4p3y - Revision history

OCA at 09:13, 25 October 2023

2023-10-25T09:13:58Z

←Older revision		Revision as of 09:13, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE] and [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE] and [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.154Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [https://pdbe.org/4p3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [https://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [https://pdbe.org/4p3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [https://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:40, 1 February 2023

2023-02-01T12:40:31Z

←Older revision		Revision as of 12:40, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p3y' size='340' side='right'caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4p3y' size='340' side='right'caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aciby Aciby~~] and [~~http~~://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE] and [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dsbA, ABAYE3833 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 ACIBY])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [https://pdbe.org/4p3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [https://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [~~http~~://pdbe.org/4p3y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C6EGC5_ECOBD C6EGC5_ECOBD]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity).[RuleBase:RU000325][HAMAP-Rule:MF_00118]	+	[https://www.uniprot.org/uniprot/B0V5X3_ACIBY B0V5X3_ACIBY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aciby]]~~	+	[[Category: Acinetobacter baumannii AYE]]
-	~~[[Category: Escherichia coli~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Martin~~, J L~~]]	+	[[Category: Martin JL]]
-	[[Category: Premkumar, L]]	+	[[Category: Premkumar L]]
-	~~[[Category: Anti-biofilm formation]]~~	+
-	~~[[Category: Antivirulence]]~~	+
-	~~[[Category: Bacterial infection]]~~	+
-	~~[[Category: Disulfide bond formation]]~~	+
-	~~[[Category: Disulfide oxidase dsba]]~~	+
-	~~[[Category: Multidrug resistance]]~~	+
-	~~[[Category: Thioredoxin related]]~~	+
-	~~[[Category: Translation-oxidoreductase complex~~]]	+

OCA at 08:39, 1 January 2020

2020-01-01T08:39:50Z

←Older revision		Revision as of 08:39, 1 January 2020
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Elongation factor\|Elongation factor]]	+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:30, 17 April 2019

2019-04-17T07:30:08Z

←Older revision		Revision as of 07:30, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu==		==Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu==
-	<StructureSection load='4p3y' size='340' side='right' caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='4p3y' size='340' side='right'caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciby Aciby] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dsbA, ABAYE3833 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=509173 ACIBY])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://pdbe.org/4p3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://pdbe.org/4p3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aciby]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: Martin, J L]]		[[Category: Martin, J L]]
	[[Category: Premkumar, L]]		[[Category: Premkumar, L]]

OCA at 22:31, 5 August 2016

2016-08-05T22:31:54Z

←Older revision		Revision as of 22:31, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu==		==Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu==
	<StructureSection load='4p3y' size='340' side='right' caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='4p3y' size='340' side='right' caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://pdbe.org/4p3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p3y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Elongation factor\|Elongation factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:24, 25 December 2014

2014-12-25T06:24:41Z

←Older revision		Revision as of 06:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C6EGC5_ECOBD C6EGC5_ECOBD]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity).[RuleBase:RU000325][HAMAP-Rule:MF_00118]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Martin, J L.]]	+	[[Category: Martin, J L]]
-	[[Category: Premkumar, L.]]	+	[[Category: Premkumar, L]]
	[[Category: Anti-biofilm formation]]		[[Category: Anti-biofilm formation]]
	[[Category: Antivirulence]]		[[Category: Antivirulence]]

OCA at 08:00, 18 June 2014

2014-06-18T08:00:29Z

←Older revision		Revision as of 08:00, 18 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu==
		+	<StructureSection load='4p3y' size='340' side='right' caption='[[4p3y]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3y RCSB], [http://www.ebi.ac.uk/pdbsum/4p3y PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The multidrug resistant bacterium Acinetobacter baumannii is a significant cause of nosocomial infection. Biofilm formation - that requires both disulfide bond forming and chaperone-usher pathways - is a major virulence trait in this bacterium. Our biochemical characterizations show that the periplasmic A. baumannii DsbA (AbDsbA) enzyme has an oxidizing redox potential and dithiol oxidase activity. We found an unexpected non-covalent interaction between AbDsbA and the highly conserved prokaryotic elongation factor, EF-Tu. EF-Tu is a cytoplasmic protein but has been localized extracellularly in many bacterial pathogens. The crystal structure of this complex revealed that the EF-Tu switch I region binds to the non-catalytic surface of AbDsbA. Though the physiological and pathological significance of a DsbA/EF-Tu association is unknown, peptides derived from the EF-Tu switch I region bound to AbDsbA with submicromolar affinity. We also identified a 7-residue DsbB-derived peptide that bound to AbDsbA with low micromolar affinity. Further characterization confirmed that the EF-Tu and DsbB derived peptides bind at two distinct sites. These data point to the possibility that the non-catalytic surface of DsbA is a potential substrate or regulatory protein interaction site. The two peptides identified in this work, together with the newly characterized interaction site, provide a novel starting point for inhibitor design targeting AbDsbA.

-	~~The entry 4p3y is ON HOLD until Paper Publication~~	+	Structure of the Acinetobacter Baumannii Dithiol Oxidase DsbA Bound to EF-Tu Reveals a Novel Protein Interaction Site.,Premkumar L, Kurth F, Duprez W, Groftehauge MK, King GJ, Halili MA, Heras B, Martin JL J Biol Chem. 2014 May 23. pii: jbc.M114.571737. PMID:24860094<ref>PMID:24860094</ref>

-	~~Authors: Premkumar~~, L., Martin, J.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Acinetobacter baumannii DsbA in complex with EF~~-Tu	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Martin, J L.]]
		+	[[Category: Premkumar, L.]]
		+	[[Category: Anti-biofilm formation]]
		+	[[Category: Antivirulence]]
		+	[[Category: Bacterial infection]]
		+	[[Category: Disulfide bond formation]]
		+	[[Category: Disulfide oxidase dsba]]
		+	[[Category: Multidrug resistance]]
		+	[[Category: Thioredoxin related]]
		+	[[Category: Translation-oxidoreductase complex]]

OCA at 08:48, 26 March 2014

2014-03-26T08:48:14Z

←Older revision		Revision as of 08:48, 26 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p3y is ON HOLD	+	The entry 4p3y is ON HOLD until Paper Publication

-	Authors: Premkumar, L, Martin, J.L	+	Authors: Premkumar, L., Martin, J.L.

	Description: Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu		Description: Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu

OCA: Protected "4p3y" [edit=sysop:move=sysop]

2014-03-19T07:33:28Z

Protected "4p3y" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 19 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p3y is ON HOLD Authors: Premkumar, L, Martin, J.L Description: Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu

2014-03-19T07:33:26Z

New page: '''Unreleased structure''' The entry 4p3y is ON HOLD Authors: Premkumar, L, Martin, J.L Description: Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu

New page

'''Unreleased structure'''

The entry 4p3y is ON HOLD

Authors: Premkumar, L, Martin, J.L

Description: Crystal structure of Acinetobacter baumannii DsbA in complex with EF-Tu