4nzi - Revision history

OCA at 12:36, 1 March 2024

2024-03-01T12:36:37Z

←Older revision		Revision as of 12:36, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [https://pdbe.org/4nzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [https://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [https://pdbe.org/4nzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [https://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>		[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Neuroglobin is a member of the globin family involved in neuroprotection; it is primarily expressed in the brain and retina of vertebrates. Neuroglobin belongs to the heterogeneous group of hexacoordinate globins that have evolved in animals, plants and bacteria, endowed with the capability of reversible intramolecular coordination, allowing the binding of small gaseous ligands (O2, NO and CO). In a unique fashion among haemoproteins, ligand-binding events in neuroglobin are dependent on the sliding of the haem itself within a preformed internal cavity, as revealed by the crystal structure of its CO-bound derivative. Point mutants of the neuroglobin internal cavity have been engineered and their functional and structural characterization shows that hindering the haem displacement leads to a decrease in CO affinity, whereas reducing the cavity volume without interfering with haem sliding has negligible functional effects.
-
-	Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.,Avella G, Ardiccioni C, Scaglione A, Moschetti T, Rondinelli C, Montemiglio LC, Savino C, Giuffre A, Brunori M, Vallone B Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1640-8. doi:, 10.1107/S1399004714007032. Epub 2014 May 29. PMID:24914975<ref>PMID:24914975</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4nzi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:47, 18 January 2023

2023-01-18T08:47:46Z

←Older revision		Revision as of 08:47, 18 January 2023
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	<StructureSection load='4nzi' size='340' side='right'caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4nzi' size='340' side='right'caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [https://pdbe.org/4nzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [https://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ngb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [~~http~~://pdbe.org/4nzi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>	+	[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Avella, G]]	+	[[Category: Avella G]]
-	[[Category: Savino, C]]	+	[[Category: Savino C]]
-	[[Category: Vallone, B]]	+	[[Category: Vallone B]]
-	~~[[Category: Globin]]~~	+
-	~~[[Category: Oxygen transporter]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:36, 10 April 2019

2019-04-10T08:36:53Z

←Older revision		Revision as of 08:36, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of murine neuroglobin mutant V140W==		==Crystal structure of murine neuroglobin mutant V140W==
-	<StructureSection load='4nzi' size='340' side='right' caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4nzi' size='340' side='right'caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ngb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://pdbe.org/4nzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://pdbe.org/4nzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Avella, G]]		[[Category: Avella, G]]
	[[Category: Savino, C]]		[[Category: Savino, C]]

OCA at 20:16, 5 August 2016

2016-08-05T20:16:38Z

←Older revision		Revision as of 20:16, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of murine neuroglobin mutant V140W==		==Crystal structure of murine neuroglobin mutant V140W==
	<StructureSection load='4nzi' size='340' side='right' caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4nzi' size='340' side='right' caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://pdbe.org/4nzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nzi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neuroglobin\|Neuroglobin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:31, 25 December 2014

2014-12-25T05:31:56Z

←Older revision		Revision as of 05:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Avella, G.]]	+	[[Category: Avella, G]]
-	[[Category: Savino, C.]]	+	[[Category: Savino, C]]
-	[[Category: Vallone, B.]]	+	[[Category: Vallone, B]]
	[[Category: Globin]]		[[Category: Globin]]
	[[Category: Oxygen transporter]]		[[Category: Oxygen transporter]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 06:22, 24 September 2014

2014-09-24T06:22:34Z

←Older revision		Revision as of 06:22, 24 September 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neuroglobin is a member of the globin family involved in neuroprotection; it is primarily expressed in the brain and retina of vertebrates. Neuroglobin belongs to the heterogeneous group of hexacoordinate globins that have evolved in animals, plants and bacteria, endowed with the capability of reversible intramolecular coordination, allowing the binding of small gaseous ligands (O2, NO and CO). In a unique fashion among haemoproteins, ligand-binding events in neuroglobin are dependent on the sliding of the haem itself within a preformed internal cavity, as revealed by the crystal structure of its CO-bound derivative. Point mutants of the neuroglobin internal cavity have been engineered and their functional and structural characterization shows that hindering the haem displacement leads to a decrease in CO affinity, whereas reducing the cavity volume without interfering with haem sliding has negligible functional effects.
		+
		+	Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism.,Avella G, Ardiccioni C, Scaglione A, Moschetti T, Rondinelli C, Montemiglio LC, Savino C, Giuffre A, Brunori M, Vallone B Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1640-8. doi:, 10.1107/S1399004714007032. Epub 2014 May 29. PMID:24914975<ref>PMID:24914975</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:16, 18 June 2014

2014-06-18T08:16:04Z

←Older revision		Revision as of 08:16, 18 June 2014
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-	'''~~Unreleased structure~~'''	+	==Crystal structure of murine neuroglobin mutant V140W==
-		+	<StructureSection load='4nzi' size='340' side='right' caption='[[4nzi]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 4nzi is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZI FirstGlance]. <br>
-	~~Authors~~: Avella, G., Savino, C., Vallone, B.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1f\|1q1f]], [[4mu5\|4mu5]], [[4o1t\|4o1t]], [[4o2g\|4o2g]], [[4o35\|4o35]]</td></tr>
-	~~Description~~: ~~Crystal structure of murine neuroglobin mutant V140W~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzi RCSB], [http://www.ebi.ac.uk/pdbsum/4nzi PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Avella, G.]]
		+	[[Category: Savino, C.]]
		+	[[Category: Vallone, B.]]
		+	[[Category: Globin]]
		+	[[Category: Oxygen transporter]]
		+	[[Category: Transport protein]]

OCA at 12:09, 12 March 2014

2014-03-12T12:09:58Z

←Older revision		Revision as of 12:09, 12 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nzi is ON HOLD	+	The entry 4nzi is ON HOLD until Paper Publication

	Authors: Avella, G., Savino, C., Vallone, B.		Authors: Avella, G., Savino, C., Vallone, B.

	Description: Crystal structure of murine neuroglobin mutant V140W		Description: Crystal structure of murine neuroglobin mutant V140W

OCA: Protected "4nzi" [edit=sysop:move=sysop]

2013-12-18T09:29:10Z

Protected "4nzi" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:29, 18 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nzi is ON HOLD Authors: Avella, G., Savino, C., Vallone, B. Description: Crystal structure of murine neuroglobin mutant V140W

2013-12-18T09:29:08Z

New page: '''Unreleased structure''' The entry 4nzi is ON HOLD Authors: Avella, G., Savino, C., Vallone, B. Description: Crystal structure of murine neuroglobin mutant V140W

New page

'''Unreleased structure'''

The entry 4nzi is ON HOLD

Authors: Avella, G., Savino, C., Vallone, B.

Description: Crystal structure of murine neuroglobin mutant V140W