4pvo - Revision history

OCA at 15:01, 8 November 2023

2023-11-08T15:01:57Z

←Older revision		Revision as of 15:01, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [https://pdbe.org/4pvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [https://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [https://pdbe.org/4pvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [https://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 8 February 2023

2023-02-08T07:33:13Z

←Older revision		Revision as of 07:33, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pvo' size='340' side='right'caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4pvo' size='340' side='right'caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [https://pdbe.org/4pvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [https://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla-VIM-2, blasVIM-2, blaVIM-2, blaVIM2, VIM-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [~~http~~://pdbe.org/4pvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9K2N0_PSEAI Q9K2N0_PSEAI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Aik, W S~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Brem, J~~]]	+	[[Category: Aik WS]]
-	[[Category: ~~McDonough, M A]]~~	+	[[Category: Brem J]]
-	~~[[Category: Schofield, C~~ J]]	+	[[Category: McDonough MA]]
-	[[Category: ~~Alpha-beta/beta-alpha fold~~]]	+	[[Category: Schofield CJ]]
-	[[Category: ~~Beta-lactamase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 08:11, 17 April 2019

2019-04-17T08:11:16Z

←Older revision		Revision as of 08:11, 17 April 2019
Line 1:		Line 1:

	==Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F==		==Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F==
-	<StructureSection load='4pvo' size='340' side='right' caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='4pvo' size='340' side='right'caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla-VIM-2, blasVIM-2, blaVIM-2, blaVIM2, VIM-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://pdbe.org/4pvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://pdbe.org/4pvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aik, W S]]		[[Category: Aik, W S]]
	[[Category: Brem, J]]		[[Category: Brem, J]]

OCA at 17:12, 4 January 2017

2017-01-04T17:12:36Z

←Older revision		Revision as of 17:12, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F==		==Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F==
	<StructureSection load='4pvo' size='340' side='right' caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='4pvo' size='340' side='right' caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://pdbe.org/4pvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pvo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:14, 25 February 2015

2015-02-25T08:14:23Z

←Older revision		Revision as of 08:14, 25 February 2015
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The use of beta-lactam antibiotics is compromised by resistance, which is provided by beta-lactamases belonging to both metallo (MBL)- and serine (SBL)-beta-lactamase subfamilies. The rhodanines are one of very few compound classes that inhibit penicillin-binding proteins (PBPs), SBLs and, as recently reported, MBLs. Here, we describe crystallographic analyses of the mechanism of inhibition of the clinically relevant VIM-2 MBL by a rhodanine, which reveal that the rhodanine ring undergoes hydrolysis to give a thioenolate. The thioenolate is found to bind via di-zinc chelation, mimicking the binding of intermediates in beta-lactam hydrolysis. Crystallization of VIM-2 in the presence of the intact rhodanine led to observation of a ternary complex of MBL, a thioenolate fragment and rhodanine. The crystallographic observations are supported by kinetic and biophysical studies, including (19)F NMR analyses, which reveal the rhodanine-derived thioenolate to be a potent broad-spectrum MBL inhibitor and a lead structure for the development of new types of clinically useful MBL inhibitors.
		+
		+	Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition.,Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17. PMID:25411887<ref>PMID:25411887</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:54, 19 November 2014

2014-11-19T12:54:14Z

←Older revision		Revision as of 12:54, 19 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F==
-		+	<StructureSection load='4pvo' size='340' side='right' caption='[[4pvo]], [[Resolution\|resolution]] 1.48Å' scene=''>
-	~~The entry~~ 4pvo is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pvo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVO FirstGlance]. <br>
-	~~Authors~~: ~~Aik~~, W.S., ~~Brem~~, J., McDonough, M.A., Schofield, C.J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=S3C:(2Z)-2-SULFANYL-3-(2,3,6-TRICHLOROPHENYL)PROP-2-ENOIC+ACID'>S3C</scene>, <scene name='pdbligand=SVB:N-(4-METHYLPIPERAZIN-1-YL)-2-[(5Z)-4-OXO-2-THIOXO-5-(2,3,6-TRICHLOROBENZYLIDENE)-1,3-THIAZOLIDIN-3-YL]ACETAMIDE'>SVB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ko3\|1ko3]], [[1ko2\|1ko2]], [[4pvt\|4pvt]]</td></tr>
-	~~Description~~: ~~Crystal Structure of VIM~~-~~2 MBL in~~ complex ~~with Inhibitor 1~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvo RCSB], [http://www.ebi.ac.uk/pdbsum/4pvo PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aik, W S]]
		+	[[Category: Brem, J]]
		+	[[Category: McDonough, M A]]
		+	[[Category: Schofield, C J]]
		+	[[Category: Alpha-beta/beta-alpha fold]]
		+	[[Category: Beta-lactamase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:35, 30 April 2014

2014-04-30T06:35:14Z

←Older revision		Revision as of 06:35, 30 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pvo is ON HOLD	+	The entry 4pvo is ON HOLD until Paper Publication

	Authors: Aik, W.S., Brem, J., McDonough, M.A., Schofield, C.J.		Authors: Aik, W.S., Brem, J., McDonough, M.A., Schofield, C.J.

	Description: Crystal Structure of VIM-2 MBL in complex with Inhibitor 1		Description: Crystal Structure of VIM-2 MBL in complex with Inhibitor 1

OCA: Protected "4pvo" [edit=sysop:move=sysop]

2014-03-26T08:53:02Z

Protected "4pvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:53, 26 March 2014

OCA: New page: '''Unreleased structure''' The entry 4pvo is ON HOLD Authors: Aik, W.S., Brem, J., McDonough, M.A., Schofield, C.J. Description: Crystal Structure of VIM-2 MBL in complex with Inhibito...

2014-03-26T08:53:01Z

New page: '''Unreleased structure''' The entry 4pvo is ON HOLD Authors: Aik, W.S., Brem, J., McDonough, M.A., Schofield, C.J. Description: Crystal Structure of VIM-2 MBL in complex with Inhibito...

New page

'''Unreleased structure'''

The entry 4pvo is ON HOLD

Authors: Aik, W.S., Brem, J., McDonough, M.A., Schofield, C.J.

Description: Crystal Structure of VIM-2 MBL in complex with Inhibitor 1