4oqt - Revision history

OCA at 07:40, 25 January 2023

2023-01-25T07:40:42Z

←Older revision		Revision as of 07:40, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='4oqt' size='340' side='right'caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>		<StructureSection load='4oqt' size='340' side='right'caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LINGO1, LERN1, LRRN6A, UNQ201/PRO227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [https://pdbe.org/4oqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [https://www.ebi.ac.uk/pdbsum/4oqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqt ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [~~http~~://pdbe.org/4oqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Hereditary essential tremor.	+	[https://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN] Hereditary essential tremor.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:14966521</ref> <ref>PMID:15895088</ref> <ref>PMID:15694321</ref> <ref>PMID:17005555</ref>	+	[https://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN] Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:14966521</ref> <ref>PMID:15895088</ref> <ref>PMID:15694321</ref> <ref>PMID:17005555</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arndt~~, J W~~]]	+	[[Category: Arndt JW]]
-	[[Category: Gao, Y]]	+	[[Category: Gao Y]]
-	[[Category: Lee, X]]	+	[[Category: Lee X]]
-	[[Category: Mi, S]]	+	[[Category: Mi S]]
-	[[Category: Pepinsky~~, R B~~]]	+	[[Category: Pepinsky RB]]
-	[[Category: Quan, C]]	+	[[Category: Quan C]]
-	[[Category: Quintero-Monzon, O]]	+	[[Category: Quintero-Monzon O]]
-	~~[[Category: Ig domain]]~~	+
-	~~[[Category: Leucine rich repeat]]~~	+
-	~~[[Category: Membrane protein-immune system complex~~]]	+

OCA at 07:54, 17 April 2019

2019-04-17T07:54:42Z

←Older revision		Revision as of 07:54, 17 April 2019
Line 1:		Line 1:

	==LINGO-1/Li81 Fab complex==		==LINGO-1/Li81 Fab complex==
-	<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>	+	<StructureSection load='4oqt' size='340' side='right'caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LINGO1, LERN1, LRRN6A, UNQ201/PRO227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://pdbe.org/4oqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://pdbe.org/4oqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqt ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arndt, J W]]		[[Category: Arndt, J W]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]

OCA at 19:11, 11 August 2016

2016-08-11T19:11:56Z

←Older revision		Revision as of 19:11, 11 August 2016
Line 1:		Line 1:
		+
	==LINGO-1/Li81 Fab complex==		==LINGO-1/Li81 Fab complex==
	<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>		<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://pdbe.org/4oqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4oqt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:38, 5 January 2015

2015-01-05T09:38:00Z

←Older revision		Revision as of 09:38, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Hereditary essential tremor.		[[http://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Hereditary essential tremor.
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arndt, J W.]]	+	[[Category: Arndt, J W]]
-	[[Category: Gao, Y.]]	+	[[Category: Gao, Y]]
-	[[Category: Lee, X.]]	+	[[Category: Lee, X]]
-	[[Category: Mi, S.]]	+	[[Category: Mi, S]]
-	[[Category: Pepinsky, R B.]]	+	[[Category: Pepinsky, R B]]
-	[[Category: Quan, C.]]	+	[[Category: Quan, C]]
-	[[Category: Quintero-Monzon, O.]]	+	[[Category: Quintero-Monzon, O]]
	[[Category: Ig domain]]		[[Category: Ig domain]]
	[[Category: Leucine rich repeat]]		[[Category: Leucine rich repeat]]
	[[Category: Membrane protein-immune system complex]]		[[Category: Membrane protein-immune system complex]]

OCA at 05:30, 18 June 2014

2014-06-18T05:30:47Z

←Older revision		Revision as of 05:30, 18 June 2014
Line 2:		Line 2:
	<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>		<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. <br>	+	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>
	<table>		<table>
Line 17:		Line 16:
	Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.,Pepinsky RB, Arndt JW, Quan C, Gao Y, Quintero-Monzon O, Lee X, Mi S J Pharmacol Exp Ther. 2014 Apr 22. PMID:24756303<ref>PMID:24756303</ref>		Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.,Pepinsky RB, Arndt JW, Quan C, Gao Y, Quintero-Monzon O, Lee X, Mi S J Pharmacol Exp Ther. 2014 Apr 22. PMID:24756303<ref>PMID:24756303</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 07:18, 14 May 2014

2014-05-14T07:18:37Z

←Older revision		Revision as of 07:18, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==LINGO-1/Li81 Fab complex==
		+	<StructureSection load='4oqt' size='340' side='right' caption='[[4oqt]], [[Resolution\|resolution]] 3.23Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4oqt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQT OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oqt RCSB], [http://www.ebi.ac.uk/pdbsum/4oqt PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Hereditary essential tremor.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIGO1_HUMAN LIGO1_HUMAN]] Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:14966521</ref> <ref>PMID:15895088</ref> <ref>PMID:15694321</ref> <ref>PMID:17005555</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multiple sclerosis (MS) is an autoimmune-inflammatory induced disease of the central nervous system (CNS) with prominent demyelination and axonal injury. While most MS therapies target the immunological response, there is a large unmet need for treatments that can promote CNS repair. LINGO-1 (leucine-rich repeat and Ig containing Nogo receptor interacting protein-1) is a membrane protein selectively expressed in the CNS that suppresses myelination, preventing the repair of damaged axons. We are investigating LINGO-1 antagonist antibodies that lead to remyelination as a new paradigm for treatment of individuals with MS. The anti-LINGO-1 Li81 antibody (BIIB033) is currently in clinical trials and is the first MS treatment targeting CNS repair. Here, to elucidate the mechanism of action of the antibody, we solved the crystal structure of the LINGO-1/Li81 Fab complex and used biochemical and functional studies to investigate structure-function relationships. Li81 binds to the convex surface of the leucine-rich repeat domain of LINGO-1 within repeats 4-8. Fab binding blocks contact points used in the oligomerization of LINGO-1 and produces a stable complex containing 2 copies each of LINGO-1 and Fab that results from a rearrangement of contacts stabilizing the quaternary structure of LINGO-1. The formation of the LINGO-1/Li81 Fab complex masks functional epitopes within the Ig domain of LINGO-1 that are important for its biological activity in oligodendrocyte differentiation. These studies provide new insights into the structure and biology of LINGO-1 and how Li81 mAb can block its function.

-	~~The entry 4oqt is ON HOLD until Paper Publication~~	+	Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.,Pepinsky RB, Arndt JW, Quan C, Gao Y, Quintero-Monzon O, Lee X, Mi S J Pharmacol Exp Ther. 2014 Apr 22. PMID:24756303<ref>PMID:24756303</ref>

-	~~Authors: Pepinsky~~, R.B., Arndt, J.W., ~~Quan~~, C., ~~Gao~~, Y., Quintero-Monzon, O.~~, Lee, X., Mi, S.~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~LINGO~~-~~1/Li81 Fab~~ complex	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arndt, J W.]]
		+	[[Category: Gao, Y.]]
		+	[[Category: Lee, X.]]
		+	[[Category: Mi, S.]]
		+	[[Category: Pepinsky, R B.]]
		+	[[Category: Quan, C.]]
		+	[[Category: Quintero-Monzon, O.]]
		+	[[Category: Ig domain]]
		+	[[Category: Leucine rich repeat]]
		+	[[Category: Membrane protein-immune system complex]]

OCA at 08:26, 2 April 2014

2014-04-02T08:26:26Z

←Older revision		Revision as of 08:26, 2 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oqt is ON HOLD	+	The entry 4oqt is ON HOLD until Paper Publication

	Authors: Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S.		Authors: Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S.

	Description: LINGO-1/Li81 Fab complex		Description: LINGO-1/Li81 Fab complex

OCA at 16:49, 3 March 2014

2014-03-03T16:49:16Z

←Older revision		Revision as of 16:49, 3 March 2014
Line 3:		Line 3:
	The entry 4oqt is ON HOLD		The entry 4oqt is ON HOLD

-	Authors: ~~PEPINSKY~~, R.B., ~~ARNDT~~, J.W., ~~QUAN~~, C., ~~GAO~~, Y., Quintero-Monzon, O., ~~LEE~~, X., MI, S.	+	Authors: Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S.

	Description: LINGO-1/Li81 Fab complex		Description: LINGO-1/Li81 Fab complex

OCA: Protected "4oqt" [edit=sysop:move=sysop]

2014-02-19T16:19:54Z

Protected "4oqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:19, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4oqt is ON HOLD Authors: PEPINSKY, R.B., ARNDT, J.W., QUAN, C., GAO, Y., Quintero-Monzon, O., LEE, X., MI, S. Description: LINGO-1/Li81 Fab complex

2014-02-19T16:19:53Z

New page: '''Unreleased structure''' The entry 4oqt is ON HOLD Authors: PEPINSKY, R.B., ARNDT, J.W., QUAN, C., GAO, Y., Quintero-Monzon, O., LEE, X., MI, S. Description: LINGO-1/Li81 Fab complex

New page

'''Unreleased structure'''

The entry 4oqt is ON HOLD

Authors: PEPINSKY, R.B., ARNDT, J.W., QUAN, C., GAO, Y., Quintero-Monzon, O., LEE, X., MI, S.

Description: LINGO-1/Li81 Fab complex