4qe6 - Revision history

OCA: Redirecting to 6hl1

2023-03-02T05:56:23Z

Redirecting to 6hl1

←Older revision		Revision as of 05:56, 2 March 2023
Line 1:		Line 1:
-		+	#REDIRECT [[6hl1]] This PDB entry is obsolete and replaced by 6hl1
-	~~==FXR with CDCA and NCoA-2 peptide==~~	+
-	~~<StructureSection load='4qe6' size='340' side='right'caption='~~[[~~4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[4qe6~~]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [https://pdbe.org/4qe6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid~~ and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>	+
-		+
-	~~==See Also==~~	+
-	*[[Bile acid receptor 3D structures\|Bile acid receptor 3D structures]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Bamberg K]]~~	+
-	~~[[Category: Dekker N]]~~	+
-	~~[[Category: Kudlinzki D]]~~	+
-	~~[[Category: Linhard VL]]~~	+
-	~~[[Category: Merk D]]~~	+
-	~~[[Category: Nilsson E]]~~	+
-	~~[[Category: Saxena K]]~~	+
-	~~[[Category: Schubert-Zsilavecz M]]~~	+
-	~~[[Category: Schwalbe H]]~~	+
-	~~[[Category: Sreeramulu S]]~~	+
-	~~[[Category: Wissler L]]~~	+

OCA at 11:25, 15 February 2023

2023-02-15T11:25:14Z

←Older revision		Revision as of 11:25, 15 February 2023
Line 1:		Line 1:

	==FXR with CDCA and NCoA-2 peptide==		==FXR with CDCA and NCoA-2 peptide==
-	<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4qe6' size='340' side='right'caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [https://pdbe.org/4qe6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR1H4, BAR, FXR, HRR1, RIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [~~http~~://pdbe.org/4qe6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[~~http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN~~]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>	+	[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
		+
		+	==See Also==
		+	*[[Bile acid receptor 3D structures\|Bile acid receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Bamberg, K]]	+	[[Category: Large Structures]]
-	[[Category: Dekker, N]]	+	[[Category: Bamberg K]]
-	[[Category: Kudlinzki, D]]	+	[[Category: Dekker N]]
-	[[Category: Linhard~~, V L~~]]	+	[[Category: Kudlinzki D]]
-	[[Category: Merk, D]]	+	[[Category: Linhard VL]]
-	[[Category: Nilsson, E]]	+	[[Category: Merk D]]
-	[[Category: Saxena, K]]	+	[[Category: Nilsson E]]
-	[[Category: Schubert-Zsilavecz, M]]	+	[[Category: Saxena K]]
-	[[Category: Schwalbe, H]]	+	[[Category: Schubert-Zsilavecz M]]
-	[[Category: Sreeramulu, S]]	+	[[Category: Schwalbe H]]
-	[[Category: Wissler, L]]	+	[[Category: Sreeramulu S]]
-	~~[[Category: Bile acid receptor dna]]~~	+	[[Category: Wissler L]]
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:52, 22 November 2017

2017-11-22T08:52:20Z

←Older revision		Revision as of 08:52, 22 November 2017
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	<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR1H4, BAR, FXR, HRR1, RIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://pdbe.org/4qe6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://pdbe.org/4qe6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
	</table>		</table>
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>		[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
-
-	==See Also==
-	*[[Bile acid receptor\|Bile acid receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bamberg, K]]		[[Category: Bamberg, K]]
	[[Category: Dekker, N]]		[[Category: Dekker, N]]

OCA at 16:11, 17 May 2017

2017-05-17T16:11:34Z

←Older revision		Revision as of 16:11, 17 May 2017
Line 1:		Line 1:
		+
	==FXR with CDCA and NCoA-2 peptide==		==FXR with CDCA and NCoA-2 peptide==
	<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://pdbe.org/4qe6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>		[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
		+
		+	==See Also==
		+	*[[Bile acid receptor\|Bile acid receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:44, 12 August 2015

2015-08-12T14:44:41Z

←Older revision		Revision as of 14:44, 12 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==FXR with CDCA and NCoA-2 peptide==
-		+	<StructureSection load='4qe6' size='340' side='right' caption='[[4qe6]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~The entry~~ 4qe6 is ~~ON HOLD until Aug 15 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
-	~~Authors~~: ~~Kudlinzki, D~~.~~, Merk, D~~.~~, Linhard, V~~.L.~~, Saxena, K~~., ~~Sreeramulu~~, S., ~~Schubert~~-~~Zsilavecz~~, M., ~~Schwalbe~~, H.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qe8\|4qe8]]</td></tr>
-	~~Description~~: ~~FXR with CDCA~~ and ~~NCoA~~-2 ~~petide~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe6 PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Linhard~~, ~~V.L~~]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bamberg, K]]
		+	[[Category: Dekker, N]]
	[[Category: Kudlinzki, D]]		[[Category: Kudlinzki, D]]
		+	[[Category: Linhard, V L]]
		+	[[Category: Merk, D]]
		+	[[Category: Nilsson, E]]
	[[Category: Saxena, K]]		[[Category: Saxena, K]]
	[[Category: Schubert-Zsilavecz, M]]		[[Category: Schubert-Zsilavecz, M]]
-	[[Category: Merk, D]]
	[[Category: Schwalbe, H]]		[[Category: Schwalbe, H]]
	[[Category: Sreeramulu, S]]		[[Category: Sreeramulu, S]]
		+	[[Category: Wissler, L]]
		+	[[Category: Bile acid receptor dna]]
		+	[[Category: Receptor]]
		+	[[Category: Transcription]]

OCA at 08:21, 6 May 2015

2015-05-06T08:21:52Z

←Older revision		Revision as of 08:21, 6 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qe6 is ON HOLD until ~~Jun~~ 15 2016	+	The entry 4qe6 is ON HOLD until Aug 15 2016

	Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.		Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.

OCA at 08:05, 15 April 2015

2015-04-15T08:05:45Z

←Older revision		Revision as of 08:05, 15 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qe6 is ON HOLD until ~~Paper Publication~~	+	The entry 4qe6 is ON HOLD until Jun 15 2016

	Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.		Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.

OCA at 15:40, 24 December 2014

2014-12-24T15:40:43Z

←Older revision		Revision as of 15:40, 24 December 2014
Line 6:		Line 6:

	Description: FXR with CDCA and NCoA-2 petide		Description: FXR with CDCA and NCoA-2 petide
		+	[[Category: Unreleased Structures]]
		+	[[Category: Linhard, V.L]]
		+	[[Category: Kudlinzki, D]]
		+	[[Category: Saxena, K]]
		+	[[Category: Schubert-Zsilavecz, M]]
		+	[[Category: Merk, D]]
		+	[[Category: Schwalbe, H]]
		+	[[Category: Sreeramulu, S]]

OCA at 08:03, 11 June 2014

2014-06-11T08:03:48Z

←Older revision		Revision as of 08:03, 11 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qe6 is ON HOLD	+	The entry 4qe6 is ON HOLD until Paper Publication

-	Authors: Kudlinzki, D., Merk, D., ~~Linhardt~~, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.	+	Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Sreeramulu, S., Schubert-Zsilavecz, M., Schwalbe, H.

	Description: FXR with CDCA and NCoA-2 petide		Description: FXR with CDCA and NCoA-2 petide

OCA: Protected "4qe6" [edit=sysop:move=sysop]

2014-05-21T08:20:10Z

Protected "4qe6" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 21 May 2014