4phz - Revision history

OCA at 07:17, 27 September 2023

2023-09-27T07:17:07Z

←Older revision		Revision as of 07:17, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylocystis_sp._ATCC_49242 Methylocystis sp. ATCC 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylocystis_sp._ATCC_49242 Methylocystis sp. ATCC 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [https://pdbe.org/4phz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [https://www.ebi.ac.uk/pdbsum/4phz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [https://pdbe.org/4phz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [https://www.ebi.ac.uk/pdbsum/4phz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phz ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:

	==See Also==		==See Also==
-	*[[Methane monooxygenase\|Methane monooxygenase]]	+	*[[Methane monooxygenase 3D structures\|Methane monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:04, 1 February 2023

2023-02-01T13:04:48Z

←Older revision		Revision as of 13:04, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4phz' size='340' side='right'caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4phz' size='340' side='right'caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Methylocystis_sp.~~_atcc_49242~~ Methylocystis sp. ~~atcc~~ 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylocystis_sp._ATCC_49242 Methylocystis sp. ATCC 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [https://pdbe.org/4phz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [https://www.ebi.ac.uk/pdbsum/4phz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4phz ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [~~http~~://pdbe.org/4phz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4phz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4phz ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Methylocystis sp. ~~atcc~~ 49242]]	+	[[Category: Methylocystis sp. ATCC 49242]]
-	[[Category: Rosenzweig~~, A C~~]]	+	[[Category: Rosenzweig AC]]
-	[[Category: Sirajuddin, S]]	+	[[Category: Sirajuddin S]]
-	~~[[Category: Bacterial protein]]~~	+
-	~~[[Category: Binding site]]~~	+
-	~~[[Category: Copper]]~~	+
-	~~[[Category: Methylocystaceae]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxygenase]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 07:54, 17 April 2019

2019-04-17T07:54:39Z

←Older revision		Revision as of 07:54, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)==		==Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)==
-	<StructureSection load='4phz' size='340' side='right' caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='4phz' size='340' side='right'caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylocystis_sp._atcc_49242 Methylocystis sp. atcc 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylocystis_sp._atcc_49242 Methylocystis sp. atcc 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://pdbe.org/4phz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://pdbe.org/4phz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4phz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Methylocystis sp. atcc 49242]]		[[Category: Methylocystis sp. atcc 49242]]
	[[Category: Rosenzweig, A C]]		[[Category: Rosenzweig, A C]]

OCA at 18:54, 10 May 2016

2016-05-10T18:54:58Z

←Older revision		Revision as of 18:54, 10 May 2016
Line 1:		Line 1:
		+
	==Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)==		==Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)==
	<StructureSection load='4phz' size='340' side='right' caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4phz' size='340' side='right' caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://pdbe.org/4phz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4phz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Methane monooxygenase\|Methane monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:32, 20 January 2015

2015-01-20T09:32:13Z

←Older revision		Revision as of 09:32, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylocystis_sp._atcc_49242 Methylocystis sp. atcc 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylocystis_sp._atcc_49242 Methylocystis sp. atcc 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Methylocystis sp. atcc 49242]]		[[Category: Methylocystis sp. atcc 49242]]
-	[[Category: Rosenzweig, A C.]]	+	[[Category: Rosenzweig, A C]]
-	[[Category: Sirajuddin, S.]]	+	[[Category: Sirajuddin, S]]
	[[Category: Bacterial protein]]		[[Category: Bacterial protein]]
	[[Category: Binding site]]		[[Category: Binding site]]

OCA at 06:21, 9 July 2014

2014-07-09T06:21:18Z

←Older revision		Revision as of 06:21, 9 July 2014
Line 9:		Line 9:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Particulate methane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. Zinc is a known inhibitor of pMMO, but the details of zinc binding and the mechanism of inhibition are not understood. Metal binding and activity assays on membrane-bound pMMO from Methylococcus capsulatus (Bath) reveal that zinc inhibits pMMO at two sites that are distinct from the copper active site. The 2.6 A resolution crystal structure of Methylocystis species strain Rockwell pMMO reveals two previously undetected bound lipids, and metal soaking experiments identify likely locations for the two zinc inhibition sites. The first is the crystallographic zinc site in the pmoC subunit, and zinc binding here leads to ordering of 10 previously unobserved residues. A second zinc site is present on the cytoplasmic side of the pmoC subunit. Parallels between these results and zinc inhibition studies of several respiratory complexes suggest that zinc might inhibit proton transfer in pMMO.
		+
		+	Effects of Zinc on Particulate Methane Monooxygenase Activity and Structure.,Sirajuddin S, Barupala D, Helling S, Marcus K, Stemmler TL, Rosenzweig AC J Biol Chem. 2014 Jun 18. pii: jbc.M114.581363. PMID:24942740<ref>PMID:24942740</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:36, 25 June 2014

2014-06-25T06:36:17Z

←Older revision		Revision as of 06:36, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)==
-		+	<StructureSection load='4phz' size='340' side='right' caption='[[4phz]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~The entry~~ 4phz is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4phz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylocystis_sp._atcc_49242 Methylocystis sp. atcc 49242]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PHZ FirstGlance]. <br>
-	~~Authors~~: ~~Sirajuddin~~, S., ~~Rosenzweig~~, A.C.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	~~Description~~: ~~Crystal structure of particulate methane monooxygenase from~~ Methylocystis sp. ~~ATCC~~ 49242 ~~(Rockwell)~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pi0\|4pi0]], [[4pi2\|4pi2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methane_monooxygenase_(particulate) Methane monooxygenase (particulate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.3 1.14.18.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4phz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4phz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4phz RCSB], [http://www.ebi.ac.uk/pdbsum/4phz PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Methylocystis sp. atcc 49242]]
		+	[[Category: Rosenzweig, A C.]]
		+	[[Category: Sirajuddin, S.]]
		+	[[Category: Bacterial protein]]
		+	[[Category: Binding site]]
		+	[[Category: Copper]]
		+	[[Category: Methylocystaceae]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxygenase]]
		+	[[Category: Protein binding]]
		+	[[Category: Zinc]]

OCA at 08:11, 28 May 2014

2014-05-28T08:11:17Z

←Older revision		Revision as of 08:11, 28 May 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4phz is ON HOLD	+	The entry 4phz is ON HOLD until Paper Publication

	Authors: Sirajuddin, S., Rosenzweig, A.C.		Authors: Sirajuddin, S., Rosenzweig, A.C.

	Description: Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)		Description: Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)

OCA: Protected "4phz" [edit=sysop:move=sysop]

2014-05-14T07:08:35Z

Protected "4phz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:08, 14 May 2014

OCA: New page: '''Unreleased structure''' The entry 4phz is ON HOLD Authors: Sirajuddin, S., Rosenzweig, A.C. Description: Crystal structure of particulate methane monooxygenase from Methylocystis sp...

2014-05-14T07:08:35Z

New page: '''Unreleased structure''' The entry 4phz is ON HOLD Authors: Sirajuddin, S., Rosenzweig, A.C. Description: Crystal structure of particulate methane monooxygenase from Methylocystis sp...

New page

'''Unreleased structure'''

The entry 4phz is ON HOLD

Authors: Sirajuddin, S., Rosenzweig, A.C.

Description: Crystal structure of particulate methane monooxygenase from Methylocystis sp. ATCC 49242 (Rockwell)