLD~~	+	==About this Structure==
		+	[[4njl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJL OCA].

-	~~Authors~~: ~~Zhu~~, Y., Lu, L., Qin, L., Ye, S.~~, Jiang, S.,~~ Zhang, R.	+	==Reference==
-		+	<ref group="xtra">PMID:024473083</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion~~ core	+	[[Category: Jiang, S.]]
		+	[[Category: Lu, L.]]
		+	[[Category: Qin, L.]]
		+	[[Category: Ye, S.]]
		+	[[Category: Zhang, R.]]
		+	[[Category: Zhu, Y.]]
		+	[[Category: Coronavirus]]
		+	[[Category: Fusion core]]
		+	[[Category: Fusion inhibitor]]
		+	[[Category: Mers-cov]]
		+	[[Category: Six-helix-bundle]]
		+	[[Category: Viral protein]]

OCA: Protected "4njl" [edit=sysop:move=sysop]

2013-11-20T12:59:40Z

Protected "4njl" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:59, 20 November 2013

OCA: New page: '''Unreleased structure''' The entry 4njl is ON HOLD Authors: Zhu, Y., Lu, L., Qin, L., Ye, S., Jiang, S., Zhang, R. Description: Crystal structure of middle east respiratory syndrome ...

2013-11-20T12:59:39Z

New page: '''Unreleased structure''' The entry 4njl is ON HOLD Authors: Zhu, Y., Lu, L., Qin, L., Ye, S., Jiang, S., Zhang, R. Description: Crystal structure of middle east respiratory syndrome ...

New page

'''Unreleased structure'''

The entry 4njl is ON HOLD

Authors: Zhu, Y., Lu, L., Qin, L., Ye, S., Jiang, S., Zhang, R.

Description: Crystal structure of middle east respiratory syndrome coronavirus S2 protein fusion core