4oyi - Revision history

OCA at 00:37, 28 December 2023

2023-12-28T00:37:57Z

←Older revision		Revision as of 00:37, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [https://pdbe.org/4oyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [https://www.ebi.ac.uk/pdbsum/4oyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [https://pdbe.org/4oyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [https://www.ebi.ac.uk/pdbsum/4oyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyi ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:32, 1 February 2023

2023-02-01T12:32:23Z

←Older revision		Revision as of 12:32, 1 February 2023
Line 1:		Line 1:

	==Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone==		==Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone==
-	<StructureSection load='4oyi' size='340' side='right' caption='[[4oyi]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4oyi' size='340' side='right'caption='[[4oyi]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OYI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [https://pdbe.org/4oyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [https://www.ebi.ac.uk/pdbsum/4oyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyi ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]]~~, ~~[[4oyb\|4oyb]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyx\|4oyx]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [~~http~~://pdbe.org/4oyi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oyi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>	+	[https://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 22:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase\|Adenylyl cyclase]]	+	*[[3D Adenylyl cyclase 3D structures\|3D Adenylyl cyclase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenylate cyclase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Vinkovic, M]]	+	[[Category: Vinkovic M]]
-	~~[[Category: Lyase~~]]	+

OCA at 09:07, 11 August 2016

2016-08-11T09:07:21Z

←Older revision		Revision as of 09:07, 11 August 2016
Line 1:		Line 1:
		+
	==Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone==		==Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone==
	<StructureSection load='4oyi' size='340' side='right' caption='[[4oyi]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4oyi' size='340' side='right' caption='[[4oyi]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [http://www.ebi.ac.uk/pdbsum/4oyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [http://pdbe.org/4oyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [http://www.ebi.ac.uk/pdbsum/4oyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyi ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4oyi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adenylyl cyclase\|Adenylyl cyclase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:07, 20 January 2015

2015-01-20T10:07:10Z

←Older revision		Revision as of 10:07, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyx\|4oyx]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyx\|4oyx]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [http://www.ebi.ac.uk/pdbsum/4oyi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [http://www.ebi.ac.uk/pdbsum/4oyi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
Line 28:		Line 28:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Vinkovic, M.]]	+	[[Category: Vinkovic, M]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 06:46, 11 June 2014

2014-06-11T06:46:47Z

←Older revision		Revision as of 06:46, 11 June 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4oyi\| PDB=4oyi \| SCENE= }}~~	+	==Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone==
-	===Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone===	+	<StructureSection load='4oyi' size='340' side='right' caption='[[4oyi]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24616449}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4oyi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYI FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VK:(4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE'>1VK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyx\|4oyx]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyi RCSB], [http://www.ebi.ac.uk/pdbsum/4oyi PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. Here, we report the first crystal structure of the human enzyme that reveals a pseudosymmetrical arrangement of two catalytic domains to produce a single competent active site and a novel discrete bicarbonate binding pocket. Crystal structures of the apo protein, the protein in complex with alpha,beta-methylene adenosine 5'-triphosphate (AMPCPP) and calcium, with the allosteric activator bicarbonate, and also with a number of inhibitors identified using fragment screening, all show a flexible active site that undergoes significant conformational changes on binding of ligands. The resulting nanomolar-potent inhibitors that were developed bind at both the substrate binding pocket and the allosteric site, and can be used as chemical probes to further elucidate the function of this protein.

-	~~==About this~~ Structure==	+	Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket.,Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H ChemMedChem. 2014 Feb 24. doi: 10.1002/cmdc.201300480. PMID:24616449<ref>PMID:24616449</ref>
-	~~[[4oyi]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4OYI OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024616449</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
		+	[[Category: Human]]
	[[Category: Vinkovic, M.]]		[[Category: Vinkovic, M.]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 09:22, 2 April 2014

2014-04-02T09:22:03Z

←Older revision		Revision as of 09:22, 2 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4oyi\| PDB=4oyi \| SCENE= }}
		+	===Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone===
		+	{{ABSTRACT_PUBMED_24616449}}

-	~~The entry 4oyi~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.

-	~~Authors~~: ~~Vinkovic~~, M.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>

-	~~Description~~: ~~Human solAC Complexed with (4~~-~~Amino-furazan-3-yl)-phenyl-methanone~~	+	==About this Structure==
		+	[[4oyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024616449</ref><references group="xtra"/><references/>
		+	[[Category: Adenylate cyclase]]
		+	[[Category: Vinkovic, M.]]
		+	[[Category: Lyase]]

OCA at 12:24, 12 March 2014

2014-03-12T12:24:22Z

←Older revision		Revision as of 12:24, 12 March 2014
Line 5:		Line 5:
	Authors: Vinkovic, M.		Authors: Vinkovic, M.

-	Description: ~~Crystal Structure Analysis of the~~ solAC	+	Description: Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone

OCA: Protected "4oyi" [edit=sysop:move=sysop]

2014-02-19T16:26:16Z

Protected "4oyi" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4oyi is ON HOLD Authors: Vinkovic, M. Description: Crystal Structure Analysis of the solAC

2014-02-19T16:26:15Z

New page: '''Unreleased structure''' The entry 4oyi is ON HOLD Authors: Vinkovic, M. Description: Crystal Structure Analysis of the solAC

New page

'''Unreleased structure'''

The entry 4oyi is ON HOLD

Authors: Vinkovic, M.

Description: Crystal Structure Analysis of the solAC