4ph4 - Revision history

OCA at 00:43, 28 December 2023

2023-12-28T00:43:50Z

←Older revision		Revision as of 00:43, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [https://pdbe.org/4ph4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [https://pdbe.org/4ph4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:02, 1 February 2023

2023-02-01T13:02:13Z

←Older revision		Revision as of 13:02, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4ph4' size='340' side='right'caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ph4' size='340' side='right'caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, VPS34 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [https://pdbe.org/4ph4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [~~http~~://pdbe.org/4ph4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>	+	[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphoinositide 3-~~Kinases~~\|Phosphoinositide 3-~~Kinases~~]]	+	*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphatidylinositol 3-kinase]]~~	+	[[Category: Elling RA]]
-	[[Category: Elling~~, R A~~]]	+	[[Category: Knapp MS]]
-	[[Category: Knapp~~, M S]]~~	+
-	~~[[Category: Autophagy]]~~	+
-	~~[[Category: Class iii]]~~	+
-	~~[[Category: Phosphatidylinositol-3-kinase]]~~	+
-	~~[[Category: Pik3c3]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex]]~~	+
-	~~[[Category: Vps34~~]]	+

OCA at 07:48, 17 April 2019

2019-04-17T07:48:30Z

←Older revision		Revision as of 07:48, 17 April 2019
Line 1:		Line 1:

	==The crystal structure of Human VPS34 in complex with PIK-III==		==The crystal structure of Human VPS34 in complex with PIK-III==
-	<StructureSection load='4ph4' size='340' side='right' caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4ph4' size='340' side='right'caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, VPS34 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://pdbe.org/4ph4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://pdbe.org/4ph4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]
	[[Category: Elling, R A]]		[[Category: Elling, R A]]
Line 33:		Line 36:
	[[Category: Phosphatidylinositol-3-kinase]]		[[Category: Phosphatidylinositol-3-kinase]]
	[[Category: Pik3c3]]		[[Category: Pik3c3]]
		+	[[Category: Transferase-transferase inhibitor complex]]
	[[Category: Vps34]]		[[Category: Vps34]]

OCA at 09:26, 11 August 2016

2016-08-11T09:26:21Z

←Older revision		Revision as of 09:26, 11 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of Human VPS34 in complex with PIK-III==		==The crystal structure of Human VPS34 in complex with PIK-III==
	<StructureSection load='4ph4' size='340' side='right' caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ph4' size='340' side='right' caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://pdbe.org/4ph4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ph4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:16, 25 December 2014

2014-12-25T08:16:15Z

←Older revision		Revision as of 08:16, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:45, 12 November 2014

2014-11-12T07:45:09Z

←Older revision		Revision as of 07:45, 12 November 2014
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]
-	[[Category: Elling, R A.]]	+	[[Category: Elling, R A]]
-	[[Category: Knapp, M S.]]	+	[[Category: Knapp, M S]]
	[[Category: Autophagy]]		[[Category: Autophagy]]
	[[Category: Class iii]]		[[Category: Class iii]]

OCA at 06:39, 5 November 2014

2014-11-05T06:39:44Z

←Older revision		Revision as of 06:39, 5 November 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kalpha. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. By performing ubiquitin-affinity proteomics on PIK-III-treated cells we identified substrates including NCOA4, which accumulates in ATG7-deficient cells and co-localizes with autolysosomes. NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to autolysosomes following starvation or iron depletion. Interestingly, Ncoa4(-/-) mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells. Taken together, the results of this study provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo.
		+
		+	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.,Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO Nat Cell Biol. 2014 Nov;16(11):1069-79. doi: 10.1038/ncb3053. Epub 2014 Oct 19. PMID:25327288<ref>PMID:25327288</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:28, 29 October 2014

2014-10-29T11:28:33Z

←Older revision		Revision as of 11:28, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The crystal structure of Human VPS34 in complex with PIK-III==
-		+	<StructureSection load='4ph4' size='340' side='right' caption='[[4ph4]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~The entry~~ 4ph4 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ph4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH4 FirstGlance]. <br>
-	~~Authors~~: ~~Knapp~~, M.S., Elling, R.A.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UG:4-(CYCLOPROPYLMETHYL)-N~2~-(PYRIDIN-4-YL)-4,5-BIPYRIMIDINE-2,2-DIAMINE'>2UG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
-	~~Description~~: ~~The crystal structure of Human VPS34 in complex with PIK~~-~~III~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph4 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphatidylinositol 3-kinase]]
		+	[[Category: Elling, R A.]]
		+	[[Category: Knapp, M S.]]
		+	[[Category: Autophagy]]
		+	[[Category: Class iii]]
		+	[[Category: Phosphatidylinositol-3-kinase]]
		+	[[Category: Pik3c3]]
		+	[[Category: Vps34]]

OCA at 07:59, 24 September 2014

2014-09-24T07:59:09Z

←Older revision		Revision as of 07:59, 24 September 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ph4 is ON HOLD	+	The entry 4ph4 is ON HOLD until Paper Publication

	Authors: Knapp, M.S., Elling, R.A.		Authors: Knapp, M.S., Elling, R.A.

	Description: The crystal structure of Human VPS34 in complex with PIK-III		Description: The crystal structure of Human VPS34 in complex with PIK-III

OCA: Protected "4ph4" [edit=sysop:move=sysop]

2014-05-14T07:08:06Z

Protected "4ph4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:08, 14 May 2014