4nmp - Revision history

OCA at 17:00, 20 September 2023

2023-09-20T17:00:10Z

←Older revision		Revision as of 17:00, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [https://pdbe.org/4nmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [https://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [https://pdbe.org/4nmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [https://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:35, 11 January 2023

2023-01-11T08:35:17Z

←Older revision		Revision as of 08:35, 11 January 2023
Line 3:		Line 3:
	<StructureSection load='4nmp' size='340' side='right'caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4nmp' size='340' side='right'caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [https://pdbe.org/4nmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [https://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">GOPC, CAL, FIG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [~~http~~://pdbe.org/4nmp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>	+	[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>	+	[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amacher~~, J F~~]]	+	[[Category: Amacher JF]]
-	[[Category: Madden~~, D R]]~~	+	[[Category: Madden DR]]
-	~~[[Category: Cal]]~~	+
-	~~[[Category: Cftr]]~~	+
-	~~[[Category: Cftr associated ligand]]~~	+
-	~~[[Category: Fig]]~~	+
-	~~[[Category: Gopc]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Pdz-peptide complex]]~~	+
-	~~[[Category: Pist]]~~	+
-	~~[[Category: Protein transport-inhibitor complex~~]]	+

OCA at 08:49, 10 April 2019

2019-04-10T08:49:30Z

←Older revision		Revision as of 08:49, 10 April 2019
Line 1:		Line 1:

	==CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)==		==CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)==
-	<StructureSection load='4nmp' size='340' side='right' caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4nmp' size='340' side='right'caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GOPC, CAL, FIG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://pdbe.org/4nmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://pdbe.org/4nmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amacher, J F]]		[[Category: Amacher, J F]]
	[[Category: Madden, D R]]		[[Category: Madden, D R]]

OCA at 17:21, 11 August 2016

2016-08-11T17:21:23Z

←Older revision		Revision as of 17:21, 11 August 2016
Line 1:		Line 1:
		+
	==CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)==		==CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)==
	<StructureSection load='4nmp' size='340' side='right' caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4nmp' size='340' side='right' caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://pdbe.org/4nmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nmp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:38, 20 January 2015

2015-01-20T11:38:40Z

←Older revision		Revision as of 11:38, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>		[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amacher, J F.]]	+	[[Category: Amacher, J F]]
-	[[Category: Madden, D R.]]	+	[[Category: Madden, D R]]
	[[Category: Cal]]		[[Category: Cal]]
	[[Category: Cftr]]		[[Category: Cftr]]

OCA at 00:16, 2 October 2014

2014-10-02T00:16:52Z

←Older revision		Revision as of 00:16, 2 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)==
		+	<StructureSection load='4nmp' size='340' side='right' caption='[[4nmp]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nmo\|4nmo]], [[4nmq\|4nmq]], [[4nmr\|4nmr]], [[4nms\|4nms]], [[4nmt\|4nmt]], [[4nmv\|4nmv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nmp RCSB], [http://www.ebi.ac.uk/pdbsum/4nmp PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PDZ domains are protein-protein interaction modules that coordinate multiple signaling and trafficking pathways in the cell and that include active therapeutic targets for diseases such as cancer, cystic fibrosis, and addiction. Our previous work characterized a PDZ interaction that restricts the apical membrane half-life of the cystic fibrosis transmembrane conductance regulator (CFTR). Using iterative cycles of peptide-array and solution-binding analysis, we targeted the PDZ domain of the CFTR-Associated Ligand (CAL), and showed that an engineered peptide inhibitor rescues cell-surface expression of the most common CFTR disease mutation DeltaF508. Here, we present a series of scaffolds containing chemically modifiable side chains at all non-motif positions along the CAL PDZ domain binding cleft. Concordant equilibrium dissociation constants were determined in parallel by fluorescence polarization, isothermal titration calorimetry, and surface plasmon resonance techniques, confirming robust affinity for each scaffold and revealing an enthalpically driven mode of inhibitor binding. Structural studies demonstrate a conserved binding mode for each peptide, opening the possibility of combinatorial modification. Finally, we diversified one of our peptide scaffolds with halogenated substituents that yielded modest increases in binding affinity. Overall, this work validates our approach and provides a stereochemical foundation for further CAL inhibitor design and screening.

-	~~The entry 4nmp is ON HOLD until Paper Publication~~	+	Chemically Modified Peptide Scaffolds Target the CFTR-Associated Ligand PDZ Domain.,Amacher JF, Zhao R, Spaller MR, Madden DR PLoS One. 2014 Aug 19;9(8):e103650. doi: 10.1371/journal.pone.0103650., eCollection 2014. PMID:25136860<ref>PMID:25136860</ref>

-	~~Authors~~: Amacher, J.F., Madden, D.R.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~CFTR Associated Ligand (CAL) PDZ~~ domain ~~bound to peptide iCAL36(Ac-K~~-~~3) (ANSRWP~~[Ac-K]~~SII)~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Amacher, J F.]]
		+	[[Category: Madden, D R.]]
		+	[[Category: Cal]]
		+	[[Category: Cftr]]
		+	[[Category: Cftr associated ligand]]
		+	[[Category: Fig]]
		+	[[Category: Gopc]]
		+	[[Category: Pdz domain]]
		+	[[Category: Pdz-peptide complex]]
		+	[[Category: Pist]]
		+	[[Category: Protein transport-inhibitor complex]]

OCA at 06:50, 4 December 2013

2013-12-04T06:50:50Z

←Older revision		Revision as of 06:50, 4 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nmp is ON HOLD	+	The entry 4nmp is ON HOLD until Paper Publication

	Authors: Amacher, J.F., Madden, D.R.		Authors: Amacher, J.F., Madden, D.R.

	Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)		Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)

OCA: Protected "4nmp" [edit=sysop:move=sysop]

2013-11-27T09:51:19Z

Protected "4nmp" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:51, 27 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nmp is ON HOLD Authors: Amacher, J.F., Madden, D.R. Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[A...

2013-11-27T09:51:18Z

New page: '''Unreleased structure''' The entry 4nmp is ON HOLD Authors: Amacher, J.F., Madden, D.R. Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[A...

New page

'''Unreleased structure'''

The entry 4nmp is ON HOLD

Authors: Amacher, J.F., Madden, D.R.

Description: CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36(Ac-K-3) (ANSRWP[Ac-K]SII)