4p75 - Revision history

OCA at 07:12, 27 September 2023

2023-09-27T07:12:41Z

←Older revision		Revision as of 07:12, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P75 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P75 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.96Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [https://pdbe.org/4p75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [https://www.ebi.ac.uk/pdbsum/4p75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p75 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [https://pdbe.org/4p75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [https://www.ebi.ac.uk/pdbsum/4p75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p75 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:45, 1 February 2023

2023-02-01T12:45:03Z

←Older revision		Revision as of 12:45, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p75' size='340' side='right'caption='[[4p75]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='4p75' size='340' side='right'caption='[[4p75]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P75 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [https://pdbe.org/4p75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [https://www.ebi.ac.uk/pdbsum/4p75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p75 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pheT, PA2739 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), pheS, PA2740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [~~http~~://pdbe.org/4p75 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p75 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p75 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYFB_PSEAE SYFB_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Phenylalanine--tRNA ligase]]~~	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	~~[[Category: Pseae~~]]	+	[[Category: Ferguson AD]]
-	[[Category: Ferguson~~, A D]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex]]~~	+
-	~~[[Category: Phenylalanine trna synthetase]]~~	+
-	~~[[Category: Pher~~]]	+

OCA at 07:49, 17 April 2019

2019-04-17T07:49:53Z

←Older revision		Revision as of 07:49, 17 April 2019
Line 1:		Line 1:
		+
	==PheRS in complex with compound 4a==		==PheRS in complex with compound 4a==
-	<StructureSection load='4p75' size='340' side='right' caption='[[4p75]], [[Resolution\|resolution]] 2.96Å' scene=''>	+	<StructureSection load='4p75' size='340' side='right'caption='[[4p75]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P75 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pheT, PA2739 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), pheS, PA2740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://pdbe.org/4p75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://pdbe.org/4p75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p75 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4p75" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p75" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Phenylalanine--tRNA ligase]]		[[Category: Phenylalanine--tRNA ligase]]
		+	[[Category: Pseae]]
	[[Category: Ferguson, A D]]		[[Category: Ferguson, A D]]
	[[Category: Ligase-ligase inhibitor complex]]		[[Category: Ligase-ligase inhibitor complex]]
	[[Category: Phenylalanine trna synthetase]]		[[Category: Phenylalanine trna synthetase]]
	[[Category: Pher]]		[[Category: Pher]]

OCA at 07:17, 30 September 2015

2015-09-30T07:17:59Z

←Older revision		Revision as of 07:17, 30 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://pdbe.org/4p75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p75" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:31, 20 January 2015

2015-01-20T11:31:21Z

←Older revision		Revision as of 11:31, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P75 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P75 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Phenylalanine--tRNA ligase]]		[[Category: Phenylalanine--tRNA ligase]]
-	[[Category: Ferguson, A D.]]	+	[[Category: Ferguson, A D]]
	[[Category: Ligase-ligase inhibitor complex]]		[[Category: Ligase-ligase inhibitor complex]]
	[[Category: Phenylalanine trna synthetase]]		[[Category: Phenylalanine trna synthetase]]
	[[Category: Pher]]		[[Category: Pher]]

OCA at 06:22, 25 June 2014

2014-06-25T06:22:29Z

←Older revision		Revision as of 06:22, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==PheRS in complex with compound 4a==
		+	<StructureSection load='4p75' size='340' side='right' caption='[[4p75]], [[Resolution\|resolution]] 2.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p75]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P75 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NM:3-(3-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE'>2NM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p71\|4p71]], [[4p72\|4p72]], [[4p73\|4p73]], [[4p74\|4p74]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p75 RCSB], [http://www.ebi.ac.uk/pdbsum/4p75 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The antimicrobial activity of phenyl-thiazolylurea-sulfonamides against S. aureus PheRS are dependent upon phenylalanine levels in the extracellular fluids. Inhibitor efficacy in animal models of infection is substantially diminished by dietary phenylalanine intake, thereby reducing the perceived clinical utility of this inhibitor class. The search for novel antibacterial compounds against Gram-negative pathogens led to a re-evaluation of this phenomenon, which is shown here to be unique to S. aureus. Inhibition of macromolecular syntheses and characterization of novel resistance mutations in Escherichia coli demonstrate that antimicrobial activity of phenyl-thiazolylurea-sulfonamides is mediated by PheRS inhibition, validating this enzyme as a viable drug discovery target for Gram-negative pathogens. A search for novel inhibitors of PheRS yielded three novel chemical starting points. NMR studies were used to confirm direct target engagement for phenylalanine-competitive hits. The crystallographic structure of P. aeruginosa PheRS defined the binding modes of these hits, and revealed an auxiliary hydrophobic pocket that is positioned adjacent to the phenylalanine binding site. Three viable inhibitor-resistant mutants were mapped to this pocket, suggesting that this region is a potential liability for drug discovery.

-	The ~~entry 4p75 is ON HOLD until Paper Publication~~	+	The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability.,Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET J Biol Chem. 2014 Jun 16. pii: jbc.M114.574061. PMID:24936059<ref>PMID:24936059</ref>

-	~~Authors~~: Ferguson, A.D.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~PheRS in~~ complex ~~with compound 4a~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phenylalanine--tRNA ligase]]
		+	[[Category: Ferguson, A D.]]
		+	[[Category: Ligase-ligase inhibitor complex]]
		+	[[Category: Phenylalanine trna synthetase]]
		+	[[Category: Pher]]

OCA at 06:25, 30 April 2014

2014-04-30T06:25:44Z

←Older revision		Revision as of 06:25, 30 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p75 is ON HOLD	+	The entry 4p75 is ON HOLD until Paper Publication

	Authors: Ferguson, A.D.		Authors: Ferguson, A.D.

	Description: PheRS in complex with compound 4a		Description: PheRS in complex with compound 4a

OCA at 07:22, 23 April 2014

2014-04-23T07:22:37Z

←Older revision		Revision as of 07:22, 23 April 2014
Line 3:		Line 3:
	The entry 4p75 is ON HOLD		The entry 4p75 is ON HOLD

-	Authors: Ferguson, AD	+	Authors: Ferguson, A.D.

-	Description: PheRS	+	Description: PheRS in complex with compound 4a

OCA: Protected "4p75" [edit=sysop:move=sysop]

2014-04-02T08:30:59Z

Protected "4p75" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 2 April 2014

OCA: New page: '''Unreleased structure''' The entry 4p75 is ON HOLD Authors: Ferguson, AD Description: PheRS

2014-04-02T08:30:58Z

New page: '''Unreleased structure''' The entry 4p75 is ON HOLD Authors: Ferguson, AD Description: PheRS

New page

'''Unreleased structure'''

The entry 4p75 is ON HOLD

Authors: Ferguson, AD

Description: PheRS