4pnf - Revision history

OCA at 00:45, 28 December 2023

2023-12-28T00:45:48Z

←Older revision		Revision as of 00:45, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [https://pdbe.org/4pnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [https://www.ebi.ac.uk/pdbsum/4pnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [https://pdbe.org/4pnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [https://www.ebi.ac.uk/pdbsum/4pnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnf ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4pnf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pnf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:20, 8 February 2023

2023-02-08T07:20:19Z

←Older revision		Revision as of 07:20, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pnf' size='340' side='right'caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4pnf' size='340' side='right'caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PNF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GstE6, CG17530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [https://pdbe.org/4pnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [https://www.ebi.ac.uk/pdbsum/4pnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [~~http~~://pdbe.org/4pnf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pnf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7JZM3_DROME Q7JZM3_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Atkins~~, W M]]~~	+	[[Category: Atkins WM]]
-	~~[[Category: Mannervik, B]]~~	+	[[Category: Le Trong I]]
-	~~[[Category: Scian, M]]~~	+	[[Category: Mannervik B]]
-	~~[[Category: Stenkamp, R E~~]]	+	[[Category: Scian M]]
-	[[Category: Trong, I Le]]	+	[[Category: Stenkamp RE]]
-	[[Category: ~~Glutathione complex~~]]	+
-	[[Category: ~~Glutathione s-transferase~~]]	+
-	[[Category: ~~Isozyme]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:41, 1 January 2020

2020-01-01T08:41:01Z

←Older revision		Revision as of 08:41, 1 January 2020
Line 1:		Line 1:

	==Glutathione S-Transferase from Drosophila melanogaster - isozyme E6==		==Glutathione S-Transferase from Drosophila melanogaster - isozyme E6==
-	<StructureSection load='4pnf' size='340' side='right' caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='4pnf' size='340' side='right'caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Atkins, W M]]		[[Category: Atkins, W M]]
	[[Category: Mannervik, B]]		[[Category: Mannervik, B]]

OCA at 12:02, 6 November 2017

2017-11-06T12:02:33Z

←Older revision		Revision as of 12:02, 6 November 2017
Line 1:		Line 1:
		+
	==Glutathione S-Transferase from Drosophila melanogaster - isozyme E6==		==Glutathione S-Transferase from Drosophila melanogaster - isozyme E6==
	<StructureSection load='4pnf' size='340' side='right' caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4pnf' size='340' side='right' caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [http://pdbe.org/4pnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [http://www.ebi.ac.uk/pdbsum/4pnf PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GstE6, CG17530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [http://pdbe.org/4pnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [http://www.ebi.ac.uk/pdbsum/4pnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Atkins, W M]]		[[Category: Atkins, W M]]
	[[Category: Mannervik, B]]		[[Category: Mannervik, B]]

OCA at 07:00, 16 December 2015

2015-12-16T07:00:38Z

←Older revision		Revision as of 07:00, 16 December 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [http://www.ebi.ac.uk/pdbsum/4pnf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [http://pdbe.org/4pnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [http://www.ebi.ac.uk/pdbsum/4pnf PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic glutathione transferases (GSTs) comprise a large family of enzymes with canonical structures that diverge functionally and structurally among mammals, invertebrates and plants. Whereas mammalian GSTs have been characterized extensively with regard to their structure and function, invertebrate GSTs remain relatively unstudied. The invertebrate GSTs do, however, represent potentially important drug targets for infectious diseases and agricultural applications. In addition, it is essential to fully understand the structure and function of invertebrate GSTs, which play important roles in basic biological processes. Invertebrates harbor delta- and epsilon-class GSTs, which are not found in other organisms. Drosophila melanogaster GSTs (DmGSTs) are likely to contribute to detoxication or antioxidative stress during development, but they have not been fully characterized. Here, the structures of two epsilon-class GSTs from Drosophila, DmGSTE6 and DmGSTE7, are reported at 2.1 and 1.5 A resolution, respectively, and are compared with other GSTs to identify structural features that might correlate with their biological functions. The structures of DmGSTE6 and DmGSTE7 are remarkably similar; the structures do not reveal obvious sources of the minor functional differences that have been observed. The main structural difference between the epsilon- and delta-class GSTs is the longer helix (A8) at the C-termini of the epsilon-class enzymes.
		+
		+	Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.,Scian M, Le Trong I, Mazari AM, Mannervik B, Atkins WM, Stenkamp RE Acta Crystallogr D Biol Crystallogr. 2015 Oct 1;71(Pt 10):2089-98. doi:, 10.1107/S1399004715013929. Epub 2015 Sep 26. PMID:26457432<ref>PMID:26457432</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4pnf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:56, 27 May 2015

2015-05-27T15:56:27Z

←Older revision		Revision as of 15:56, 27 May 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Glutathione S-Transferase from Drosophila melanogaster - isozyme E6==
-		+	<StructureSection load='4pnf' size='340' side='right' caption='[[4pnf]], [[Resolution\|resolution]] 2.11Å' scene=''>
-	~~The entry~~ 4pnf is ~~ON HOLD until May 27 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pnf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNF FirstGlance]. <br>
-	~~Authors~~: ~~Scian, M~~.~~, Le Trong, I~~.~~, Mannervik, B~~.~~, Atkins, W~~.M.~~, Stenkamp, R~~.E.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnf RCSB], [http://www.ebi.ac.uk/pdbsum/4pnf PDBsum]</span></td></tr>
-	~~Description: Glutathione S-Transferase from Drosophila melanogaster~~ -~~isozyme E6~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[~~[Category~~: ~~Stenkamp, R~~.E]]	+	</StructureSection>
-	[~~[Category~~: ~~Atkins, W~~.M]]	+	[[Category: Atkins, W M]]
-	[~~[Category~~: ~~Scian~~, M]]	+
-	[[Category: ~~Le Trong~~, I]]	+
	[[Category: Mannervik, B]]		[[Category: Mannervik, B]]
		+	[[Category: Scian, M]]
		+	[[Category: Stenkamp, R E]]
		+	[[Category: Trong, I Le]]
		+	[[Category: Glutathione complex]]
		+	[[Category: Glutathione s-transferase]]
		+	[[Category: Isozyme]]
		+	[[Category: Transferase]]

OCA at 08:18, 6 May 2015

2015-05-06T08:18:37Z

←Older revision		Revision as of 08:18, 6 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pnf is ON HOLD until ~~Paper Publication~~	+	The entry 4pnf is ON HOLD until May 27 2016

	Authors: Scian, M., Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.		Authors: Scian, M., Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.

OCA at 15:08, 24 December 2014

2014-12-24T15:08:13Z

←Older revision		Revision as of 15:08, 24 December 2014
Line 6:		Line 6:

	Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6		Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6
		+	[[Category: Unreleased Structures]]
		+	[[Category: Stenkamp, R.E]]
		+	[[Category: Atkins, W.M]]
		+	[[Category: Scian, M]]
		+	[[Category: Le Trong, I]]
		+	[[Category: Mannervik, B]]

OCA at 01:00, 7 August 2014

2014-08-07T01:00:17Z

←Older revision		Revision as of 01:00, 7 August 2014
Line 3:		Line 3:
	The entry 4pnf is ON HOLD until Paper Publication		The entry 4pnf is ON HOLD until Paper Publication

-	Authors: Scian, M, Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.	+	Authors: Scian, M., Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.

	Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6		Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6

OCA at 09:41, 16 July 2014

2014-07-16T09:41:34Z

←Older revision		Revision as of 09:41, 16 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pnf is ON HOLD	+	The entry 4pnf is ON HOLD until Paper Publication

	Authors: Scian, M, Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.		Authors: Scian, M, Le Trong, I., Mannervik, B., Atkins, W.M., Stenkamp, R.E.

	Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6		Description: Glutathione S-Transferase from Drosophila melanogaster -isozyme E6