4qd2 - Revision history

OCA at 17:31, 20 September 2023

2023-09-20T17:31:01Z

←Older revision		Revision as of 17:31, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [https://pdbe.org/4qd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [https://pdbe.org/4qd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:23, 15 February 2023

2023-02-15T11:23:38Z

←Older revision		Revision as of 11:23, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4qd2' size='340' side='right'caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4qd2' size='340' side='right'caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Clobh Clobh~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70, CBO0801, CLC_0857 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), ha17, CBO0802, CLC_0858 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), ha33, CBO0803, CLC_0859 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [https://pdbe.org/4qd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [~~http~~://pdbe.org/4qd2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CADH1_MOUSE CADH1_MOUSE~~]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).	+	[https://www.uniprot.org/uniprot/A5HZZ6_CLOBH A5HZZ6_CLOBH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	==See Also==		==See Also==
	*[[Cadherin 3D structures\|Cadherin 3D structures]]		*[[Cadherin 3D structures\|Cadherin 3D structures]]
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clobh~~]]	+	[[Category: Clostridium botulinum A str. Hall]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Dong, M]]	+	[[Category: Dong M]]
-	[[Category: Dorner~~, M B~~]]	+	[[Category: Dorner MB]]
-	[[Category: Gu, S]]	+	[[Category: Gu S]]
-	[[Category: Jin, R]]	+	[[Category: Jin R]]
-	[[Category: Kruel, A]]	+	[[Category: Kruel A]]
-	[[Category: Lee, K]]	+	[[Category: Lee K]]
-	[[Category: Perry, K]]	+	[[Category: Perry K]]
-	[[Category: Rummel, A]]	+	[[Category: Rummel A]]
-	[[Category: Zhong, X]]	+	[[Category: Zhong X]]
-	~~[[Category: Botulinum neurotoxin]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: E-cadherin]]~~	+
-	~~[[Category: Ha17]]~~	+
-	~~[[Category: Ha33]]~~	+
-	~~[[Category: Ha70]]~~	+
-	~~[[Category: Oral toxicity~~]]	+

OCA at 09:00, 24 April 2019

2019-04-24T09:00:16Z

←Older revision		Revision as of 09:00, 24 April 2019
Line 1:		Line 1:

	==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==		==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==
-	<StructureSection load='4qd2' size='340' side='right' caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4qd2' size='340' side='right'caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Clobh Clobh] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70, CBO0801, CLC_0857 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), ha17, CBO0802, CLC_0858 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), ha33, CBO0803, CLC_0859 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH]), Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://pdbe.org/4qd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://pdbe.org/4qd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Cadherin\|Cadherin]]	+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clobh]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Dong, M]]		[[Category: Dong, M]]
	[[Category: Dorner, M B]]		[[Category: Dorner, M B]]

OCA at 08:50, 4 August 2016

2016-08-04T08:50:36Z

←Older revision		Revision as of 08:50, 4 August 2016
Line 1:		Line 1:
		+
	==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==		==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==
	<StructureSection load='4qd2' size='340' side='right' caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4qd2' size='340' side='right' caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://pdbe.org/4qd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qd2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin\|Cadherin]]
		+	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:30, 25 December 2014

2014-12-25T07:30:58Z

←Older revision		Revision as of 07:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dong, M.]]	+	[[Category: Dong, M]]
-	[[Category: Dorner, M B.]]	+	[[Category: Dorner, M B]]
-	[[Category: Gu, S.]]	+	[[Category: Gu, S]]
-	[[Category: Jin, R.]]	+	[[Category: Jin, R]]
-	[[Category: Kruel, A.]]	+	[[Category: Kruel, A]]
-	[[Category: Lee, K.]]	+	[[Category: Lee, K]]
-	[[Category: Perry, K.]]	+	[[Category: Perry, K]]
-	[[Category: Rummel, A.]]	+	[[Category: Rummel, A]]
-	[[Category: Zhong, X.]]	+	[[Category: Zhong, X]]
	[[Category: Botulinum neurotoxin]]		[[Category: Botulinum neurotoxin]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 06:19, 2 July 2014

2014-07-02T06:19:14Z

←Older revision		Revision as of 06:19, 2 July 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How botulinum neurotoxins (BoNTs) cross the host intestinal epithelial barrier in foodborne botulism is poorly understood. Here, we present the crystal structure of a clostridial hemagglutinin (HA) complex of serotype BoNT/A bound to the cell adhesion protein E-cadherin at 2.4 angstroms. The HA complex recognizes E-cadherin with high specificity involving extensive intermolecular interactions and also binds to carbohydrates on the cell surface. Binding of the HA complex sequesters E-cadherin in the monomeric state, compromising the E-cadherin-mediated intercellular barrier and facilitating paracellular absorption of BoNT/A. We reconstituted the complete 14-subunit BoNT/A complex using recombinantly produced components and demonstrated that abolishing either E-cadherin- or carbohydrate-binding of the HA complex drastically reduces oral toxicity of BoNT/A complex in vivo. Together, these studies establish the molecular mechanism of how HAs contribute to the oral toxicity of BoNT/A.
		+
		+	Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.,Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R Science. 2014 Jun 20;344(6190):1405-10. doi: 10.1126/science.1253823. PMID:24948737<ref>PMID:24948737</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:38, 25 June 2014

2014-06-25T06:38:30Z

←Older revision		Revision as of 06:38, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex==
-		+	<StructureSection load='4qd2' size='340' side='right' caption='[[4qd2]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~The entry~~ 4qd2 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qd2]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QD2 FirstGlance]. <br>
-	~~Authors~~: ~~Lee~~, K., ~~Zhong~~, X., Gu, S., Kruel, A., ~~Dorner, M~~.~~B.,~~ Perry, K., Rummel, A., ~~Dong, M., Jin, R~~.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qd2 PDBsum]</span></td></tr>
-	~~Description~~: ~~Molecular basis for disruption of~~ E-cadherin ~~adhesion by botulinum neurotoxin A complex~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dong, M.]]
		+	[[Category: Dorner, M B.]]
		+	[[Category: Gu, S.]]
		+	[[Category: Jin, R.]]
		+	[[Category: Kruel, A.]]
		+	[[Category: Lee, K.]]
		+	[[Category: Perry, K.]]
		+	[[Category: Rummel, A.]]
		+	[[Category: Zhong, X.]]
		+	[[Category: Botulinum neurotoxin]]
		+	[[Category: Cell adhesion]]
		+	[[Category: E-cadherin]]
		+	[[Category: Ha17]]
		+	[[Category: Ha33]]
		+	[[Category: Ha70]]
		+	[[Category: Oral toxicity]]

OCA at 06:34, 18 June 2014

2014-06-18T06:34:48Z

←Older revision		Revision as of 06:34, 18 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qd2 is ON HOLD	+	The entry 4qd2 is ON HOLD until Paper Publication

	Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.		Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.

	Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex		Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

OCA at 08:03, 11 June 2014

2014-06-11T08:03:24Z

←Older revision		Revision as of 08:03, 11 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qd2 is ON HOLD ~~until Paper Publication~~	+	The entry 4qd2 is ON HOLD

	Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.		Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.

	Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex		Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

OCA at 04:57, 4 June 2014

2014-06-04T04:57:48Z

←Older revision		Revision as of 04:57, 4 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qd2 is ON HOLD	+	The entry 4qd2 is ON HOLD until Paper Publication

	Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.		Authors: Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.

	Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex		Description: Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex