4puv - Revision history

OCA at 15:01, 8 November 2023

2023-11-08T15:01:20Z

←Older revision		Revision as of 15:01, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [https://pdbe.org/4puv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [https://www.ebi.ac.uk/pdbsum/4puv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [https://pdbe.org/4puv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [https://www.ebi.ac.uk/pdbsum/4puv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:32, 8 February 2023

2023-02-08T07:32:21Z

←Older revision		Revision as of 07:32, 8 February 2023
Line 1:		Line 1:

	==URATE OXIDASE DI-AZIDE complex==		==URATE OXIDASE DI-AZIDE complex==
-	<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4puv' size='340' side='right'caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aspfl Aspfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PUV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PUV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~AZI~~:~~AZIDE~~+~~ION~~'>~~AZI~~</scene>, <scene name='pdbligand=NA:~~SODIUM~~+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~ACE~~:~~ACETYL~~+~~GROUP~~'>~~ACE~~</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [https://pdbe.org/4puv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [https://www.ebi.ac.uk/pdbsum/4puv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [~~http~~://pdbe.org/4puv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4puv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4puv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4puv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urate oxidase 3D structures\|Urate oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspfl~~]]	+	[[Category: Aspergillus flavus]]
-	[[Category: ~~Factor independent urate hydroxylase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Prange, T]]~~	+	[[Category: Colloc'h N]]
-	~~[[Category: H,~~ N ~~Colloc~~]]	+	[[Category: Prange T]]
-	[[Category: ~~Azide]]~~	+
-	~~[[Category: Degradation mechanism]]~~	+
-	~~[[Category: Heterotetramer]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxygen binding]]~~	+
-	~~[[Category: Peroxisome]]~~	+
-	~~[[Category: Purine metabolism~~]]	+

OCA at 07:03, 28 February 2018

2018-02-28T07:03:38Z

←Older revision		Revision as of 07:03, 28 February 2018
Line 3:		Line 3:
	<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [http://pdbe.org/4puv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [http://www.ebi.ac.uk/pdbsum/4puv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [http://pdbe.org/4puv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [http://www.ebi.ac.uk/pdbsum/4puv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4puv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4puv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aspfl]]
	[[Category: Factor independent urate hydroxylase]]		[[Category: Factor independent urate hydroxylase]]
		+	[[Category: Prange, T]]
	[[Category: H, N Colloc]]		[[Category: H, N Colloc]]
-	[[Category: Prange, T]]
	[[Category: Azide]]		[[Category: Azide]]
	[[Category: Degradation mechanism]]		[[Category: Degradation mechanism]]

OCA at 09:25, 2 January 2017

2017-01-02T09:25:10Z

←Older revision		Revision as of 09:25, 2 January 2017
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ACE~~:~~ACETYL~~+~~GROUP~~'>~~ACE~~</scene>, <scene name='pdbligand=~~AZI~~:~~AZIDE~~+ION'>~~AZI~~</scene>, <scene name='pdbligand=NA:~~SODIUM~~+~~ION~~'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>

OCA at 09:09, 4 August 2016

2016-08-04T09:09:13Z

←Older revision		Revision as of 09:09, 4 August 2016
Line 1:		Line 1:
		+
	==URATE OXIDASE DI-AZIDE complex==		==URATE OXIDASE DI-AZIDE complex==
	<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [http://www.ebi.ac.uk/pdbsum/4puv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [http://pdbe.org/4puv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [http://www.ebi.ac.uk/pdbsum/4puv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4puv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4puv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:03, 24 December 2014

2014-12-24T08:03:11Z

←Older revision		Revision as of 08:03, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==URATE OXIDASE DI-AZIDE complex==
		+	<StructureSection load='4puv' size='340' side='right' caption='[[4puv]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4puv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pr8\|4pr8]], [[4poe\|4poe]], [[4oqc\|4oqc]], [[3p9f\|3p9f]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4puv RCSB], [http://www.ebi.ac.uk/pdbsum/4puv PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The inhibition of urate oxidase (UOX) by azide was investigated by X-ray diffraction techniques and compared with cyanide inhibition. Two well characterized sites for reagents are present in the enzyme: the dioxygen site and the substrate-binding site. To examine the selectivity of these sites towards azide inhibition, several crystallization conditions were developed. UOX was co-crystallized with azide (N3) in the presence or absence of either uric acid (UA, the natural substrate) or 8-azaxanthine (8AZA, a competitive inhibitor). In a second set of experiments, previously grown orthorhombic crystals of the UOX-UA or UOX-8AZA complexes were soaked in sodium azide solutions. In a third set of experiments, orthorhombic crystals of UOX with the exchangeable ligand 8-nitroxanthine (8NXN) were soaked in a solution containing uric acid and azide simultaneously (competitive soaking). In all assays, the soaking periods were either short (a few hours) or long (one or two months). These different experimental conditions showed that one or other of the sites, or the two sites together, could be inhibited. This also demonstrated that azide not only competes with dioxygen as cyanide does but also competes with the substrate for its enzymatic site. A model in agreement with experimental data would be an azide in equilibrium between two sites, kinetically in favour of the dioxygen site and thermodynamically in favour of the substrate-binding site.

-	~~The entry 4puv is ON HOLD until Paper Publication~~	+	Azide inhibition of urate oxidase.,Gabison L, Colloc'h N, Prange T Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):896-902. doi:, 10.1107/S2053230X14011753. Epub 2014 Jun 18. PMID:25005084<ref>PMID:25005084</ref>

-	~~Authors~~: ~~Colloc'~~H, N., Prange, T.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~URATE OXIDASE DI-AZIDE complex~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Factor independent urate hydroxylase]]
		+	[[Category: H, N Colloc]]
		+	[[Category: Prange, T]]
		+	[[Category: Azide]]
		+	[[Category: Degradation mechanism]]
		+	[[Category: Heterotetramer]]
		+	[[Category: Inhibition]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxygen binding]]
		+	[[Category: Peroxisome]]
		+	[[Category: Purine metabolism]]

OCA at 08:33, 2 April 2014

2014-04-02T08:33:37Z

←Older revision		Revision as of 08:33, 2 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4puv is ON HOLD	+	The entry 4puv is ON HOLD until Paper Publication

	Authors: Colloc'H, N., Prange, T.		Authors: Colloc'H, N., Prange, T.

-	Description: URATE OXIDASE DI-AZIDE ~~COMPLEX~~	+	Description: URATE OXIDASE DI-AZIDE complex

OCA: Protected "4puv" [edit=sysop:move=sysop]

2014-03-26T08:52:01Z

Protected "4puv" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:52, 26 March 2014

OCA: New page: '''Unreleased structure''' The entry 4puv is ON HOLD Authors: Colloc'H, N., Prange, T. Description: URATE OXIDASE DI-AZIDE COMPLEX

2014-03-26T08:52:00Z

New page: '''Unreleased structure''' The entry 4puv is ON HOLD Authors: Colloc'H, N., Prange, T. Description: URATE OXIDASE DI-AZIDE COMPLEX

New page

'''Unreleased structure'''

The entry 4puv is ON HOLD

Authors: Colloc'H, N., Prange, T.

Description: URATE OXIDASE DI-AZIDE COMPLEX