4qn2 - Revision history

OCA at 17:33, 20 September 2023

2023-09-20T17:33:46Z

←Older revision		Revision as of 17:33, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [https://pdbe.org/4qn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [https://pdbe.org/4qn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:41, 22 February 2023

2023-02-22T13:41:03Z

←Older revision		Revision as of 13:41, 22 February 2023
Line 1:		Line 1:

	==2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289==		==2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289==
-	<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4qn2' size='340' side='right'caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staac Staac~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [https://pdbe.org/4qn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">betB, SACOL2628 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [~~http~~://pdbe.org/4qn2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2X0S3_STAAC A0A0H2X0S3_STAAC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4qn2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qn2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Betaine-aldehyde dehydrogenase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Staac~~]]	+	[[Category: Staphylococcus aureus subsp. aureus COL]]
-	[[Category: Anderson~~, W F]]~~	+	[[Category: Anderson WF]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Chen C]]
-	[[Category: Chen, C]]	+	[[Category: Halavaty AS]]
-	[[Category: Halavaty~~, A S~~]]	+	[[Category: Joo JC]]
-	[[Category: Joo~~, J C~~]]	+	[[Category: Minasov G]]
-	[[Category: Minasov, G]]	+	[[Category: Yakunin AF]]
-	[[Category: Yakunin~~, A F]]~~	+
-	~~[[Category: Betb]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: National institute of allergy and infectious disease]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 08:55, 22 November 2017

2017-11-22T08:55:32Z

←Older revision		Revision as of 08:55, 22 November 2017
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	<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">betB, SACOL2628 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://pdbe.org/4qn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://pdbe.org/4qn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4qn2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4qn2" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Betaine-aldehyde dehydrogenase]]		[[Category: Betaine-aldehyde dehydrogenase]]
		+	[[Category: Staac]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 17:27, 9 March 2017

2017-03-09T17:27:15Z

←Older revision		Revision as of 17:27, 9 March 2017
Line 1:		Line 1:
		+
	==2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289==		==2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289==
	<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://pdbe.org/4qn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qn2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:59, 3 June 2015

2015-06-03T06:59:41Z

←Older revision		Revision as of 06:59, 3 June 2015
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	When exposed to high osmolarity, methicillin-resistant Staphylococcus aureus (MRSA) restores its growth and establishes a new steady state by accumulating the osmoprotectant metabolite betaine. Effective osmoregulation has also been implicated in the acquirement of a profound antibiotic resistance by MRSA. Betaine can be obtained from the bacterial habitat or produced intracellularly from choline via the toxic betaine aldehyde (BA) employing the choline dehydrogenase and betaine aldehyde dehydrogenase (BADH) enzymes. Here, it is shown that the putative betaine aldehyde dehydrogenase SACOL2628 from the early MRSA isolate COL (SaBADH) utilizes betaine aldehyde as the primary substrate and nicotinamide adenine dinucleotide (NAD(+)) as the cofactor. Surface plasmon resonance experiments revealed that the affinity of NAD(+), NADH and BA for SaBADH is affected by temperature, pH and buffer composition. Five crystal structures of the wild type and three structures of the Gly234Ser mutant of SaBADH in the apo and holo forms provide details of the molecular mechanisms of activity and substrate specificity/inhibition of this enzyme.
		+
		+	Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus.,Halavaty AS, Rich RL, Chen C, Joo JC, Minasov G, Dubrovska I, Winsor JR, Myszka DG, Duban M, Shuvalova L, Yakunin AF, Anderson WF Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1159-75. doi:, 10.1107/S1399004715004228. Epub 2015 Apr 25. PMID:25945581<ref>PMID:25945581</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]		*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:30, 13 May 2015

2015-05-13T06:30:06Z

←Older revision		Revision as of 06:30, 13 May 2015
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:36, 5 January 2015

2015-01-05T08:36:41Z

←Older revision		Revision as of 08:36, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Betaine-aldehyde dehydrogenase]]		[[Category: Betaine-aldehyde dehydrogenase]]
-	[[Category: Anderson, W F.]]	+	[[Category: Anderson, W F]]
-	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Chen, C.]]	+	[[Category: Chen, C]]
-	[[Category: Halavaty, A S.]]	+	[[Category: Halavaty, A S]]
-	[[Category: Joo, J C.]]	+	[[Category: Joo, J C]]
-	[[Category: Minasov, G.]]	+	[[Category: Minasov, G]]
-	[[Category: Yakunin, A F.]]	+	[[Category: Yakunin, A F]]
	[[Category: Betb]]		[[Category: Betb]]
-	[[Category: Center for structural genomics of infectious disease]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Nad]]		[[Category: Nad]]
Line 26:		Line 25:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-	[[Category: Structural genomic]]

OCA at 08:20, 2 July 2014

2014-07-02T08:20:25Z

←Older revision		Revision as of 08:20, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289==
-		+	<StructureSection load='4qn2' size='340' side='right' caption='[[4qn2]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~The entry~~ 4qn2 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4qn2]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ni4 4ni4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN2 FirstGlance]. <br>
-	~~Authors~~: ~~Halavaty~~, ~~A.S.~~, ~~Minasov~~, G., ~~Chen~~, C., ~~Joo~~, J.C., ~~Yakunin, A~~.F., Anderson, W.F., Center for Structural Genomics of Infectious Diseases ~~(CSGID)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpb\|4mpb]], [[4mpy\|4mpy]], [[4nea\|4nea]], [[4q92\|4q92]], [[4nu9\|4nu9]], [[4qje\|4qje]]</td></tr>
-	~~Description~~: 2.~~6 Angstrom resolution crystal structure~~ of ~~betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+~~ and ~~BME-free Cys289~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Betaine-aldehyde_dehydrogenase Betaine-aldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.8 1.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn2 PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Betaine-aldehyde dehydrogenase]]
		+	[[Category: Anderson, W F.]]
		+	[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
		+	[[Category: Chen, C.]]
		+	[[Category: Halavaty, A S.]]
		+	[[Category: Joo, J C.]]
		+	[[Category: Minasov, G.]]
		+	[[Category: Yakunin, A F.]]
		+	[[Category: Betb]]
		+	[[Category: Center for structural genomics of infectious disease]]
		+	[[Category: Csgid]]
		+	[[Category: Nad]]
		+	[[Category: National institute of allergy and infectious disease]]
		+	[[Category: Niaid]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Structural genomic]]

OCA: Protected "4qn2" [edit=sysop:move=sysop]

2014-06-25T05:58:11Z

Protected "4qn2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4qn2 is ON HOLD Authors: Halavaty, A.S., Minasov, G., Chen, C., Joo, J.C., Yakunin, A.F., Anderson, W.F., Center for Structural Genomics of Infectio...

2014-06-25T05:58:10Z

New page: '''Unreleased structure''' The entry 4qn2 is ON HOLD Authors: Halavaty, A.S., Minasov, G., Chen, C., Joo, J.C., Yakunin, A.F., Anderson, W.F., Center for Structural Genomics of Infectio...

New page

'''Unreleased structure'''

The entry 4qn2 is ON HOLD

Authors: Halavaty, A.S., Minasov, G., Chen, C., Joo, J.C., Yakunin, A.F., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: 2.6 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) in complex with NAD+ and BME-free Cys289