4okz - Revision history

OCA at 17:15, 20 September 2023

2023-09-20T17:15:59Z

←Older revision		Revision as of 17:15, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_pristinaespiralis_ATCC_25486 Streptomyces pristinaespiralis ATCC 25486]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_pristinaespiralis_ATCC_25486 Streptomyces pristinaespiralis ATCC 25486]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [https://pdbe.org/4okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [https://www.ebi.ac.uk/pdbsum/4okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [https://pdbe.org/4okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [https://www.ebi.ac.uk/pdbsum/4okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:31, 25 January 2023

2023-01-25T07:31:08Z

←Older revision		Revision as of 07:31, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='4okz' size='340' side='right'caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4okz' size='340' side='right'caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Stre2 Stre2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_pristinaespiralis_ATCC_25486 Streptomyces pristinaespiralis ATCC 25486]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [https://pdbe.org/4okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [https://www.ebi.ac.uk/pdbsum/4okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSDG_02809, ZP_06911744 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=457429 STRE2])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [~~http~~://pdbe.org/4okz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4okz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SEDS_STRE2 SEDS_STRE2] Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene selina-4(15),7(11)-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP leading to a (E,E)-germacradienyl cation (PubMed:23307484, PubMed:24890698). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:23307484, PubMed:24890698).<ref>PMID:23307484</ref> <ref>PMID:24890698</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Squalene synthase]]~~	+	[[Category: Streptomyces pristinaespiralis ATCC 25486]]
-	~~[[Category: Stre2~~]]	+	[[Category: Baer P]]
-	[[Category: Baer, P]]	+	[[Category: Citron CA]]
-	[[Category: Citron~~, C A~~]]	+	[[Category: Dickschat JS]]
-	[[Category: Dickschat~~, J S~~]]	+	[[Category: Fischer K]]
-	[[Category: Fischer, K]]	+	[[Category: Groll M]]
-	[[Category: Groll, M]]	+	[[Category: Klapschinski T]]
-	[[Category: Klapschinski, T]]	+	[[Category: Rabe P]]
-	[[Category: Rabe, P]]	+
-	~~[[Category: Closed conformation]]~~	+
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Dihydrofarnesyl pyrophosphate]]~~	+
-	~~[[Category: Induced fit]]~~	+
-	~~[[Category: Pyrophosphate sensor]]~~	+
-	~~[[Category: Sesquiterpene]]~~	+
-	~~[[Category: Terpenoid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:23, 17 April 2019

2019-04-17T07:23:14Z

←Older revision		Revision as of 07:23, 17 April 2019
Line 1:		Line 1:

	==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==		==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==
-	<StructureSection load='4okz' size='340' side='right' caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4okz' size='340' side='right'caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Stre2 Stre2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSDG_02809, ZP_06911744 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=457429 STRE2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://pdbe.org/4okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://pdbe.org/4okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
		+	[[Category: Stre2]]
	[[Category: Baer, P]]		[[Category: Baer, P]]
	[[Category: Citron, C A]]		[[Category: Citron, C A]]

OCA at 19:38, 11 August 2016

2016-08-11T19:38:01Z

←Older revision		Revision as of 19:38, 11 August 2016
Line 1:		Line 1:
		+
	==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==		==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==
	<StructureSection load='4okz' size='340' side='right' caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4okz' size='340' side='right' caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://pdbe.org/4okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4okz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:15, 5 January 2015

2015-01-05T14:15:03Z

←Older revision		Revision as of 14:15, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Squalene synthase]]		[[Category: Squalene synthase]]
-	[[Category: Baer, P.]]	+	[[Category: Baer, P]]
-	[[Category: Citron, C A.]]	+	[[Category: Citron, C A]]
-	[[Category: Dickschat, J S.]]	+	[[Category: Dickschat, J S]]
-	[[Category: Fischer, K.]]	+	[[Category: Fischer, K]]
-	[[Category: Groll, M.]]	+	[[Category: Groll, M]]
-	[[Category: Klapschinski, T.]]	+	[[Category: Klapschinski, T]]
-	[[Category: Rabe, P.]]	+	[[Category: Rabe, P]]
	[[Category: Closed conformation]]		[[Category: Closed conformation]]
	[[Category: Cyclase]]		[[Category: Cyclase]]

OCA at 13:35, 20 August 2014

2014-08-20T13:35:58Z

←Older revision		Revision as of 13:35, 20 August 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~FPP~~:~~FARNESYL~~+DIPHOSPHATE'>~~FPP~~</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3E9:(3S,6E)-3,7,11-TRIMETHYLDODECA-6,10-DIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>3E9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>

OCA at 06:22, 2 July 2014

2014-07-02T06:22:22Z

←Older revision		Revision as of 06:22, 2 July 2014
Line 8:		Line 8:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present crystallographic and functional data of selina-4(15),7(11)-diene synthase (SdS) from Streptomyces pristinaespiralis in its open and closed (ligand-bound) conformation. We could identify an induced-fit mechanism by elucidating a rearrangement of the G1/2 helix-break motif upon substrate binding. This rearrangement highlights a novel effector triad comprising the pyrophosphate sensor Arg178, the linker Asp181, and the effector Gly182-O. This structural motif is strictly conserved in class I terpene cyclases from bacteria, fungi, and plants, including epi-isozizaene synthase (3KB9), aristolochene synthase (4KUX), bornyl diphosphate synthase (1N20), limonene synthase (2ONG), 5-epi-aristolochene synthase (5EAT), and taxa-4(5),11(12)-diene synthase (3P5R). An elaborate structure-based mutagenesis in combination with analysis of the distinct product spectra confirmed the mechanistic models of carbocation formation and stabilization in SdS.
		+
		+	Induced-Fit Mechanism in Class I Terpene Cyclases.,Baer P, Rabe P, Fischer K, Citron CA, Klapschinski TA, Groll M, Dickschat JS Angew Chem Int Ed Engl. 2014 May 30. doi: 10.1002/anie.201403648. PMID:24890698<ref>PMID:24890698</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:55, 11 June 2014

2014-06-11T08:55:47Z

←Older revision		Revision as of 08:55, 11 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate==
-		+	<StructureSection load='4okz' size='340' side='right' caption='[[4okz]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~The entry~~ 4okz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4okz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKZ FirstGlance]. <br>
-	~~Authors~~: ~~Baer~~, P., ~~Rabe~~, P., ~~Fischer~~, K., Citron, C.A., ~~Klapschinski, T~~., Groll, M., ~~Dickschat~~, ~~J.S~~.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ps1\|1ps1]], [[4mc0\|4mc0]], [[4mc3\|4mc3]], [[4okm\|4okm]]</td></tr>
-	~~Description~~: ~~Selinadiene Synthase in complex with dihydrofarnesyl~~ pyrophosphate	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okz RCSB], [http://www.ebi.ac.uk/pdbsum/4okz PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Squalene synthase]]
		+	[[Category: Baer, P.]]
		+	[[Category: Citron, C A.]]
		+	[[Category: Dickschat, J S.]]
		+	[[Category: Fischer, K.]]
		+	[[Category: Groll, M.]]
		+	[[Category: Klapschinski, T.]]
		+	[[Category: Rabe, P.]]
		+	[[Category: Closed conformation]]
		+	[[Category: Cyclase]]
		+	[[Category: Dihydrofarnesyl pyrophosphate]]
		+	[[Category: Induced fit]]
		+	[[Category: Pyrophosphate sensor]]
		+	[[Category: Sesquiterpene]]
		+	[[Category: Terpenoid]]
		+	[[Category: Transferase]]

OCA at 04:51, 13 February 2014

2014-02-13T04:51:05Z

←Older revision		Revision as of 04:51, 13 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4okz is ON HOLD	+	The entry 4okz is ON HOLD until Paper Publication

	Authors: Baer, P., Rabe, P., Fischer, K., Citron, C.A., Klapschinski, T., Groll, M., Dickschat, J.S.		Authors: Baer, P., Rabe, P., Fischer, K., Citron, C.A., Klapschinski, T., Groll, M., Dickschat, J.S.

	Description: Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate		Description: Selinadiene Synthase in complex with dihydrofarnesyl pyrophosphate

OCA: Protected "4okz" [edit=sysop:move=sysop]

2014-01-29T07:12:36Z

Protected "4okz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 29 January 2014