4oa5 - Revision history

OCA at 12:38, 1 March 2024

2024-03-01T12:38:37Z

←Older revision		Revision as of 12:38, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anaplasma_phagocytophilum_str._HZ Anaplasma phagocytophilum str. HZ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anaplasma_phagocytophilum_str._HZ Anaplasma phagocytophilum str. HZ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [https://pdbe.org/4oa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oa5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [https://pdbe.org/4oa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oa5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q2GKC7_ANAPZ Q2GKC7_ANAPZ]		[https://www.uniprot.org/uniprot/Q2GKC7_ANAPZ Q2GKC7_ANAPZ]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Anaplasma phagocytophilum, the causative agent of Human Granulocytic Anaplasmosis (HGA), is an obligately intracellular alpha-proteobacterium that is transmitted by Ixodes spp ticks. However, the pathogen is not transovarially transmitted between tick generations and therefore needs to survive in both a mammalian host and the arthropod vector to complete its life cycle. To adapt to different environments, pathogens rely on differential gene expression as well as the modification of proteins and other molecules. Random transposon mutagenesis of A. phagocytophilum resulted in an insertion within the coding region of an o-methyltransferase (omt) family 3 gene. In wild-type bacteria, expression of omt was up-regulated during binding to tick cells (ISE6) at 2 hr post-inoculation, but nearly absent by 4 hr p.i. Gene disruption reduced bacterial binding to ISE6 cells, and the mutant bacteria that were able to enter the cells were arrested in their replication and development. Analyses of the proteomes of wild-type versus mutant bacteria during binding to ISE6 cells identified Major Surface Protein 4 (Msp4), but also hypothetical protein APH_0406, as the most differentially methylated. Importantly, two glutamic acid residues (the targets of the OMT) were methyl-modified in wild-type Msp4, whereas a single asparagine (not a target of the OMT) was methylated in APH_0406. In vitro methylation assays demonstrated that recombinant OMT specifically methylated Msp4. Towards a greater understanding of the overall structure and catalytic activity of the OMT, we solved the apo (PDB_ID:4OA8), the S-adenosine homocystein-bound (PDB_ID:4OA5), the SAH-Mn2+ bound (PDB_ID:4PCA), and SAM- Mn2+ bound (PDB_ID:4PCL) X-ray crystal structures of the enzyme. Here, we characterized a mutation in A. phagocytophilum that affected the ability of the bacteria to productively infect cells from its natural vector. Nevertheless, due to the lack of complementation, we cannot rule out secondary mutations.
-
-	An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.,Oliva Chavez AS, Fairman JW, Felsheim RF, Nelson CM, Herron MJ, Higgins L, Burkhardt NY, Oliver JD, Markowski TW, Kurtti TJ, Edwards TE, Munderloh UG PLoS Pathog. 2015 Nov 6;11(11):e1005248. doi: 10.1371/journal.ppat.1005248., eCollection 2015 Nov. PMID:26544981<ref>PMID:26544981</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4oa5" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Anaplasma phagocytophilum str. HZ]]		[[Category: Anaplasma phagocytophilum str. HZ]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:13, 25 January 2023

2023-01-25T07:13:40Z

←Older revision		Revision as of 07:13, 25 January 2023
Line 1:		Line 1:
		+
	==X-ray crystal structure of an O-methyltransferase from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing==		==X-ray crystal structure of an O-methyltransferase from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing==
-	<StructureSection load='4oa5' size='340' side='right' caption='[[4oa5]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4oa5' size='340' side='right'caption='[[4oa5]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anapz Anapz~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anaplasma_phagocytophilum_str._HZ Anaplasma phagocytophilum str. HZ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [https://pdbe.org/4oa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oa5 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [~~http~~://pdbe.org/4oa5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2GKC7_ANAPZ Q2GKC7_ANAPZ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anapz~~]]	+	[[Category: Anaplasma phagocytophilum str. HZ]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Large Structures]]
-	~~[[Category: National institute of allergy and infectious disease]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: O-methyltransferase]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:48, 20 January 2016

2016-01-20T08:48:09Z

←Older revision		Revision as of 08:48, 20 January 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [http://pdbe.org/4oa5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anaplasma phagocytophilum, the causative agent of Human Granulocytic Anaplasmosis (HGA), is an obligately intracellular alpha-proteobacterium that is transmitted by Ixodes spp ticks. However, the pathogen is not transovarially transmitted between tick generations and therefore needs to survive in both a mammalian host and the arthropod vector to complete its life cycle. To adapt to different environments, pathogens rely on differential gene expression as well as the modification of proteins and other molecules. Random transposon mutagenesis of A. phagocytophilum resulted in an insertion within the coding region of an o-methyltransferase (omt) family 3 gene. In wild-type bacteria, expression of omt was up-regulated during binding to tick cells (ISE6) at 2 hr post-inoculation, but nearly absent by 4 hr p.i. Gene disruption reduced bacterial binding to ISE6 cells, and the mutant bacteria that were able to enter the cells were arrested in their replication and development. Analyses of the proteomes of wild-type versus mutant bacteria during binding to ISE6 cells identified Major Surface Protein 4 (Msp4), but also hypothetical protein APH_0406, as the most differentially methylated. Importantly, two glutamic acid residues (the targets of the OMT) were methyl-modified in wild-type Msp4, whereas a single asparagine (not a target of the OMT) was methylated in APH_0406. In vitro methylation assays demonstrated that recombinant OMT specifically methylated Msp4. Towards a greater understanding of the overall structure and catalytic activity of the OMT, we solved the apo (PDB_ID:4OA8), the S-adenosine homocystein-bound (PDB_ID:4OA5), the SAH-Mn2+ bound (PDB_ID:4PCA), and SAM- Mn2+ bound (PDB_ID:4PCL) X-ray crystal structures of the enzyme. Here, we characterized a mutation in A. phagocytophilum that affected the ability of the bacteria to productively infect cells from its natural vector. Nevertheless, due to the lack of complementation, we cannot rule out secondary mutations.
		+
		+	An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.,Oliva Chavez AS, Fairman JW, Felsheim RF, Nelson CM, Herron MJ, Higgins L, Burkhardt NY, Oliver JD, Markowski TW, Kurtti TJ, Edwards TE, Munderloh UG PLoS Pathog. 2015 Nov 6;11(11):e1005248. doi: 10.1371/journal.ppat.1005248., eCollection 2015 Nov. PMID:26544981<ref>PMID:26544981</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4oa5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:11, 5 January 2015

2015-01-05T09:11:34Z

←Older revision		Revision as of 09:11, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anapz Anapz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anapz Anapz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Anapz]]		[[Category: Anapz]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: National institute of allergy and infectious disease]]		[[Category: National institute of allergy and infectious disease]]
	[[Category: Niaid]]		[[Category: Niaid]]
	[[Category: O-methyltransferase]]		[[Category: O-methyltransferase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 12:36, 18 May 2014

2014-05-18T12:36:14Z

←Older revision		Revision as of 12:36, 18 May 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==X-ray crystal structure of an O-methyltransferase from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing==
-		+	<StructureSection load='4oa5' size='340' side='right' caption='[[4oa5]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 4oa5 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4oa5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anapz Anapz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OA5 FirstGlance]. <br>
-	~~Authors~~: Seattle Structural Genomics Center for Infectious Disease ~~(SSGCID)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oa8\|4oa8]]</td></tr>
-	~~Description~~: ~~X-ray crystal structure~~ of an O-methyltransferase ~~from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APH_0584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212042 ANAPZ])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oa5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oa5 PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Anapz]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: National institute of allergy and infectious disease]]
		+	[[Category: Niaid]]
		+	[[Category: O-methyltransferase]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]

OCA: Protected "4oa5" [edit=sysop:move=sysop]

2014-01-15T07:43:35Z

Protected "4oa5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:43, 15 January 2014

OCA: New page: '''Unreleased structure''' The entry 4oa5 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of an O-methyltran...

2014-01-15T07:43:34Z

New page: '''Unreleased structure''' The entry 4oa5 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of an O-methyltran...

New page

'''Unreleased structure'''

The entry 4oa5 is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: X-ray crystal structure of an O-methyltransferase from Anaplasma phagocytophilum bound to SAH solved by iodide SAD phasing