4qac - Revision history

OCA at 11:20, 15 February 2023

2023-02-15T11:20:49Z

←Older revision		Revision as of 11:20, 15 February 2023
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	<StructureSection load='4qac' size='340' side='right'caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4qac' size='340' side='right'caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Great_pond_snail Great pond snail~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QAC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QAC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [https://pdbe.org/4qac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [https://www.ebi.ac.uk/pdbsum/4qac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qac ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [~~http~~://pdbe.org/4qac PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qac PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qac ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.	+	[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Great pond snail]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Changeux, J P]]	+	[[Category: Lymnaea stagnalis]]
-	[[Category: Finn~~, M G~~]]	+	[[Category: Changeux J-P]]
-	[[Category: Harel, M]]	+	[[Category: Finn MG]]
-	[[Category: Kaczanowska, K]]	+	[[Category: Harel M]]
-	[[Category: Radic, Z]]	+	[[Category: Kaczanowska K]]
-	[[Category: Taylor, P]]	+	[[Category: Radic Z]]
-	~~[[Category: Acetylcholine-binding protein~~]]	+	[[Category: Taylor P]]

OCA at 08:01, 19 February 2020

2020-02-19T08:01:07Z

←Older revision		Revision as of 08:01, 19 February 2020
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	==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine==		==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine==
-	<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4qac' size='340' side='right'caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 4qac" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qac" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Great pond snail]]		[[Category: Great pond snail]]
		+	[[Category: Large Structures]]
	[[Category: Changeux, J P]]		[[Category: Changeux, J P]]
	[[Category: Finn, M G]]		[[Category: Finn, M G]]

OCA at 20:17, 24 January 2018

2018-01-24T20:17:28Z

←Older revision		Revision as of 20:17, 24 January 2018
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	<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>
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	</div>		</div>
	<div class="pdbe-citations 4qac" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qac" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Great pond snail]]
	[[Category: Changeux, J P]]		[[Category: Changeux, J P]]
	[[Category: Finn, M G]]		[[Category: Finn, M G]]
	[[Category: Harel, M]]		[[Category: Harel, M]]
	[[Category: Kaczanowska, K]]		[[Category: Kaczanowska, K]]
-	[[Category: Radic , Z]]	+	[[Category: Radic, Z]]
	[[Category: Taylor, P]]		[[Category: Taylor, P]]
	[[Category: Acetylcholine-binding protein]]		[[Category: Acetylcholine-binding protein]]

OCA at 10:01, 4 August 2016

2016-08-04T10:01:32Z

←Older revision		Revision as of 10:01, 4 August 2016
Line 1:		Line 1:
		+
	==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine==		==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine==
	<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://pdbe.org/4qac PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qac ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qac" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:39, 24 December 2014

2014-12-24T08:39:49Z

←Older revision		Revision as of 08:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST]] Binds to acetylcholine. Modulates neuronal synaptic transmission.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Changeux, J P.]]	+	[[Category: Changeux, J P]]
-	[[Category: Finn, M G.]]	+	[[Category: Finn, M G]]
-	[[Category: Harel, M.]]	+	[[Category: Harel, M]]
-	[[Category: Kaczanowska, K.]]	+	[[Category: Kaczanowska, K]]
-	[[Category: Radic , Z.]]	+	[[Category: Radic , Z]]
-	[[Category: Taylor, P.]]	+	[[Category: Taylor, P]]
	[[Category: Acetylcholine-binding protein]]		[[Category: Acetylcholine-binding protein]]

OCA at 06:23, 30 July 2014

2014-07-30T06:23:31Z

←Older revision		Revision as of 06:23, 30 July 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nicotinic acetylcholine receptor (nAChR) and the acetylcholine binding protein (AChBP) are pentameric oligomers in which binding sites for nicotinic agonists and competitive antagonists are found at selected subunit interfaces. The nAChR spontaneously exists in multiple conformations associated with its activation and desensitization steps, and conformations are selectively stabilized by binding of agonists and antagonists. In the nAChR, agonist binding and the associated conformational changes accompanying activation and desensitization are cooperative. AChBP, which lacks the transmembrane spanning and cytoplasmic domains, serves as a homology model of the extracellular domain of the nAChRs. We identified unique cooperative binding behavior of a number of 4,6-disubstituted 2-aminopyrimidines to Lymnaea AChBP, with different molecular variants exhibiting positive, nH > 1.0, and negative cooperativity, nH < 1.0. Therefore, for a distinctive set of ligands, the extracellular domain of a nAChR surrogate suffices to accommodate cooperative interactions. X-ray crystal structures of AChBP complexes with examples of each allowed the identification of structural features in the ligands that confer differences in cooperative behavior. Both sets of molecules bind at the agonist-antagonist site, as expected from their competition with epibatidine. An analysis of AChBP quaternary structure shows that cooperative ligand binding is associated with a blooming or flare conformation, a structural change not observed with the classical, noncooperative, nicotinic ligands. Positively and negatively cooperative ligands exhibited unique features in the detailed binding determinants and poses of the complexes.
		+
		+	Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.,Kaczanowska K, Harel M, Radic Z, Changeux JP, Finn MG, Taylor P Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10749-54. doi:, 10.1073/pnas.1410992111. Epub 2014 Jul 8. PMID:25006260<ref>PMID:25006260</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:33, 16 July 2014

2014-07-16T10:33:31Z

←Older revision		Revision as of 10:33, 16 July 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine==
-		+	<StructureSection load='4qac' size='340' side='right' caption='[[4qac]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry 4qac is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qac]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAC FirstGlance]. <br>
-	~~Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P.~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KK3:4-(4-METHYLPIPERIDIN-1-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE'>KK3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ux2\|1ux2]], [[1uw6\|1uw6]], [[1uv6\|1uv6]], [[4qaa\|4qaa]], [[4qab\|4qab]]</td></tr>
-	~~Description:~~ X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qac RCSB], [http://www.ebi.ac.uk/pdbsum/4qac PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Changeux, J P.]]
		+	[[Category: Finn, M G.]]
		+	[[Category: Harel, M.]]
		+	[[Category: Kaczanowska, K.]]
		+	[[Category: Radic , Z.]]
		+	[[Category: Taylor, P.]]
		+	[[Category: Acetylcholine-binding protein]]

OCA at 05:52, 25 June 2014

2014-06-25T05:52:28Z

←Older revision		Revision as of 05:52, 25 June 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qac is ON HOLD	+	The entry 4qac is ON HOLD until Paper Publication

	Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P.		Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P.

	Description: X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine		Description: X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine

OCA: Protected "4qac" [edit=sysop:move=sysop]

2014-05-14T07:10:50Z

Protected "4qac" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:10, 14 May 2014

OCA: New page: '''Unreleased structure''' The entry 4qac is ON HOLD Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P. Description: X-RAY STRUCTURE OF ACETYLCHOL...

2014-05-14T07:10:49Z

New page: '''Unreleased structure''' The entry 4qac is ON HOLD Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P. Description: X-RAY STRUCTURE OF ACETYLCHOL...

New page

'''Unreleased structure'''

The entry 4qac is ON HOLD

Authors: Kaczanowska, K., Harel, M., Radic', Z., Changeux, J.-P., Finn, M.G., Taylor, P.

Description: X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine