4oku - Revision history

OCA at 07:30, 25 January 2023

2023-01-25T07:30:56Z

←Older revision		Revision as of 07:30, 25 January 2023
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	==Structure of Toxoplasma gondii proMIC2==		==Structure of Toxoplasma gondii proMIC2==
-	<StructureSection load='4oku' size='340' side='right' caption='[[4oku]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4oku' size='340' side='right'caption='[[4oku]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oku]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4okr\|4okr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oku OCA], [https://pdbe.org/4oku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oku RCSB], [https://www.ebi.ac.uk/pdbsum/4oku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oku ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGVEG_201780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oku OCA], [~~http~~://pdbe.org/4oku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oku ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O00816_TOXGO O00816_TOXGO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Toxgo~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Song, G~~]]	+	[[Category: Toxoplasma gondii]]
-	[[Category: ~~Springer, T A~~]]	+	[[Category: Song G]]
-	[[Category: ~~Adhesin]]~~	+	[[Category: Springer TA]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Gliding motility]]~~	+
-	~~[[Category: Integrin i domain]]~~	+
-	~~[[Category: Tsr domain]]~~	+
-	~~[[Category: Vwa~~]]	+

OCA at 17:08, 2 January 2017

2017-01-02T17:08:38Z

←Older revision		Revision as of 17:08, 2 January 2017
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-	{{STRUCTURE_4oku\| PDB=4oku \| SCENE= }}
-	===Structure of Toxoplasma gondii proMIC2===
-	{{ABSTRACT_PUBMED_24639528}}

-	==~~About this~~ Structure==	+	==Structure of Toxoplasma gondii proMIC2==
-	[[4oku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA].	+	<StructureSection load='4oku' size='340' side='right' caption='[[4oku]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4oku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4okr\|4okr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGVEG_201780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oku OCA], [http://pdbe.org/4oku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oku RCSB], [http://www.ebi.ac.uk/pdbsum/4oku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oku ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Micronemal protein 2 (MIC2) is the key adhesin that supports gliding motility and host cell invasion by Toxoplasma gondii. With a von Willebrand factor A (VWA) domain and six thrombospondin repeat domains (TSR1-6) in its ectodomain, MIC2 connects to the parasite actomyosin system through its cytoplasmic tail. MIC2-associated protein (M2AP) binds noncovalently to the MIC2 ectodomain. MIC2 and M2AP are stored in micronemes as proforms. We find that the MIC2-M2AP ectodomain complex is a highly elongated 1:1 monomer with M2AP bound to the TSR6 domain. Crystal structures of N-terminal fragments containing the VWA and TSR1 domains for proMIC2 and MIC2 reveal a closed conformation of the VWA domain and how it associates with the TSR1 domain. A long, proline-rich, disulfide-bonded pigtail loop in TSR1 overlaps the VWA domain. Mannose alpha-C-linked to Trp-276 in TSR1 has an unusual (1)C4 chair conformation. The MIC2 VWA domain includes a mobile alpha5-helix and a 22-residue disordered region containing two disulfide bonds in place of an alpha6-helix. A hydrophobic residue in the prodomain binds to a pocket adjacent to the alpha7-helix that pistons in opening of the VWA domain to a putative high-affinity state.

-	~~==Reference==~~	+	Structures of the Toxoplasma gliding motility adhesin.,Song G, Springer TA Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4862-7. doi:, 10.1073/pnas.1403059111. Epub 2014 Mar 17. PMID:24639528<ref>PMID:24639528</ref>
-	<ref ~~group="xtra"~~>PMID:~~024639528~~</ref><~~references group~~="~~xtra~~"/><references/>	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4oku" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Toxgo]]		[[Category: Toxgo]]
-	[[Category: Song, G.]]	+	[[Category: Song, G]]
-	[[Category: Springer, T A.]]	+	[[Category: Springer, T A]]
	[[Category: Adhesin]]		[[Category: Adhesin]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 06:51, 23 April 2014

2014-04-23T06:51:34Z

←Older revision		Revision as of 06:51, 23 April 2014
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	{{STRUCTURE_4oku\| PDB=4oku \| SCENE= }}		{{STRUCTURE_4oku\| PDB=4oku \| SCENE= }}
	===Structure of Toxoplasma gondii proMIC2===		===Structure of Toxoplasma gondii proMIC2===
		+	{{ABSTRACT_PUBMED_24639528}}

	==About this Structure==		==About this Structure==
-	[[4oku]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA].	+	[[4oku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024639528</ref><references group="xtra"/><references/>
		+	[[Category: Toxgo]]
	[[Category: Song, G.]]		[[Category: Song, G.]]
	[[Category: Springer, T A.]]		[[Category: Springer, T A.]]

OCA at 09:43, 19 March 2014

2014-03-19T09:43:33Z

←Older revision		Revision as of 09:43, 19 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4oku\| PDB=4oku \| SCENE= }}
		+	===Structure of Toxoplasma gondii proMIC2===

-	~~The entry~~ 4oku is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4oku]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKU OCA].
-	~~Authors~~: Song, G., Springer, T.A.	+	[[Category: Song, G.]]
-		+	[[Category: Springer, T A.]]
-	~~Description~~: ~~Structure of Toxoplasma gondii proMIC2~~	+	[[Category: Adhesin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Gliding motility]]
		+	[[Category: Integrin i domain]]
		+	[[Category: Tsr domain]]
		+	[[Category: Vwa]]

OCA at 12:16, 12 March 2014

2014-03-12T12:16:27Z

←Older revision		Revision as of 12:16, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oku is ON HOLD	+	The entry 4oku is ON HOLD until Paper Publication

	Authors: Song, G., Springer, T.A.		Authors: Song, G., Springer, T.A.

	Description: Structure of Toxoplasma gondii proMIC2		Description: Structure of Toxoplasma gondii proMIC2

OCA at 10:31, 5 February 2014

2014-02-05T10:31:09Z

←Older revision		Revision as of 10:31, 5 February 2014
Line 3:		Line 3:
	The entry 4oku is ON HOLD		The entry 4oku is ON HOLD

-	Authors: Song, G. , Springer, T.A.	+	Authors: Song, G., Springer, T.A.

	Description: Structure of Toxoplasma gondii proMIC2		Description: Structure of Toxoplasma gondii proMIC2

OCA: Protected "4oku" [edit=sysop:move=sysop]

2014-01-29T07:12:27Z

Protected "4oku" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 29 January 2014

OCA: New page: '''Unreleased structure''' The entry 4oku is ON HOLD Authors: Song, G. , Springer, T.A. Description: Structure of Toxoplasma gondii proMIC2

2014-01-29T07:12:26Z

New page: '''Unreleased structure''' The entry 4oku is ON HOLD Authors: Song, G. , Springer, T.A. Description: Structure of Toxoplasma gondii proMIC2

New page

'''Unreleased structure'''

The entry 4oku is ON HOLD

Authors: Song, G. , Springer, T.A.

Description: Structure of Toxoplasma gondii proMIC2