4p0k - Revision history

OCA at 07:08, 27 September 2023

2023-09-27T07:08:15Z

←Older revision		Revision as of 07:08, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [https://pdbe.org/4p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [https://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [https://pdbe.org/4p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [https://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 12:35, 1 February 2023

2023-02-01T12:35:30Z

←Older revision		Revision as of 12:35, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p0k' size='340' side='right'caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4p0k' size='340' side='right'caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [https://pdbe.org/4p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [https://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [~~http~~://pdbe.org/4p0k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.	+	[https://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.[https://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guenther, S]]	+	[[Category: Guenther S]]
-	[[Category: Sundberg~~, E J]]~~	+	[[Category: Sundberg EJ]]
-	~~[[Category: Chimeric protein]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Interleukin~~]]	+

OCA at 07:50, 17 April 2019

2019-04-17T07:50:20Z

←Older revision		Revision as of 07:50, 17 April 2019
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	==Crystal Structure of Double Loop-Swapped Interleukin-36Ra==		==Crystal Structure of Double Loop-Swapped Interleukin-36Ra==
-	<StructureSection load='4p0k' size='340' side='right' caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4p0k' size='340' side='right'caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://pdbe.org/4p0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://pdbe.org/4p0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4p0k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p0k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin receptor antagonist\|Interleukin receptor antagonist]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Guenther, S]]		[[Category: Guenther, S]]
	[[Category: Sundberg, E J]]		[[Category: Sundberg, E J]]
	[[Category: Chimeric protein]]		[[Category: Chimeric protein]]
		+	[[Category: Cytokine]]
	[[Category: Interleukin]]		[[Category: Interleukin]]

OCA at 20:02, 11 August 2016

2016-08-11T20:02:56Z

←Older revision		Revision as of 20:02, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Double Loop-Swapped Interleukin-36Ra==		==Crystal Structure of Double Loop-Swapped Interleukin-36Ra==
	<StructureSection load='4p0k' size='340' side='right' caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4p0k' size='340' side='right' caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://pdbe.org/4p0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0k ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p0k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:51, 5 January 2015

2015-01-05T12:51:49Z

←Older revision		Revision as of 12:51, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guenther, S.]]	+	[[Category: Guenther, S]]
-	[[Category: Sundberg, E J.]]	+	[[Category: Sundberg, E J]]
	[[Category: Chimeric protein]]		[[Category: Chimeric protein]]
	[[Category: Interleukin]]		[[Category: Interleukin]]

OCA at 06:22, 25 June 2014

2014-06-25T06:22:27Z

←Older revision		Revision as of 06:22, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Double Loop-Swapped Interleukin-36Ra==
		+	<StructureSection load='4p0k' size='340' side='right' caption='[[4p0k]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p0k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0j\|4p0j]], [[4p0l\|4p0l]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p0k RCSB], [http://www.ebi.ac.uk/pdbsum/4p0k PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The IL-1 family consists of 11 cytokines that control a complex network of proinflammatory signals critical for regulating immune responses to infections. They also play a central role in numerous chronic inflammatory disorders. Accordingly, inhibiting the activities of these cytokines is an important therapeutic strategy for treating autoimmune diseases and lymphomas. Agonist cytokines in the IL-1 family activate signaling by binding their cognate receptor and then recruiting a receptor accessory protein. Conversely, antagonist cytokines bind their cognate receptor but prohibit recruitment of receptor accessory protein, which precludes functional signaling complexes. The IL-36 subfamily of cytokines is the most diverse, including three agonists and at least one antagonist, and is the least well-characterized group within this family. Signaling through the IL-36 receptor directly stimulates dendritic cells and primes naive CD4 T cells for Th1 responses. Appropriately balanced IL-36 signaling is a critical determinant of skin and lung health. IL-36 signaling has been presumed to function analogously to IL-1 signaling. In this study, we have defined molecular determinants of agonist and antagonist signaling through the IL-36 receptor. We present the crystal structure of IL-36gamma, which, to our knowledge, is the first reported structure of an IL-36 agonist. Using this structure as a guide, we designed a comprehensive series of IL-36 agonist/antagonist chimeric proteins for which we measured binding to the IL-36 receptor/IL-1 receptor accessory protein complex and functional activation and inhibition of signaling. Our data reveal how the fine specificity of IL-36 signaling is distinct from that of IL-1.

-	~~The entry 4p0k is ON HOLD until Paper Publication~~	+	Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor.,Gunther S, Sundberg EJ J Immunol. 2014 Jun 16. pii: 1400538. PMID:24935927<ref>PMID:24935927</ref>

-	~~Authors~~: Guenther, S., Sundberg, E.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of Double Loop-Swapped~~ Interleukin~~-36Ra~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guenther, S.]]
		+	[[Category: Sundberg, E J.]]
		+	[[Category: Chimeric protein]]
		+	[[Category: Interleukin]]

OCA: Protected "4p0k" [edit=sysop:move=sysop]

2014-03-12T12:26:41Z

Protected "4p0k" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:26, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p0k is ON HOLD until Paper Publication Authors: Guenther, S., Sundberg, E.J. Description: Crystal Structure of Double Loop-Swapped Interleukin-36R...

2014-03-12T12:26:40Z

New page: '''Unreleased structure''' The entry 4p0k is ON HOLD until Paper Publication Authors: Guenther, S., Sundberg, E.J. Description: Crystal Structure of Double Loop-Swapped Interleukin-36R...

New page

'''Unreleased structure'''

The entry 4p0k is ON HOLD until Paper Publication

Authors: Guenther, S., Sundberg, E.J.

Description: Crystal Structure of Double Loop-Swapped Interleukin-36Ra