4phk - Revision history

OCA at 11:18, 9 May 2024

2024-05-09T11:18:24Z

←Older revision		Revision as of 11:18, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [https://pdbe.org/4phk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [https://www.ebi.ac.uk/pdbsum/4phk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [https://pdbe.org/4phk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [https://www.ebi.ac.uk/pdbsum/4phk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:03, 1 February 2023

2023-02-01T13:03:45Z

←Older revision		Revision as of 13:03, 1 February 2023
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	<StructureSection load='4phk' size='340' side='right'caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4phk' size='340' side='right'caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [https://pdbe.org/4phk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [https://www.ebi.ac.uk/pdbsum/4phk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [~~http~~://pdbe.org/4phk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4phk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4phk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CPNS1_HUMAN CPNS1_HUMAN]] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.	+	[https://www.uniprot.org/uniprot/CPNS1_HUMAN CPNS1_HUMAN] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams~~, S E~~]]	+	[[Category: Adams SE]]
-	[[Category: Allemann~~, R K~~]]	+	[[Category: Allemann RK]]
-	[[Category: Hallett~~, M B~~]]	+	[[Category: Hallett MB]]
-	[[Category: Miller~~, D J~~]]	+	[[Category: Miller DJ]]
-	[[Category: Rizkallah~~, P J~~]]	+	[[Category: Rizkallah PJ]]
-	[[Category: Robinson, E]]	+	[[Category: Robinson E]]
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Domain vi]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 07:16, 10 July 2019

2019-07-10T07:16:42Z

←Older revision		Revision as of 07:16, 10 July 2019
Line 1:		Line 1:

	==The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid==		==The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid==
-	<StructureSection load='4phk' size='340' side='right' caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4phk' size='340' side='right'caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHK FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Calpain\|Calpain]]	+	*[[Calpain 3D structures\|Calpain 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adams, S E]]		[[Category: Adams, S E]]
	[[Category: Allemann, R K]]		[[Category: Allemann, R K]]

OCA at 17:05, 4 January 2017

2017-01-04T17:05:52Z

←Older revision		Revision as of 17:05, 4 January 2017
Line 1:		Line 1:
		+
	==The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid==		==The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid==
	<StructureSection load='4phk' size='340' side='right' caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4phk' size='340' side='right' caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [http://www.ebi.ac.uk/pdbsum/4phk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [http://pdbe.org/4phk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [http://www.ebi.ac.uk/pdbsum/4phk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4phk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4phk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:02, 18 March 2015

2015-03-18T12:02:50Z

←Older revision		Revision as of 12:02, 18 March 2015
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Calpain\|Calpain]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:28, 25 December 2014

2014-12-25T11:28:31Z

←Older revision		Revision as of 11:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [http://www.ebi.ac.uk/pdbsum/4phk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [http://www.ebi.ac.uk/pdbsum/4phk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPNS1_HUMAN CPNS1_HUMAN]] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adams, S E.]]	+	[[Category: Adams, S E]]
-	[[Category: Allemann, R K.]]	+	[[Category: Allemann, R K]]
-	[[Category: Hallett, M B.]]	+	[[Category: Hallett, M B]]
-	[[Category: Miller, D J.]]	+	[[Category: Miller, D J]]
-	[[Category: Rizkallah, P J.]]	+	[[Category: Rizkallah, P J]]
-	[[Category: Robinson, E.]]	+	[[Category: Robinson, E]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Domain vi]]		[[Category: Domain vi]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 22:06, 1 October 2014

2014-10-01T22:06:23Z

←Older revision		Revision as of 22:06, 1 October 2014
Line 23:		Line 23:
	[[Category: Hallett, M B.]]		[[Category: Hallett, M B.]]
	[[Category: Miller, D J.]]		[[Category: Miller, D J.]]
-	[[Category: Rizkallah, P J]]	+	[[Category: Rizkallah, P J.]]
	[[Category: Robinson, E.]]		[[Category: Robinson, E.]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]

OCA at 09:06, 13 August 2014

2014-08-13T09:06:38Z

←Older revision		Revision as of 09:06, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic Acids. The complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid==
		+	<StructureSection load='4phk' size='340' side='right' caption='[[4phk]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4phk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UB:(Z)-3-(4-CHLOROPHENYL)-2-MERCAPTOACRYLIC+ACID'>2UB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4phj\|4phj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phk RCSB], [http://www.ebi.ac.uk/pdbsum/4phk PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Excessive activity of neutrophils has been linked to many pathological conditions, including rheumatoid arthritis, cancer and Alzheimer's disease. Calpain-I is a Ca2+-dependent protease that plays a key role in the extravasation of neutrophils from the blood stream prior to causing damage within affected tissues. Inhibition of calpain-I with small molecule mercaptoacrylic acid derivatives slows the cell spreading process of live neutrophils and so these compounds represent promising drug leads. Here we present the 2.05 and 2.03A co-crystal X-ray structures of the pentaEF hand region PEF(S) from human calpain with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid and (Z)-3-(5-bromoindol-3-yl)-2-mercaptoacrylic acid. In both structures, the alpha-mercaptoacrylic acid derivatives bind between two alpha-helices in a hydrophobic pocket that is also exploited by a leucine residue of the endogenous regulatory calpain inhibitor calpastatin. Hydrophobic interactions between the aromatic rings of both inhibitors and the aliphatic residues of the pocket are integral for tight binding. In the case of (Z)-3-(5-bromoindol-3-yl)-2-mercaptoacrylic acid, hydrogen bonds form between the mercaptoacrylic acid substituent lying outside the pocket and the protein and the carboxylate group is coplanar with the aromatic ring system. Multiple conformations of (Z)-3-(5-bromoindol-3-yl)-2-mercaptoacrylic acid were found within the pocket. The increased potency of (Z)-3-(5-bromoindol-3-yl)-2-mercaptoacrylic acid relative to (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid may be a consequence of the indole group binding more deeply in the hydrophobic pocket of PEF(S) than the phenyl ring.

-	The ~~entry 4phk is ON HOLD until Paper Publication~~	+	The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.,Adams SE, Rizkallah PJ, Miller DJ, Robinson EJ, Hallett MB, Allemann RK J Struct Biol. 2014 Jul 30. pii: S1047-8477(14)00162-2. doi:, 10.1016/j.jsb.2014.07.004. PMID:25086406<ref>PMID:25086406</ref>

-	~~Authors: Rizkallah~~, P.~~J, Allemann, R~~.K., Adams, S.E., ~~Miller, D~~.~~J.,~~ Hallett, M.B., Robinson, E.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic AcidsThe complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adams, S E.]]
		+	[[Category: Allemann, R K.]]
		+	[[Category: Hallett, M B.]]
		+	[[Category: Miller, D J.]]
		+	[[Category: Rizkallah, P J]]
		+	[[Category: Robinson, E.]]
		+	[[Category: Calcium binding]]
		+	[[Category: Domain vi]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protease]]

OCA at 08:03, 21 May 2014

2014-05-21T08:03:59Z

←Older revision		Revision as of 08:03, 21 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4phk is ON HOLD	+	The entry 4phk is ON HOLD until Paper Publication

	Authors: Rizkallah, P.J, Allemann, R.K., Adams, S.E., Miller, D.J., Hallett, M.B., Robinson, E.		Authors: Rizkallah, P.J, Allemann, R.K., Adams, S.E., Miller, D.J., Hallett, M.B., Robinson, E.

	Description: The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic AcidsThe complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid		Description: The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl alpha-Mercaptoacrylic AcidsThe complex with (Z)-3-(4-chlorophenyl)-2-mercaptoacrylic acid

OCA: Protected "4phk" [edit=sysop:move=sysop]

2014-05-14T07:08:22Z

Protected "4phk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:08, 14 May 2014