4o4i - Revision history

OCA at 17:07, 20 September 2023

2023-09-20T17:07:10Z

←Older revision		Revision as of 17:07, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [https://pdbe.org/4o4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [https://www.ebi.ac.uk/pdbsum/4o4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [https://pdbe.org/4o4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [https://www.ebi.ac.uk/pdbsum/4o4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4i ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:55, 18 January 2023

2023-01-18T08:55:39Z

←Older revision		Revision as of 08:55, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4o4i' size='340' side='right'caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4o4i' size='340' side='right'caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4h\|4o4h]], [[4o4j\|4o4j]], [[4o4l\|4o4l]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [https://pdbe.org/4o4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [https://www.ebi.ac.uk/pdbsum/4o4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4i ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [~~http~~://pdbe.org/4o4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4i ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]		*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
-	*[[Tubulin\|Tubulin]]	+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]		*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
-	*[[User:Alisa Cario\|User:Alisa Cario]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Buffalo rat]]~~	+	[[Category: Gallus gallus]]
-	~~[[Category: Chick~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Altmann~~, K H~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Bargsten, K]]	+	[[Category: Altmann KH]]
-	[[Category: Diaz~~, J F~~]]	+	[[Category: Bargsten K]]
-	[[Category: Marsh, M]]	+	[[Category: Diaz JF]]
-	[[Category: Miller~~, J H~~]]	+	[[Category: Marsh M]]
-	[[Category: Northcote~~, P T~~]]	+	[[Category: Miller JH]]
-	[[Category: Prota~~, A E~~]]	+	[[Category: Northcote PT]]
-	[[Category: Steinmetz~~, M O]]~~	+	[[Category: Prota AE]]
-	~~[[Category: Alpha-tubulin]]~~	+	[[Category: Steinmetz MO]]
-	~~[[Category: Beta-tubulin]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell cycle-inhibitor complex]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Epothilone some]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Laulimalide]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Stathmin]]~~	+
-	~~[[Category: Tubulin fold~~]]	+

OCA at 05:14, 13 February 2020

2020-02-13T05:14:28Z

←Older revision		Revision as of 05:14, 13 February 2020
Line 1:		Line 1:

	==Tubulin-Laulimalide-Epothilone A complex==		==Tubulin-Laulimalide-Epothilone A complex==
-	<StructureSection load='4o4i' size='340' side='right' caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4o4i' size='340' side='right'caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4I FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4o4i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4o4i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
		+	*[[Tubulin\|Tubulin]]
		+	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
		+	*[[User:Alisa Cario\|User:Alisa Cario]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 32:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Altmann, K H]]		[[Category: Altmann, K H]]
	[[Category: Bargsten, K]]		[[Category: Bargsten, K]]

OCA at 14:23, 15 November 2017

2017-11-15T14:23:09Z

←Older revision		Revision as of 14:23, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4o4i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4o4i" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Stathmin\|Stathmin]]
-	*[[Tubulin\|Tubulin]]
-	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:16, 5 August 2016

2016-08-05T20:16:45Z

←Older revision		Revision as of 20:16, 5 August 2016
Line 1:		Line 1:
		+
	==Tubulin-Laulimalide-Epothilone A complex==		==Tubulin-Laulimalide-Epothilone A complex==
	<StructureSection load='4o4i' size='340' side='right' caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4o4i' size='340' side='right' caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4h\|4o4h]], [[4o4j\|4o4j]], [[4o4l\|4o4l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4h\|4o4h]], [[4o4j\|4o4j]], [[4o4l\|4o4l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [http://www.ebi.ac.uk/pdbsum/4o4i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [http://pdbe.org/4o4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [http://www.ebi.ac.uk/pdbsum/4o4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o4i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Stathmin\|Stathmin]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
		+	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:32, 25 December 2014

2014-12-25T05:32:14Z

←Older revision		Revision as of 05:32, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4o4i\| PDB~~=4o4i \| ~~SCENE~~= }}	+	==Tubulin-Laulimalide-Epothilone A complex==
-	===~~Tubulin~~-~~Laulimalide~~-~~Epothilone~~ A ~~complex~~===	+	<StructureSection load='4o4i' size='340' side='right' caption='[[4o4i]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24470331}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4o4i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4I FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o4h\|4o4h]], [[4o4j\|4o4j]], [[4o4l\|4o4l]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4i RCSB], [http://www.ebi.ac.uk/pdbsum/4o4i PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).		[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Laulimalide and peloruside A are microtubule-stabilizing agents (MSAs), the mechanism of action on microtubules of which is poorly defined. Here, using X-ray crystallography it is shown that laulimalide and peloruside A bind to a unique non-taxane site on beta-tubulin and use their respective macrolide core structures to interact with a second tubulin dimer across protofilaments. At the same time, they allosterically stabilize the taxane-site M-loop that establishes lateral tubulin contacts in microtubules. Structures of ternary complexes of tubulin with laulimalide/peloruside A and epothilone A are also solved, and a crosstalk between the laulimalide/peloruside and taxane sites via the M-loop of beta-tubulin is found. Together, the data define the mechanism of action of laulimalide and peloruside A on tubulin and microtubules. The data further provide a structural framework for understanding the synergy observed between two classes of MSAs in tubulin assembly and the inhibition of cancer cell growth.
		+
		+	Structural basis of microtubule stabilization by laulimalide and peloruside a.,Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Diaz JF, Steinmetz MO Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749., Epub 2014 Jan 27. PMID:24470331<ref>PMID:24470331</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4o4i]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/ ] and [http://en~~.~~wikipedia.org~~/~~wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024470331</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Tubulin\|Tubulin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Altmann, K H.]]	+	[[Category: Buffalo rat]]
-	[[Category: Bargsten, K.]]	+	[[Category: Chick]]
-	[[Category: Diaz, J F.]]	+	[[Category: Altmann, K H]]
-	[[Category: Marsh, M.]]	+	[[Category: Bargsten, K]]
-	[[Category: Miller, J H.]]	+	[[Category: Diaz, J F]]
-	[[Category: Northcote, P T.]]	+	[[Category: Marsh, M]]
-	[[Category: Prota, A E.]]	+	[[Category: Miller, J H]]
-	[[Category: Steinmetz, M O.]]	+	[[Category: Northcote, P T]]
		+	[[Category: Prota, A E]]
		+	[[Category: Steinmetz, M O]]
	[[Category: Alpha-tubulin]]		[[Category: Alpha-tubulin]]
	[[Category: Beta-tubulin]]		[[Category: Beta-tubulin]]

OCA at 13:50, 12 March 2014

2014-03-12T13:50:53Z

←Older revision		Revision as of 13:50, 12 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4o4i\| PDB=4o4i \| SCENE= }}
		+	===Tubulin-Laulimalide-Epothilone A complex===
		+	{{ABSTRACT_PUBMED_24470331}}

-	~~The entry 4o4i~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

-	~~Authors~~: ~~Prota, A~~.E.~~, Bargsten, K~~.~~, Northcote, P~~.T.~~, Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J~~.F.~~, Steinmetz, M~~.O.	+	==About this Structure==
		+	[[4o4i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4I OCA].

-	~~Description~~: ~~Tubulin~~-~~Laulimalide~~-~~Epothilone A~~ complex	+	==Reference==
		+	<ref group="xtra">PMID:024470331</ref><references group="xtra"/><references/>
		+	[[Category: Bos taurus]]
		+	[[Category: Altmann, K H.]]
		+	[[Category: Bargsten, K.]]
		+	[[Category: Diaz, J F.]]
		+	[[Category: Marsh, M.]]
		+	[[Category: Miller, J H.]]
		+	[[Category: Northcote, P T.]]
		+	[[Category: Prota, A E.]]
		+	[[Category: Steinmetz, M O.]]
		+	[[Category: Alpha-tubulin]]
		+	[[Category: Beta-tubulin]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell cycle-inhibitor complex]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Epothilone some]]
		+	[[Category: Gtpase]]
		+	[[Category: Laulimalide]]
		+	[[Category: Ligase]]
		+	[[Category: Microtubule]]
		+	[[Category: Stathmin]]
		+	[[Category: Tubulin fold]]

OCA: Protected "4o4i" [edit=sysop:move=sysop]

2013-12-25T09:33:47Z

Protected "4o4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 25 December 2013

OCA: New page: '''Unreleased structure''' The entry 4o4i is ON HOLD Authors: Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O. Descriptio...

2013-12-25T09:33:46Z

New page: '''Unreleased structure''' The entry 4o4i is ON HOLD Authors: Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O. Descriptio...

New page

'''Unreleased structure'''

The entry 4o4i is ON HOLD

Authors: Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.

Description: Tubulin-Laulimalide-Epothilone A complex