4pd6 - Revision history

OCA at 07:15, 27 September 2023

2023-09-27T07:15:32Z

←Older revision		Revision as of 07:15, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.08Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [https://pdbe.org/4pd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [https://pdbe.org/4pd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:53, 1 February 2023

2023-02-01T12:53:14Z

←Older revision		Revision as of 12:53, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4pd6' size='340' side='right'caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4pd6' size='340' side='right'caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibch Vibch~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [https://pdbe.org/4pd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC_2352 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [~~http~~://pdbe.org/4pd6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9KPL5_VIBCH Q9KPL5_VIBCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vibch~~]]	+	[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
-	[[Category: Johnson~~, Z L~~]]	+	[[Category: Johnson ZL]]
-	[[Category: Lee, S Y]]	+	[[Category: Lee S-Y]]
-	~~[[Category: Drug transporter]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Sodium-coupled transporter]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Uridine~~]]	+

OCA at 10:11, 25 December 2019

2019-12-25T10:11:27Z

←Older revision		Revision as of 10:11, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of vcCNT-7C8C bound to uridine==		==Crystal structure of vcCNT-7C8C bound to uridine==
-	<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>	+	<StructureSection load='4pd6' size='340' side='right'caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Vibch]]		[[Category: Vibch]]
	[[Category: Johnson, Z L]]		[[Category: Johnson, Z L]]

OCA at 14:49, 15 November 2017

2017-11-15T14:49:51Z

←Older revision		Revision as of 14:49, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC_2352 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://pdbe.org/4pd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://pdbe.org/4pd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Vibch]]
	[[Category: Johnson, Z L]]		[[Category: Johnson, Z L]]
	[[Category: Lee, S Y]]		[[Category: Lee, S Y]]

OCA at 12:31, 11 August 2016

2016-08-11T12:31:27Z

←Older revision		Revision as of 12:31, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of vcCNT-7C8C bound to uridine==		==Crystal structure of vcCNT-7C8C bound to uridine==
	<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>		<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://pdbe.org/4pd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pd6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:01, 20 January 2015

2015-01-20T10:01:51Z

←Older revision		Revision as of 10:01, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Johnson, Z L.]]	+	[[Category: Johnson, Z L]]
-	[[Category: Lee, S Y.]]	+	[[Category: Lee, S Y]]
	[[Category: Drug transporter]]		[[Category: Drug transporter]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 09:03, 13 August 2014

2014-08-13T09:03:34Z

←Older revision		Revision as of 09:03, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of vcCNT-7C8C bound to uridine==
		+	<StructureSection load='4pd6' size='340' side='right' caption='[[4pd6]], [[Resolution\|resolution]] 2.08Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PD6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tij\|3tij]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pd6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pd6 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents. Understanding how CNTs recognize and import their substrates could not only lead to a better understanding of nucleoside-related biological processes but also the design of nucleoside-derived drugs that can better reach their targets. Here we present a combination of x-ray crystallographic and equilibrium-binding studies probing the molecular origins of nucleoside and nucleoside drug selectivity of a CNT from Vibrio cholerae. We then used this information in chemically modifying an anticancer drug so that is better transported by and selective for a single human CNT subtype. This work provides proof of principle for utilizing transporter structural and functional information for the design of compounds that enter cells more efficiently and selectively.

-	~~The entry 4pd6 is ON HOLD until Paper Publication~~	+	Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.,Johnson ZL, Lee JH, Lee K, Lee M, Kwon DY, Hong J, Lee SY Elife. 2014 Jul 31:e03604. doi: 10.7554/eLife.03604. PMID:25082345<ref>PMID:25082345</ref>

-	~~Authors~~: Johnson, Z.L., Lee, S.-Y.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Johnson, Z L.]]
		+	[[Category: Lee, S Y.]]
		+	[[Category: Drug transporter]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sodium-coupled transporter]]
		+	[[Category: Transport protein]]
		+	[[Category: Uridine]]

OCA at 07:42, 7 May 2014

2014-05-07T07:42:40Z

←Older revision		Revision as of 07:42, 7 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pd6 is ON HOLD	+	The entry 4pd6 is ON HOLD until Paper Publication

	Authors: Johnson, Z.L., Lee, S.-Y.		Authors: Johnson, Z.L., Lee, S.-Y.

	Description:		Description:

OCA: Protected "4pd6" [edit=sysop:move=sysop]

2014-04-23T07:26:38Z

Protected "4pd6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 4pd6 is ON HOLD Authors: Johnson, Z.L., Lee, S.-Y. Description:

2014-04-23T07:26:37Z

New page: '''Unreleased structure''' The entry 4pd6 is ON HOLD Authors: Johnson, Z.L., Lee, S.-Y. Description:

New page

'''Unreleased structure'''

The entry 4pd6 is ON HOLD

Authors: Johnson, Z.L., Lee, S.-Y.

Description: