4ovo - Revision history

OCA at 07:26, 17 April 2019

2019-04-17T07:26:56Z

←Older revision		Revision as of 07:26, 17 April 2019
Line 1:		Line 1:
		+
	==REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))==		==REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))==
-	<StructureSection load='4ovo' size='340' side='right' caption='[[4ovo]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4ovo' size='340' side='right'caption='[[4ovo]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gennaeus_nycthemerus Gennaeus nycthemerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gennaeus_nycthemerus Gennaeus nycthemerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://pdbe.org/4ovo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://pdbe.org/4ovo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ovo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/4ovo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/4ovo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Gennaeus nycthemerus]]		[[Category: Gennaeus nycthemerus]]
		+	[[Category: Large Structures]]
	[[Category: Bode, W]]		[[Category: Bode, W]]
	[[Category: Musil, D]]		[[Category: Musil, D]]

OCA at 12:25, 7 February 2016

2016-02-07T12:25:59Z

←Older revision		Revision as of 12:25, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='4ovo' size='340' side='right' caption='[[4ovo]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4ovo' size='340' side='right' caption='[[4ovo]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lophura_nycthemera Lophura nycthemera~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gennaeus_nycthemerus Gennaeus nycthemerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://pdbe.org/4ovo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4ovo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ovo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lophura nycthemera~~]]	+	[[Category: Gennaeus nycthemerus]]
	[[Category: Bode, W]]		[[Category: Bode, W]]
	[[Category: Musil, D]]		[[Category: Musil, D]]

OCA at 09:16, 5 January 2015

2015-01-05T09:16:15Z

←Older revision		Revision as of 09:16, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Lophura nycthemera]]		[[Category: Lophura nycthemera]]
-	[[Category: Bode, W.]]	+	[[Category: Bode, W]]
-	[[Category: Musil, D.]]	+	[[Category: Musil, D]]

OCA: Protected "4ovo" [edit=sysop:move=sysop]

2014-06-05T07:31:44Z

Protected "4ovo" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:31, 5 June 2014

OCA at 07:31, 5 June 2014

2014-06-05T07:31:43Z

←Older revision		Revision as of 07:31, 5 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))==
-	[[~~Image~~:4ovo.~~png\|left~~\|200px]]	+	<StructureSection load='4ovo' size='340' side='right' caption='[[4ovo]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ovo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/4ovo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tetragonal and triclinic crystals of two ovomucoid inhibitor third domains from silver pheasant and Japanese quail, modified at their reactive site bonds Met18-Glu19 (OMSVP3) and Lys18-Asp19 (OMJPQ3), respectively, were obtained. Their molecular and crystal structures were solved using X-ray data to 2.5 A and 1.55 A by means of Patterson search methods using truncated models of the intact (virgin) inhibitors as search models. Both structures were crystallographically refined to R-values of 0.185 and 0.192, respectively, applying an energy restraint reciprocal space refinement procedure. Both modified inhibitors show large deviations from the intact derivatives only in the proteinase binding loops (Pro14 to Arg21) and in the amino-terminal segments (Leu1 to Val6). In the modified inhibitors the residues immediately adjacent to the cleavage site (in particular P2, P1, P1') are mobile and able to adapt to varying crystal environments. The charged end-groups, i.e. Met18 COO- and Glu19 NH3+ in OMSVP3, and Lys18 COO- and Asp19 NH3+ in OMJPQ3, do not form ion pairs with one another. The hydrogen bond connecting the side-chains of Thr17 and Glu19 (i.e. residues on either side of the scissile peptide bond) in OMSVP3 is broken in the modified form, and the hydrogen-bond interactions observed in the intact molecules between the Asn33 side-chain and the carbonyl groups of loop residues P2 and P1' are absent or weak in the modified inhibitors. The reactive site cleavage, however, has little effect on specific interactions within the protein scaffold such as the side-chain hydrogen bond between Asp27 and Tyr31 or the side-chain stacking of Tyr20 and Pro22. The conformational differences in the amino-terminal segment Leu1 to Val6 are explained by their ability to move freely, either to associate with segments of symmetry-related molecules under formation of a four-stranded beta-barrel (OMSVP3* and OMJPQ3) or to bind to surrounding molecules. Together with the results given in the accompanying paper, these findings probably explain why Khyd of small protein inhibitors of serine proteinases is generally found to be so small.

-	<!--	+	Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3) and from Japanese quail (OMJPQ3).,Musil D, Bode W, Huber R, Laskowski M Jr, Lin TY, Ardelt W J Mol Biol. 1991 Aug 5;220(3):739-55. PMID:1870129<ref>PMID:1870129</ref>
-	~~The line below this paragraph, containing "STRUCTURE_4ovo", creates the "Structure Box" on the page.~~	+
-	~~You may change~~ the ~~PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter~~ (~~which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_4ovo\| PDB=4ovo \| SCENE= }}~~	+

-	~~===REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_1870129}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 1870129 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_1870129}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~4OVO is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:1870129<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Lophura nycthemera]]		[[Category: Lophura nycthemera]]
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
	[[Category: Musil, D.]]		[[Category: Musil, D.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:47:51 2009''

OCA at 11:47, 16 February 2009

2009-02-16T11:47:53Z

←Older revision		Revision as of 11:47, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	4OVO is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA].	+	4OVO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA].

	==Reference==		==Reference==
-	Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3) and from Japanese quail (OMJPQ3)., Musil D, Bode W, Huber R, Laskowski M Jr, Lin TY, Ardelt W, J Mol Biol. 1991 Aug 5;220(3):739-55. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/1870129 1870129]~~	+	<ref group="xtra">PMID:1870129</ref><references group="xtra"/>
	[[Category: Lophura nycthemera]]		[[Category: Lophura nycthemera]]
-	[[Category: Single protein]]
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
	[[Category: Musil, D.]]		[[Category: Musil, D.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3~~ 13:45:~~44 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:47:51 2009''

OCA at 10:45, 3 July 2008

2008-07-03T10:45:45Z

←Older revision		Revision as of 10:45, 3 July 2008
Line 1:		Line 1:
-	[[Image:4ovo.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:4ovo.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_4ovo\| PDB=4ovo \| SCENE= }}		{{STRUCTURE_4ovo\| PDB=4ovo \| SCENE= }}

-	~~'''~~REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))~~'''~~	+	===REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))===


-	~~==Overview==~~	+	<!--
-	~~Tetragonal and triclinic crystals of two ovomucoid inhibitor third domains from silver pheasant and Japanese quail, modified at their reactive site bonds Met18~~-~~Glu19 (OMSVP3) and Lys18~~-~~Asp19 (OMJPQ3)~~, ~~respectively~~, ~~were obtained. Their molecular and crystal structures were solved using X-ray data~~ to ~~2.5 A and 1.55 A by means of Patterson search methods using truncated models of~~ the ~~intact~~ (~~virgin) inhibitors~~ as ~~search models~~. ~~Both structures were crystallographically refined to R-values of 0~~.185 and 0.192, respectively, applying an energy restraint reciprocal space refinement procedure. Both modified inhibitors show large deviations from the intact derivatives only in the proteinase binding loops (Pro14 to Arg21) ~~and in the amino-terminal segments (Leu1 to Val6). In the modified inhibitors the residues immediately adjacent to the cleavage site (in particular P2~~, P1, P1') are mobile and able to adapt to varying crystal environments. The charged end-groups, i.e. Met18 COO- and Glu19 NH3+ in OMSVP3, and Lys18 COO- and Asp19 NH3+ in OMJPQ3, do not form ion pairs with one another. The hydrogen bond connecting the side-chains of Thr17 and Glu19 (i.e. residues on either side of the scissile peptide bond) in OMSVP3 is ~~broken in~~ the modified form, and the hydrogen-bond interactions observed in the intact molecules between the Asn33 side-chain and the carbonyl groups of loop residues P2 and P1' are absent or weak in the modified inhibitors. ~~The reactive site cleavage, however, has little effect on specific interactions within the protein scaffold such as the side~~-~~chain hydrogen bond between Asp27 and Tyr31 or the side~~-chain stacking of Tyr20 and Pro22. The conformational differences in the amino-terminal segment Leu1 to Val6 are explained by their ability to move freely, either to associate with segments of symmetry-related molecules under formation of a four-stranded beta-barrel (OMSVP3* and OMJPQ3) or to bind to surrounding molecules. Together with the results given in the accompanying paper, these findings probably explain why Khyd of small protein inhibitors of serine proteinases is generally found to be so small.	+	The line below this paragraph, {{ABSTRACT_PUBMED_1870129}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 1870129 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_1870129}}

	==About this Structure==		==About this Structure==
Line 24:		Line 28:
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
	[[Category: Musil, D.]]		[[Category: Musil, D.]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:27:36 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:45:44 2008''

OCA at 19:27, 4 May 2008

2008-05-04T19:27:37Z

←Older revision		Revision as of 19:27, 4 May 2008
Line 1:		Line 1:
	[[Image:4ovo.gif\|left\|200px]]		[[Image:4ovo.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 4ovo \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>4ovo</scene>~~, ~~resolution 2~~.~~50Å~~	+	The line below this paragraph, containing "STRUCTURE_4ovo", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	\|~~LIGAND~~=	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE=~~	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_4ovo\| PDB=4ovo \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB]</span>	+
-	}}	+

	'''REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))'''		'''REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))'''
Line 27:		Line 24:
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
	[[Category: Musil, D.]]		[[Category: Musil, D.]]
-	~~[[Category: proteinase inhibitor (kazal)]]~~	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:27:36 2008''
-		+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:39:37 2008''	+

OCA at 02:39, 31 March 2008

2008-03-31T02:39:38Z

←Older revision		Revision as of 02:39, 31 March 2008
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	\|ACTIVITY=		\|ACTIVITY=
	\|GENE=		\|GENE=
		+	\|DOMAIN=
		+	\|RELATEDENTRY=
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovo OCA], [http://www.ebi.ac.uk/pdbsum/4ovo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4ovo RCSB]</span>
	}}		}}

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	[[Category: proteinase inhibitor (kazal)]]		[[Category: proteinase inhibitor (kazal)]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 19~~:10:30 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:37 2008''

OCA at 17:10, 20 March 2008

2008-03-20T17:10:31Z

←Older revision		Revision as of 17:10, 20 March 2008
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-	[[Image:4ovo.gif\|left\|200px]]~~<br /><applet load~~="4ovo~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~	+	[[Image:4ovo.gif\|left\|200px]]
-	~~caption="~~4ovo, resolution 2.50Å~~" />~~	+
-	'''REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))'''~~<br />~~	+	{{Structure
		+	\|PDB= 4ovo \|SIZE=350\|CAPTION= <scene name='initialview01'>4ovo</scene>, resolution 2.50Å
		+	\|SITE=
		+	\|LIGAND=
		+	\|ACTIVITY=
		+	\|GENE=
		+	}}
		+
		+	'''REFINED X-RAY CRYSTAL STRUCTURES OF THE REACTIVE SITE MODIFIED OVOMUCOID INHIBITOR THIRD DOMAINS FROM SILVER PHEASANT (OMSVP3(ASTERISK)) AND FROM JAPANESE QUAIL (OMJPQ3(ASTERISK))'''
		+

	==Overview==		==Overview==
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	==About this Structure==		==About this Structure==
-	4OVO is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA].	+	4OVO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVO OCA].

	==Reference==		==Reference==
-	Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3) and from Japanese quail (OMJPQ3)., Musil D, Bode W, Huber R, Laskowski M Jr, Lin TY, Ardelt W, J Mol Biol. 1991 Aug 5;220(3):739-55. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~1870129 1870129]	+	Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3) and from Japanese quail (OMJPQ3)., Musil D, Bode W, Huber R, Laskowski M Jr, Lin TY, Ardelt W, J Mol Biol. 1991 Aug 5;220(3):739-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1870129 1870129]
	[[Category: Lophura nycthemera]]		[[Category: Lophura nycthemera]]
	[[Category: Single protein]]		[[Category: Single protein]]
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	[[Category: proteinase inhibitor (kazal)]]		[[Category: proteinase inhibitor (kazal)]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21~~ 19:13:57 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:10:30 2008''