4pla - Revision history

OCA at 00:45, 28 December 2023

2023-12-28T00:45:19Z

←Older revision		Revision as of 00:45, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.771Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [https://pdbe.org/4pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [https://www.ebi.ac.uk/pdbsum/4pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [https://pdbe.org/4pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [https://www.ebi.ac.uk/pdbsum/4pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:17, 8 February 2023

2023-02-08T07:17:05Z

←Older revision		Revision as of 07:17, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pla' size='340' side='right'caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>		<StructureSection load='4pla' size='340' side='right'caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI4K2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [https://pdbe.org/4pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [https://www.ebi.ac.uk/pdbsum/4pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [~~http~~://pdbe.org/4pla PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pla PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.	+	[https://www.uniprot.org/uniprot/D9IEF7_BPT4 D9IEF7_BPT4] [https://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4pla" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pla" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphatidylinositol 4-kinase\|Phosphatidylinositol 4-kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia virus T4]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baumlova, A]]	+	[[Category: Baumlova A]]
-	[[Category: Boura, E]]	+	[[Category: Boura E]]
-	[[Category: Chalupska, D]]	+	[[Category: Chalupska D]]
-	~~[[Category: 4-kinase]]~~	+
-	~~[[Category: Atp]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipid]]~~	+
-	~~[[Category: Phosphatidyl inositol]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:34, 17 April 2019

2019-04-17T07:34:41Z

←Older revision		Revision as of 07:34, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==		==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==
-	<StructureSection load='4pla' size='340' side='right' caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>	+	<StructureSection load='4pla' size='340' side='right'caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI4K2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://pdbe.org/4pla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://pdbe.org/4pla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baumlova, A]]		[[Category: Baumlova, A]]
	[[Category: Boura, E]]		[[Category: Boura, E]]

OCA at 11:44, 11 August 2016

2016-08-11T11:44:11Z

←Older revision		Revision as of 11:44, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==		==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==
	<StructureSection load='4pla' size='340' side='right' caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>		<StructureSection load='4pla' size='340' side='right' caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://pdbe.org/4pla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pla ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pla" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:14, 25 December 2014

2014-12-25T01:14:18Z

←Older revision		Revision as of 01:14, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baumlova, A.]]	+	[[Category: Baumlova, A]]
-	[[Category: Boura, E.]]	+	[[Category: Boura, E]]
-	[[Category: Chalupska, D.]]	+	[[Category: Chalupska, D]]
	[[Category: 4-kinase]]		[[Category: 4-kinase]]
	[[Category: Atp]]		[[Category: Atp]]

OCA at 08:34, 20 October 2014

2014-10-20T08:34:06Z

←Older revision		Revision as of 08:34, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:52, 10 September 2014

2014-09-10T09:52:43Z

←Older revision		Revision as of 09:52, 10 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP==
		+	<StructureSection load='4pla' size='340' side='right' caption='[[4pla]], [[Resolution\|resolution]] 2.77Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phosphoinositides are a class of phospholipids generated by the action of phosphoinositide kinases with key regulatory functions in eukaryotic cells. Here, we present the atomic structure of phosphatidylinositol 4-kinase type IIalpha (PI4K IIalpha), in complex with ATP solved by X-ray crystallography at 2.8 A resolution. The structure revealed a non-typical kinase fold that could be divided into N- and C-lobes with the ATP binding groove located in between. Surprisingly, a second ATP was found in a lateral hydrophobic pocket of the C-lobe. Molecular simulations and mutagenesis analysis revealed the membrane binding mode and the putative function of the hydrophobic pocket. Taken together, our results suggest a mechanism of PI4K IIalpha recruitment, regulation, and function at the membrane.

-	The ~~entry 4pla is ON HOLD until Paper Publication~~	+	The crystal structure of the phosphatidylinositol 4-kinase IIalpha,Baumlova A, Chalupska D, Rozycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E EMBO Rep. 2014 Aug 28. pii: e201438841. PMID:25168678<ref>PMID:25168678</ref>

-	~~Authors~~: Baumlova, A., Chalupska, D.~~, Boura, E.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of phosphatidyl inositol~~ 4-kinase ~~II alpha in complex with ATP~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Baumlova, A.]]
		+	[[Category: Boura, E.]]
		+	[[Category: Chalupska, D.]]
		+	[[Category: 4-kinase]]
		+	[[Category: Atp]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lipid]]
		+	[[Category: Phosphatidyl inositol]]
		+	[[Category: Transferase]]

OCA: Protected "4pla" [edit=sysop:move=sysop]

2014-05-28T08:15:10Z

Protected "4pla" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 28 May 2014

OCA: New page: '''Unreleased structure''' The entry 4pla is ON HOLD until Paper Publication Authors: Baumlova, A., Chalupska, D., Boura, E. Description: Crystal structure of phosphatidyl inositol 4-k...

2014-05-28T08:15:08Z

New page: '''Unreleased structure''' The entry 4pla is ON HOLD until Paper Publication Authors: Baumlova, A., Chalupska, D., Boura, E. Description: Crystal structure of phosphatidyl inositol 4-k...

New page

'''Unreleased structure'''

The entry 4pla is ON HOLD until Paper Publication

Authors: Baumlova, A., Chalupska, D., Boura, E.

Description: Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP