4p3c - Revision history

OCA at 07:10, 27 September 2023

2023-09-27T07:10:24Z

←Older revision		Revision as of 07:10, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.943Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [https://pdbe.org/4p3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [https://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [https://pdbe.org/4p3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [https://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:39, 1 February 2023

2023-02-01T12:39:45Z

←Older revision		Revision as of 12:39, 1 February 2023
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	==MT1-MMP:Fab complex (Form I)==		==MT1-MMP:Fab complex (Form I)==
-	<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='4p3c' size='340' side='right'caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P3C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [https://pdbe.org/4p3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [https://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [~~http~~://pdbe.org/4p3c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN]] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref>	+	[https://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[3D structures of antibody\|3D structures of antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Membrane-type matrix metalloproteinase-1~~]]	+	[[Category: Mus musculus]]
-	[[Category: Rozenberg, H]]	+	[[Category: Rozenberg H]]
-	[[Category: Sagi, I]]	+	[[Category: Sagi I]]
-	[[Category: Udi, Y]]	+	[[Category: Udi Y]]
-	~~[[Category: Immune system~~]]	+

OCA at 11:56, 6 November 2017

2017-11-06T11:56:43Z

←Older revision		Revision as of 11:56, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://pdbe.org/4p3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://pdbe.org/4p3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4p3c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p3c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Membrane-type matrix metalloproteinase-1]]		[[Category: Membrane-type matrix metalloproteinase-1]]
	[[Category: Rozenberg, H]]		[[Category: Rozenberg, H]]

OCA at 17:15, 4 January 2017

2017-01-04T17:15:45Z

←Older revision		Revision as of 17:15, 4 January 2017
Line 1:		Line 1:
		+
	==MT1-MMP:Fab complex (Form I)==		==MT1-MMP:Fab complex (Form I)==
	<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://pdbe.org/4p3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p3c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:48, 25 December 2014

2014-12-25T08:48:51Z

←Older revision		Revision as of 08:48, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN]] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:46, 17 December 2014

2014-12-17T12:46:15Z

←Older revision		Revision as of 12:46, 17 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==MT1-MMP:Fab complex (Form I)==
		+	<StructureSection load='4p3c' size='340' side='right' caption='[[4p3c]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p3c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ouu\|4ouu]], [[4p3d\|4p3d]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane-type_matrix_metalloproteinase-1 Membrane-type matrix metalloproteinase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.80 3.4.24.80] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3c RCSB], [http://www.ebi.ac.uk/pdbsum/4p3c PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Membrane type 1 metalloprotease (MT1-MMP) is a membrane-anchored, zinc-dependent protease. MT1-MMP is an important mediator of cell migration and invasion, and overexpression of this enzyme has been correlated with the malignancy of various tumor types. Therefore, modulators of MT1-MMP activity are proposed to possess therapeutic potential in numerous invasive diseases. Here we report the inhibition mode of MT1-MMP by LEM-2/15 antibody, which targets a surface epitope of MT1-MMP. Specifically, the crystal structures of Fab LEM-2/15 in complex with the MT1-MMP surface antigen suggest that conformational swiveling of the enzyme surface loop is required for effective binding and consequent inhibition of MT1-MMP activity on the cell membrane. This inhibition mechanism appears to be effective in controlling active MT1-MMP in endothelial cells and at the leading edge of migratory cancer cells.

-	~~The entry 4p3c is ON HOLD until Paper Publication~~	+	Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.,Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I Structure. 2014 Dec 3. pii: S0969-2126(14)00357-8. doi:, 10.1016/j.str.2014.10.012. PMID:25482542<ref>PMID:25482542</ref>

-	~~Authors: Rozenberg~~, H.~~, Udi, Y~~.~~, Sagi, I~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~MT1~~-~~MMP~~:~~Fab complex (Form~~ I)	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Membrane-type matrix metalloproteinase-1]]
		+	[[Category: Rozenberg, H]]
		+	[[Category: Sagi, I]]
		+	[[Category: Udi, Y]]
		+	[[Category: Immune system]]

OCA at 07:58, 21 May 2014

2014-05-21T07:58:28Z

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-	The entry 4p3c is ON HOLD	+	The entry 4p3c is ON HOLD until Paper Publication

	Authors: Rozenberg, H., Udi, Y., Sagi, I.		Authors: Rozenberg, H., Udi, Y., Sagi, I.

	Description: MT1-MMP:Fab complex (Form I)		Description: MT1-MMP:Fab complex (Form I)

OCA: Protected "4p3c" [edit=sysop:move=sysop]

2014-03-12T12:31:24Z

Protected "4p3c" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:31, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p3c is ON HOLD Authors: Rozenberg, H., Udi, Y., Sagi, I. Description: MT1-MMP:Fab complex (Form I)

2014-03-12T12:31:22Z

New page: '''Unreleased structure''' The entry 4p3c is ON HOLD Authors: Rozenberg, H., Udi, Y., Sagi, I. Description: MT1-MMP:Fab complex (Form I)

New page

'''Unreleased structure'''

The entry 4p3c is ON HOLD

Authors: Rozenberg, H., Udi, Y., Sagi, I.

Description: MT1-MMP:Fab complex (Form I)