4pl4 - Revision history

OCA at 07:17, 27 September 2023

2023-09-27T07:17:47Z

←Older revision		Revision as of 07:17, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [https://pdbe.org/4pl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [https://pdbe.org/4pl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:16, 8 February 2023

2023-02-08T07:16:50Z

←Older revision		Revision as of 07:16, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pl4' size='340' side='right'caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4pl4' size='340' side='right'caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [https://pdbe.org/4pl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ern1, Ire1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [~~http~~://pdbe.org/4pl4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>	+	[https://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Al-awar, R]]	+	[[Category: Al-awar R]]
-	[[Category: Chiovitti, D]]	+	[[Category: Chiovitti D]]
-	[[Category: Duffy, N]]	+	[[Category: Duffy N]]
-	[[Category: Patterson~~, J B~~]]	+	[[Category: Patterson JB]]
-	[[Category: Sanches, M]]	+	[[Category: Sanches M]]
-	[[Category: Sicheri, F]]	+	[[Category: Sicheri F]]
-	[[Category: Talukdar, M]]	+	[[Category: Talukdar M]]
-	[[Category: Thevakumaran, N]]	+	[[Category: Thevakumaran N]]
-	~~[[Category: Endoribonuclease]]~~	+
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Schiff base]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Unfolded protein response~~]]	+

OCA at 07:47, 8 January 2020

2020-01-08T07:47:15Z

←Older revision		Revision as of 07:47, 8 January 2020
Line 1:		Line 1:

	==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==		==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==
-	<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4pl4' size='340' side='right'caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4pl4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pl4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ire1\|Ire1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Al-awar, R]]		[[Category: Al-awar, R]]

OCA at 08:42, 22 November 2017

2017-11-22T08:42:24Z

←Older revision		Revision as of 08:42, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ern1, Ire1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://pdbe.org/4pl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://pdbe.org/4pl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Al-awar, R]]		[[Category: Al-awar, R]]
	[[Category: Chiovitti, D]]		[[Category: Chiovitti, D]]
Line 32:		Line 34:
	[[Category: Thevakumaran, N]]		[[Category: Thevakumaran, N]]
	[[Category: Endoribonuclease]]		[[Category: Endoribonuclease]]
		+	[[Category: Hydrolase-inhibitor complex]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
		+	[[Category: Transferase]]
	[[Category: Unfolded protein response]]		[[Category: Unfolded protein response]]

OCA at 18:10, 4 August 2016

2016-08-04T18:10:46Z

←Older revision		Revision as of 18:10, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==		==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==
	<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://pdbe.org/4pl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pl4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:46, 25 December 2014

2014-12-25T11:46:56Z

←Older revision		Revision as of 11:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Al-awar, R.]]	+	[[Category: Al-awar, R]]
-	[[Category: Chiovitti, D.]]	+	[[Category: Chiovitti, D]]
-	[[Category: Duffy, N.]]	+	[[Category: Duffy, N]]
-	[[Category: Patterson, J B.]]	+	[[Category: Patterson, J B]]
-	[[Category: Sanches, M.]]	+	[[Category: Sanches, M]]
-	[[Category: Sicheri, F.]]	+	[[Category: Sicheri, F]]
-	[[Category: Talukdar, M.]]	+	[[Category: Talukdar, M]]
-	[[Category: Thevakumaran, N.]]	+	[[Category: Thevakumaran, N]]
	[[Category: Endoribonuclease]]		[[Category: Endoribonuclease]]
	[[Category: Inhibitor complex]]		[[Category: Inhibitor complex]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
	[[Category: Unfolded protein response]]		[[Category: Unfolded protein response]]

OCA at 07:38, 10 September 2014

2014-09-10T07:38:25Z

←Older revision		Revision as of 07:38, 10 September 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1alpha is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish ER homeostasis. Aromatic ring systems containing hydroxy-aldehyde moieties, termed hydroxy-aryl-aldehydes (HAA), selectively inhibit IRE1alpha RNase and thus represent a novel chemical series for therapeutic development. We solved crystal structures of murine IRE1alpha in complex with three HAA inhibitors. HAA inhibitors engage a shallow pocket at the RNase-active site through pi-stacking interactions with His910 and Phe889, an essential Schiff base with Lys907 and a hydrogen bond with Tyr892. Structure-activity studies and mutational analysis of contact residues define the optimal chemical space of inhibitors and validate the inhibitor-binding site. These studies lay the foundation for understanding both the biochemical and cellular functions of IRE1alpha using small molecule inhibitors and suggest new avenues for inhibitor design.
		+
		+	Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.,Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-Awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. PMID:25164867<ref>PMID:25164867</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:10, 4 September 2014

2014-09-04T06:10:56Z

←Older revision		Revision as of 06:10, 4 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of murine IRE1 in complex with OICR464 inhibitor==
-		+	<StructureSection load='4pl4' size='340' side='right' caption='[[4pl4]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~The entry~~ 4pl4 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL4 FirstGlance]. <br>
-	~~Authors~~: ~~Sanches~~, M., ~~Duffy~~, N., ~~Talukdar~~, M., ~~Thevakumaran~~, N., ~~Chiovitti~~, D., Al-awar, R., Patterson, J.B., Sicheri, F.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31K:2-METHOXY-6-METHYL-4-(4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)PHENOL'>31K</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pl3\|4pl3]], [[4pl5\|4pl5]]</td></tr>
-	~~Description~~:	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl4 PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Al-awar, R.]]
		+	[[Category: Chiovitti, D.]]
		+	[[Category: Duffy, N.]]
		+	[[Category: Patterson, J B.]]
		+	[[Category: Sanches, M.]]
		+	[[Category: Sicheri, F.]]
		+	[[Category: Talukdar, M.]]
		+	[[Category: Thevakumaran, N.]]
		+	[[Category: Endoribonuclease]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Schiff base]]
		+	[[Category: Unfolded protein response]]

OCA at 07:55, 11 June 2014

2014-06-11T07:55:07Z

←Older revision		Revision as of 07:55, 11 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pl4 is ON HOLD	+	The entry 4pl4 is ON HOLD until Paper Publication

	Authors: Sanches, M., Duffy, N., Talukdar, M., Thevakumaran, N., Chiovitti, D., Al-awar, R., Patterson, J.B., Sicheri, F.		Authors: Sanches, M., Duffy, N., Talukdar, M., Thevakumaran, N., Chiovitti, D., Al-awar, R., Patterson, J.B., Sicheri, F.

	Description:		Description:

OCA: Protected "4pl4" [edit=sysop:move=sysop]

2014-05-21T08:08:49Z

Protected "4pl4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:08, 21 May 2014