4nku - Revision history

OCA at 16:58, 20 September 2023

2023-09-20T16:58:43Z

←Older revision		Revision as of 16:58, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NKU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [https://pdbe.org/4nku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [https://www.ebi.ac.uk/pdbsum/4nku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [https://pdbe.org/4nku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [https://www.ebi.ac.uk/pdbsum/4nku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nku ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:32, 11 January 2023

2023-01-11T08:32:43Z

←Older revision		Revision as of 08:32, 11 January 2023
Line 1:		Line 1:

	==Structure of Cid1 in complex with its short product ApU==		==Structure of Cid1 in complex with its short product ApU==
-	<StructureSection load='4nku' size='340' side='right' caption='[[4nku]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='4nku' size='340' side='right'caption='[[4nku]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nku]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nku]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nkt\|4nkt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [https://pdbe.org/4nku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [https://www.ebi.ac.uk/pdbsum/4nku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nku ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cid1, SPAC19D5.03 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [~~http~~://pdbe.org/4nku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nku ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CID1_SCHPO CID1_SCHPO]] Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.	+	[https://www.uniprot.org/uniprot/CID1_SCHPO CID1_SCHPO] Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Poly(A) RNA polymerase ~~protein Cid1~~\|Poly(A) ~~RNA polymerase protein Cid1]]~~	+	*[[Poly(A) RNA polymerase\|Poly(A) RNA polymerase]]
-	*[[RNA polymerase\|RNA polymerase]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cbs 356~~]]	+	[[Category: Large Structures]]
-	[[Category: Gabus, C]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: Munoz-Tello, P]]	+	[[Category: Gabus C]]
-	[[Category: Thore, S]]	+	[[Category: Munoz-Tello P]]
-	~~[[Category: Nucleotidyl tranfer domain]]~~	+	[[Category: Thore S]]
-	~~[[Category: Pap-associated domain]]~~	+
-	~~[[Category: Transferase-rna complex]]~~	+
-	~~[[Category: Utp binding~~]]	+

OCA at 17:09, 5 August 2016

2016-08-05T17:09:07Z

←Older revision		Revision as of 17:09, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Cid1 in complex with its short product ApU==		==Structure of Cid1 in complex with its short product ApU==
	<StructureSection load='4nku' size='340' side='right' caption='[[4nku]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4nku' size='340' side='right' caption='[[4nku]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nkt\|4nkt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nkt\|4nkt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cid1, SPAC19D5.03 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cid1, SPAC19D5.03 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [http://www.ebi.ac.uk/pdbsum/4nku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [http://pdbe.org/4nku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [http://www.ebi.ac.uk/pdbsum/4nku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nku ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nku" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Poly(A) RNA polymerase protein Cid1\|Poly(A) RNA polymerase protein Cid1]]
	*[[RNA polymerase\|RNA polymerase]]		*[[RNA polymerase\|RNA polymerase]]
	== References ==		== References ==

OCA at 04:18, 25 December 2014

2014-12-25T04:18:10Z

←Older revision		Revision as of 04:18, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nku\| PDB=4nku \| SCENE= }}~~	+	==Structure of Cid1 in complex with its short product ApU==
-	===Structure of Cid1 in complex with its short product ApU===	+	<StructureSection load='4nku' size='340' side='right' caption='[[4nku]], [[Resolution\|resolution]] 1.94Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24322298}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nku]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NKU FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nkt\|4nkt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cid1, SPAC19D5.03 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nku RCSB], [http://www.ebi.ac.uk/pdbsum/4nku PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CID1_SCHPO CID1_SCHPO]] Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.		[[http://www.uniprot.org/uniprot/CID1_SCHPO CID1_SCHPO]] Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The addition of uridine nucleotide by the poly(U) polymerase (PUP) enzymes has a demonstrated impact on various classes of RNAs such as microRNAs (miRNAs), histone-encoding RNAs and messenger RNAs. Cid1 protein is a member of the PUP family. We solved the crystal structure of Cid1 in complex with non-hydrolyzable UMPNPP and a short dinucleotide compound ApU. These structures revealed new residues involved in substrate/product stabilization. In particular, one of the three catalytic aspartate residues explains the RNA dependence of its PUP activity. Moreover, other residues such as residue N165 or the beta-trapdoor are shown to be critical for Cid1 activity. We finally suggest that the length and sequence of Cid1 substrate RNA influence the balance between Cid1's processive and distributive activities. We propose that particular processes regulated by PUPs require the enzymes to switch between the two types of activity as shown for the miRNA biogenesis where PUPs can either promote DICER cleavage via short U-tail or trigger miRNA degradation by adding longer poly(U) tail. The enzymatic properties of these enzymes may be critical for determining their particular function in vivo.
		+
		+	A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure.,Munoz-Tello P, Gabus C, Thore S Nucleic Acids Res. 2013 Dec 9. PMID:24322298<ref>PMID:24322298</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4nku]] is~~ a ~~4 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NKU OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024322298</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[RNA polymerase\|RNA polymerase]]
-	[[Category: Gabus, C.]]	+	== References ==
-	[[Category: Munoz-Tello, P.]]	+	<references/>
-	[[Category: Thore, S.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Cbs 356]]
		+	[[Category: Gabus, C]]
		+	[[Category: Munoz-Tello, P]]
		+	[[Category: Thore, S]]
	[[Category: Nucleotidyl tranfer domain]]		[[Category: Nucleotidyl tranfer domain]]
	[[Category: Pap-associated domain]]		[[Category: Pap-associated domain]]
	[[Category: Transferase-rna complex]]		[[Category: Transferase-rna complex]]
	[[Category: Utp binding]]		[[Category: Utp binding]]

OCA at 06:57, 15 January 2014

2014-01-15T06:57:03Z

←Older revision		Revision as of 06:57, 15 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4nku\| PDB=4nku \| SCENE= }}		{{STRUCTURE_4nku\| PDB=4nku \| SCENE= }}
	===Structure of Cid1 in complex with its short product ApU===		===Structure of Cid1 in complex with its short product ApU===
		+	{{ABSTRACT_PUBMED_24322298}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4nku]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA].		[[4nku]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024322298</ref><references group="xtra"/><references/>
	[[Category: Gabus, C.]]		[[Category: Gabus, C.]]
	[[Category: Munoz-Tello, P.]]		[[Category: Munoz-Tello, P.]]

OCA at 10:43, 18 December 2013

2013-12-18T10:43:16Z

←Older revision		Revision as of 10:43, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nku\| PDB=4nku \| SCENE= }}
		+	===Structure of Cid1 in complex with its short product ApU===

-	~~The entry 4nku is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CID1_SCHPO CID1_SCHPO]] Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.

-	~~Authors~~: ~~Munoz~~-~~Tello, P~~., Gabus, C., Thore, S.	+	==About this Structure==
-		+	[[4nku]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKU OCA].
-	~~Description~~: ~~A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product~~-~~bound crystal structure~~	+	[[Category: Gabus, C.]]
		+	[[Category: Munoz-Tello, P.]]
		+	[[Category: Thore, S.]]
		+	[[Category: Nucleotidyl tranfer domain]]
		+	[[Category: Pap-associated domain]]
		+	[[Category: Transferase-rna complex]]
		+	[[Category: Utp binding]]

OCA: Protected "4nku" [edit=sysop:move=sysop]

2013-11-20T13:01:16Z

Protected "4nku" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:01, 20 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nku is ON HOLD Authors: Munoz-Tello, P., Gabus, C., Thore, S. Description: A critical switch in the enzymatic properties of the Cid1 protein decip...

2013-11-20T13:01:16Z

New page: '''Unreleased structure''' The entry 4nku is ON HOLD Authors: Munoz-Tello, P., Gabus, C., Thore, S. Description: A critical switch in the enzymatic properties of the Cid1 protein decip...

New page

'''Unreleased structure'''

The entry 4nku is ON HOLD

Authors: Munoz-Tello, P., Gabus, C., Thore, S.

Description: A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure