4qh7 - Revision history

OCA at 17:32, 20 September 2023

2023-09-20T17:32:12Z

←Older revision		Revision as of 17:32, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [https://pdbe.org/4qh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.829Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [https://pdbe.org/4qh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:29, 15 February 2023

2023-02-15T11:29:49Z

←Older revision		Revision as of 11:29, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='4qh7' size='340' side='right'caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4qh7' size='340' side='right'caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [https://pdbe.org/4qh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [~~http~~://pdbe.org/4qh7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity).	+	[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME] Acts as a non-catalytic accessory component of a dynein complex (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
-	*[[Dynein\|Dynein]]	+	*[[Dynein 3D structures\|Dynein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Romes~~, E R~~]]	+	[[Category: Romes ER]]
-	[[Category: Slep~~, K C~~]]	+	[[Category: Slep KC]]
-	[[Category: Slevin~~, L K]]~~	+	[[Category: Slevin LK]]
-	~~[[Category: Ana2]]~~	+
-	~~[[Category: Cellular]]~~	+
-	~~[[Category: Lc8 fold dimer]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Target dimerization~~]]	+

OCA at 08:36, 24 April 2019

2019-04-24T08:36:41Z

←Older revision		Revision as of 08:36, 24 April 2019
Line 1:		Line 1:

	==LC8 - Ana2 (159-168) Complex==		==LC8 - Ana2 (159-168) Complex==
-	<StructureSection load='4qh7' size='340' side='right' caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='4qh7' size='340' side='right'caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctp, Cdlc1, ddlc1, CG6998 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://pdbe.org/4qh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://pdbe.org/4qh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Romes, E R]]		[[Category: Romes, E R]]
	[[Category: Slep, K C]]		[[Category: Slep, K C]]

OCA at 05:18, 5 August 2016

2016-08-05T05:18:53Z

←Older revision		Revision as of 05:18, 5 August 2016
Line 1:		Line 1:
		+
	==LC8 - Ana2 (159-168) Complex==		==LC8 - Ana2 (159-168) Complex==
	<StructureSection load='4qh7' size='340' side='right' caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4qh7' size='340' side='right' caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://pdbe.org/4qh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qh7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynein\|Dynein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:04, 25 December 2014

2014-12-25T16:04:37Z

←Older revision		Revision as of 16:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME]] Acts as a non-catalytic accessory component of a dynein complex (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Romes, E R.]]	+	[[Category: Romes, E R]]
-	[[Category: Slep, K C.]]	+	[[Category: Slep, K C]]
-	[[Category: Slevin, L K.]]	+	[[Category: Slevin, L K]]
	[[Category: Ana2]]		[[Category: Ana2]]
	[[Category: Cellular]]		[[Category: Cellular]]

OCA at 13:24, 20 August 2014

2014-08-20T13:24:58Z

←Older revision		Revision as of 13:24, 20 August 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centrioles play a key role in nucleating polarized microtubule networks. In actively dividing cells, centrioles establish the bipolar mitotic spindle and are essential for genomic stability. Drosophila anastral spindle-2 (Ana2) is a conserved centriole duplication factor. Although recent work has demonstrated that an Ana2-dynein light chain (LC8) centriolar complex is critical for proper spindle positioning in neuroblasts, how Ana2 and LC8 interact is yet to be established. Here we examine the Ana2-LC8 interaction and map two LC8-binding sites within the central region of Ana2, Ana2M (residues 156-251). Ana2 LC8-binding site 1 contains a signature TQT motif and robustly binds LC8 (KD of 1.1 mum), whereas site 2 contains a TQC motif and binds LC8 with lower affinity (KD of 13 mum). Both LC8-binding sites flank a predicted approximately 34-residue alpha-helix. We present two independent atomic structures of LC8 dimers in complex with Ana2 LC8-binding site 1 and site 2 peptides. The Ana2 peptides form beta-strands that extend a central composite LC8 beta-sandwich. LC8 recognizes the signature TQT motif in the first LC8 binding site of Ana2, forming extensive van der Waals contacts and hydrogen bonding with the peptide, whereas the Ana2 site 2 TQC motif forms a uniquely extended beta-strand, not observed in other dynein light chain-target complexes. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex. LC8-mediated Ana2 oligomerization probably enhances Ana2 avidity for centriole-binding factors and may bridge multiple factors as required during spindle positioning and centriole biogenesis.
		+
		+	The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor.,Slevin LK, Romes EM, Dandulakis MG, Slep KC J Biol Chem. 2014 Jul 25;289(30):20727-39. doi: 10.1074/jbc.M114.576041. Epub, 2014 Jun 11. PMID:24920673<ref>PMID:24920673</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:59, 11 June 2014

2014-06-11T08:59:31Z

←Older revision		Revision as of 08:59, 11 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==LC8 - Ana2 (159-168) Complex==
-		+	<StructureSection load='4qh7' size='340' side='right' caption='[[4qh7]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~The entry~~ 4qh7 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qh7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH7 FirstGlance]. <br>
-	~~Authors~~: ~~Slevin~~, L.K., Romes, E.R., Slep, K.C.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qh8\|4qh8]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh7 PDBsum]</span></td></tr>
-	~~Description~~: ~~LC8 -~~Ana2 ~~(159-168) Complex~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Romes, E R.]]
		+	[[Category: Slep, K C.]]
		+	[[Category: Slevin, L K.]]
		+	[[Category: Ana2]]
		+	[[Category: Cellular]]
		+	[[Category: Lc8 fold dimer]]
		+	[[Category: Motor protein]]
		+	[[Category: Target dimerization]]

OCA: Protected "4qh7" [edit=sysop:move=sysop]

2014-06-04T04:58:48Z

Protected "4qh7" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qh7 is ON HOLD Authors: Slevin, L.K., Romes, E.R., Slep, K.C. Description: LC8 -Ana2 (159-168) Complex

2014-06-04T04:58:48Z

New page: '''Unreleased structure''' The entry 4qh7 is ON HOLD Authors: Slevin, L.K., Romes, E.R., Slep, K.C. Description: LC8 -Ana2 (159-168) Complex

New page

'''Unreleased structure'''

The entry 4qh7 is ON HOLD

Authors: Slevin, L.K., Romes, E.R., Slep, K.C.

Description: LC8 -Ana2 (159-168) Complex