4o4c - Revision history

OCA at 17:07, 20 September 2023

2023-09-20T17:07:03Z

←Older revision		Revision as of 17:07, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS-A Entamoeba histolytica HM-1:IMSS-A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS-A Entamoeba histolytica HM-1:IMSS-A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [https://pdbe.org/4o4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [https://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [https://pdbe.org/4o4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [https://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:55, 18 January 2023

2023-01-18T08:55:29Z

←Older revision		Revision as of 08:55, 18 January 2023
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	<StructureSection load='4o4c' size='340' side='right'caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4o4c' size='340' side='right'caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Entamoeba_histolytica_hm~~-1:~~imss~~-a Entamoeba histolytica hm-1:~~imss~~-a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS-A Entamoeba histolytica HM-1:IMSS-A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4C FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [https://pdbe.org/4o4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [https://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI7A_103520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=885318 Entamoeba histolytica HM-1:IMSS-A])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [~~http~~://pdbe.org/4o4c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/N9UNA8_ENTH1 N9UNA8_ENTH1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Entamoeba histolytica hm-1:~~imss~~-~~a]]~~	+	[[Category: Entamoeba histolytica HM-1:IMSS-A]]
-	~~[[Category: Inositol-hexakisphosphate kinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Shears~~, S B~~]]	+	[[Category: Shears SB]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Inositol phosphate]]~~	+
-	~~[[Category: Pdkg kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:31, 10 April 2019

2019-04-10T08:31:17Z

←Older revision		Revision as of 08:31, 10 April 2019
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	==Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA==		==Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA==
-	<StructureSection load='4o4c' size='340' side='right' caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4o4c' size='340' side='right'caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica_hm-1:imss-a Entamoeba histolytica hm-1:imss-a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI7A_103520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=885318 Entamoeba histolytica HM-1:IMSS-A])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://pdbe.org/4o4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://pdbe.org/4o4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Entamoeba histolytica hm-1:imss-a]]
	[[Category: Inositol-hexakisphosphate kinase]]		[[Category: Inositol-hexakisphosphate kinase]]
		+	[[Category: Large Structures]]
	[[Category: Shears, S B]]		[[Category: Shears, S B]]
	[[Category: Wang, H]]		[[Category: Wang, H]]

OCA at 14:29, 11 August 2016

2016-08-11T14:29:07Z

←Older revision		Revision as of 14:29, 11 August 2016
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		+
	==Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA==		==Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA==
	<StructureSection load='4o4c' size='340' side='right' caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4o4c' size='340' side='right' caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://pdbe.org/4o4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o4c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:43, 5 January 2015

2015-01-05T12:43:58Z

←Older revision

Revision as of 12:43, 5 January 2015

OCA at 06:11, 9 July 2014

2014-07-09T06:11:22Z

←Older revision		Revision as of 06:11, 9 July 2014
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	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inositol trisphosphate kinases (IP3Ks) and inositol hexakisphosphate kinases (IP6Ks) each regulate specialized signalling activities by phosphorylating either InsP3 or InsP6 respectively. The molecular basis for these different kinase activities can be illuminated by a structural description of IP6K. Here we describe the crystal structure of an Entamoeba histolytica hybrid IP6K/IP3K, an enzymatic parallel to a 'living fossil'. Through molecular modelling and mutagenesis, we extrapolated our findings to human IP6K2, which retains vestigial IP3K activity. Two structural elements, an alpha-helical pair and a rare, two-turn 310 helix, together forge a substrate-binding pocket with an open clamshell geometry. InsP6 forms substantial contacts with both structural elements. Relative to InsP6, enzyme-bound InsP3 rotates 55 degrees closer to the alpha-helices, which provide most of the protein's interactions with InsP3. These data reveal the molecular determinants of IP6K activity, and suggest an unusual evolutionary trajectory for a primordial kinase that could have favored efficient bifunctionality, before propagation of separate IP3Ks and IP6Ks.
		+
		+	IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.,Wang H, DeRose EF, London RE, Shears SB Nat Commun. 2014 Jun 24;5:4178. doi: 10.1038/ncomms5178. PMID:24956979<ref>PMID:24956979</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:16, 18 June 2014

2014-06-18T08:16:32Z

←Older revision		Revision as of 08:16, 18 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA==
-		+	<StructureSection load='4o4c' size='340' side='right' caption='[[4o4c]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~The entry~~ 4o4c is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4o4c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4C FirstGlance]. <br>
-	~~Authors~~: ~~Wang~~, H., Shears, S.B.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4b\|4o4b]], [[4o4d\|4o4d]], [[4o4e\|4o4e]], [[4o4f\|4o4f]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-hexakisphosphate_kinase Inositol-hexakisphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.21 2.7.4.21] </span></td></tr>
-	~~Description~~: ~~Crystal Structure of an~~ Inositol ~~hexakisphosphate~~ kinase ~~apo-EhIP6KA~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4c RCSB], [http://www.ebi.ac.uk/pdbsum/4o4c PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Inositol-hexakisphosphate kinase]]
		+	[[Category: Shears, S B.]]
		+	[[Category: Wang, H.]]
		+	[[Category: Inositol phosphate]]
		+	[[Category: Pdkg kinase]]
		+	[[Category: Transferase]]

OCA at 07:55, 28 May 2014

2014-05-28T07:55:05Z

←Older revision		Revision as of 07:55, 28 May 2014
Line 5:		Line 5:
	Authors: Wang, H., Shears, S.B.		Authors: Wang, H., Shears, S.B.

-	Description: Crystal Structure of an Inositol kinase	+	Description: Crystal Structure of an Inositol hexakisphosphate kinase apo-EhIP6KA

OCA at 10:23, 5 February 2014

2014-02-05T10:23:46Z

←Older revision		Revision as of 10:23, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4o4c is ON HOLD	+	The entry 4o4c is ON HOLD until Paper Publication

	Authors: Wang, H., Shears, S.B.		Authors: Wang, H., Shears, S.B.

	Description: Crystal Structure of an Inositol kinase		Description: Crystal Structure of an Inositol kinase

OCA at 07:40, 15 January 2014

2014-01-15T07:40:34Z

←Older revision		Revision as of 07:40, 15 January 2014
Line 3:		Line 3:
	The entry 4o4c is ON HOLD		The entry 4o4c is ON HOLD

-	Authors: ~~Huanchen~~ Wang, ~~Stephen B~~. Shears	+	Authors: Wang, H., Shears, S.B.

-	Description: Crystal Structure ~~of an Inositol kinaseCrystal Strucutre~~ of an Inositol kinase	+	Description: Crystal Structure of an Inositol kinase