4p9o - Revision history

OCA at 00:41, 28 December 2023

2023-12-28T00:41:45Z

←Older revision		Revision as of 00:41, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [https://pdbe.org/4p9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [https://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [https://pdbe.org/4p9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [https://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:48, 1 February 2023

2023-02-01T12:48:39Z

←Older revision		Revision as of 12:48, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p9o' size='340' side='right'caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='4p9o' size='340' side='right'caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Magmm Magmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [https://pdbe.org/4p9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [https://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mmc1_0798 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=156889 MAGMM])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [~~http~~://pdbe.org/4p9o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0L5S6_MAGMM A0L5S6_MAGMM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4p9o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p9o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Magmm~~]]	+	[[Category: Magnetococcus marinus MC-1]]
-	[[Category: Bagneris, C]]	+	[[Category: Bagneris C]]
-	[[Category: Naylor~~, C E~~]]	+	[[Category: Naylor CE]]
-	[[Category: Wallace~~, B A]]~~	+	[[Category: Wallace BA]]
-	~~[[Category: Channel blocker]]~~	+
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:39, 1 January 2020

2020-01-01T08:39:56Z

←Older revision		Revision as of 08:39, 1 January 2020
Line 1:		Line 1:

	==Complex of Voltage-gated ion channel in a the presence of channel blocking compound==		==Complex of Voltage-gated ion channel in a the presence of channel blocking compound==
-	<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>	+	<StructureSection load='4p9o' size='340' side='right'caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Magmm]]		[[Category: Magmm]]
	[[Category: Bagneris, C]]		[[Category: Bagneris, C]]

OCA at 14:47, 15 November 2017

2017-11-15T14:47:17Z

←Older revision		Revision as of 14:47, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mmc1_0798 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=156889 MAGMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://pdbe.org/4p9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://pdbe.org/4p9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Magmm]]
	[[Category: Bagneris, C]]		[[Category: Bagneris, C]]
	[[Category: Naylor, C E]]		[[Category: Naylor, C E]]
Line 27:		Line 29:
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 15:44, 11 August 2016

2016-08-11T15:44:47Z

←Older revision		Revision as of 15:44, 11 August 2016
Line 1:		Line 1:
		+
	==Complex of Voltage-gated ion channel in a the presence of channel blocking compound==		==Complex of Voltage-gated ion channel in a the presence of channel blocking compound==
	<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://pdbe.org/4p9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p9o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:57, 5 January 2015

2015-01-05T14:57:37Z

←Older revision		Revision as of 14:57, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bagneris, C.]]	+	[[Category: Bagneris, C]]
-	[[Category: Naylor, C E.]]	+	[[Category: Naylor, C E]]
-	[[Category: Wallace, B A.]]	+	[[Category: Wallace, B A]]
	[[Category: Channel blocker]]		[[Category: Channel blocker]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 07:05, 11 June 2014

2014-06-11T07:05:00Z

←Older revision		Revision as of 07:05, 11 June 2014
Line 13:		Line 13:
	Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>		Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 05:08, 4 June 2014

2014-06-04T05:08:22Z

←Older revision		Revision as of 05:08, 4 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Complex of Voltage-gated ion channel in a the presence of channel blocking compound==
		+	<StructureSection load='4p9o' size='340' side='right' caption='[[4p9o]], [[Resolution\|resolution]] 2.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p9o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4cbd\|4cbd]], [[4p30\|4p30]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9o RCSB], [http://www.ebi.ac.uk/pdbsum/4p9o PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of neurological and cardiovascular diseases. In this study, functional electrophysiological studies show that the prokaryotic sodium channel from Magnetococcus marinus (NavMs) binds and is inhibited by eukaryotic sodium channel blockers in a manner similar to the human Nav1.1 channel, despite millions of years of divergent evolution between the two types of channels. Crystal complexes of the NavMs pore with several brominated blocker compounds depict a common antagonist binding site in the cavity, adjacent to lipid-facing fenestrations proposed to be the portals for drug entry. In silico docking studies indicate the full extent of the blocker binding site, and electrophysiology studies of NavMs channels with mutations at adjacent residues validate the location. These results suggest that the NavMs channel can be a valuable tool for screening and rational design of human drugs.

-	~~The entry 4p9o is ON HOLD until Paper Publication~~	+	Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>

-	~~Authors: Naylor~~, C.E., Bagneris, C., Wallace, B.A.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Complex of Voltage-gated ion~~ channel ~~in a the presence of channel blocking compound~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bagneris, C.]]
		+	[[Category: Naylor, C E.]]
		+	[[Category: Wallace, B A.]]
		+	[[Category: Channel blocker]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]

OCA at 09:04, 16 April 2014

2014-04-16T09:04:12Z

←Older revision		Revision as of 09:04, 16 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p9o is ON HOLD	+	The entry 4p9o is ON HOLD until Paper Publication

	Authors: Naylor, C.E., Bagneris, C., Wallace, B.A.		Authors: Naylor, C.E., Bagneris, C., Wallace, B.A.

	Description: Complex of Voltage-gated ion channel in a the presence of channel blocking compound		Description: Complex of Voltage-gated ion channel in a the presence of channel blocking compound

OCA: Protected "4p9o" [edit=sysop:move=sysop]

2014-04-09T05:55:15Z

Protected "4p9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 9 April 2014