4pnd - Revision history

OCA at 07:20, 8 February 2023

2023-02-08T07:20:12Z

←Older revision		Revision as of 07:20, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pnd' size='340' side='right'caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4pnd' size='340' side='right'caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PND FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PND FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [~~http~~://pdbe.org/4pnd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pnd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [https://pdbe.org/4pnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [https://www.ebi.ac.uk/pdbsum/4pnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brady, R L~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Burton, A J~~]]	+	[[Category: Brady RL]]
-	[[Category: ~~Thomson, A R~~]]	+	[[Category: Burton AJ]]
-	[[Category: ~~Wood, C W~~]]	+	[[Category: Thomson AR]]
-	[[Category: ~~Woolfson, D N~~]]	+	[[Category: Wood CW]]
-	[[Category: ~~Alpha-helical barrel]]~~	+	[[Category: Woolfson DN]]
-	~~[[Category: Artificially designed - often synthetic]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Protein design~~]]	+

OCA at 07:17, 10 July 2019

2019-07-10T07:17:01Z

←Older revision		Revision as of 07:17, 10 July 2019
Line 1:		Line 1:

	==A de novo designed pentameric coiled coil CC-Pent_Variant==		==A de novo designed pentameric coiled coil CC-Pent_Variant==
-	<StructureSection load='4pnd' size='340' side='right' caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4pnd' size='340' side='right'caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PND FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Burton, A J]]		[[Category: Burton, A J]]

OCA at 03:25, 5 August 2016

2016-08-05T03:25:16Z

←Older revision		Revision as of 03:25, 5 August 2016
Line 1:		Line 1:
		+
	==A de novo designed pentameric coiled coil CC-Pent_Variant==		==A de novo designed pentameric coiled coil CC-Pent_Variant==
	<StructureSection load='4pnd' size='340' side='right' caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4pnd' size='340' side='right' caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PND FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [http://www.ebi.ac.uk/pdbsum/4pnd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [http://pdbe.org/4pnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [http://www.ebi.ac.uk/pdbsum/4pnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pnd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:09, 17 December 2014

2014-12-17T09:09:21Z

←Older revision		Revision as of 09:09, 17 December 2014
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Burton, A J.]]	+	[[Category: Burton, A J]]
-	[[Category: Thomson, A R.]]	+	[[Category: Thomson, A R]]
-	[[Category: Wood, C W.]]	+	[[Category: Wood, C W]]
-	[[Category: Woolfson, D N.]]	+	[[Category: Woolfson, D N]]
	[[Category: Alpha-helical barrel]]		[[Category: Alpha-helical barrel]]
	[[Category: Artificially designed - often synthetic]]		[[Category: Artificially designed - often synthetic]]

OCA at 07:02, 5 November 2014

2014-11-05T07:02:37Z

←Older revision		Revision as of 07:02, 5 November 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [http://www.ebi.ac.uk/pdbsum/4pnd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [http://www.ebi.ac.uk/pdbsum/4pnd PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design of protein sequences that fold into prescribed de novo structures is challenging. General solutions to this problem require geometric descriptions of protein folds and methods to fit sequences to these. The alpha-helical coiled coils present a promising class of protein for this and offer considerable scope for exploring hitherto unseen structures. For alpha-helical barrels, which have more than four helices and accessible central channels, many of the possible structures remain unobserved. Here, we combine geometrical considerations, knowledge-based scoring, and atomistic modeling to facilitate the design of new channel-containing alpha-helical barrels. X-ray crystal structures of the resulting designs match predicted in silico models. Furthermore, the observed channels are chemically defined and have diameters related to oligomer state, which present routes to design protein function.
		+
		+	Computational design of water-soluble alpha-helical barrels.,Thomson AR, Wood CW, Burton AJ, Bartlett GJ, Sessions RB, Brady RL, Woolfson DN Science. 2014 Oct 24;346(6208):485-8. doi: 10.1126/science.1257452. PMID:25342807<ref>PMID:25342807</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:42, 22 October 2014

2014-10-22T11:42:44Z

←Older revision		Revision as of 11:42, 22 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==A de novo designed pentameric coiled coil CC-Pent_Variant==
-		+	<StructureSection load='4pnd' size='340' side='right' caption='[[4pnd]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~The entry~~ 4pnd is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pnd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PND FirstGlance]. <br>
-	~~Authors~~: ~~Wood~~, C.W., Burton, A.J., Thomson, A.R., ~~Brady, R~~.~~L.,~~ Woolfson, D.N.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnd RCSB], [http://www.ebi.ac.uk/pdbsum/4pnd PDBsum]</span></td></tr>
-	~~Description~~: ~~A de novo~~ designed ~~pentameric coiled coil CC~~-~~Pent_Variant~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brady, R L.]]
		+	[[Category: Burton, A J.]]
		+	[[Category: Thomson, A R.]]
		+	[[Category: Wood, C W.]]
		+	[[Category: Woolfson, D N.]]
		+	[[Category: Alpha-helical barrel]]
		+	[[Category: Artificially designed - often synthetic]]
		+	[[Category: Coiled coil]]
		+	[[Category: De novo protein]]
		+	[[Category: Protein design]]

OCA: Protected "4pnd" [edit=sysop:move=sysop]

2014-06-04T04:56:15Z

Protected "4pnd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4pnd is ON HOLD until Paper Publication Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N. Description: A de novo design...

2014-06-04T04:56:14Z

New page: '''Unreleased structure''' The entry 4pnd is ON HOLD until Paper Publication Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N. Description: A de novo design...

New page

'''Unreleased structure'''

The entry 4pnd is ON HOLD until Paper Publication

Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N.

Description: A de novo designed pentameric coiled coil CC-Pent_Variant