4qzs - Revision history

OCA at 17:41, 20 September 2023

2023-09-20T17:41:35Z

←Older revision		Revision as of 17:41, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [https://pdbe.org/4qzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [https://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [https://pdbe.org/4qzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [https://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 14:00, 22 February 2023

2023-02-22T14:00:57Z

←Older revision		Revision as of 14:00, 22 February 2023
Line 3:		Line 3:
	<StructureSection load='4qzs' size='340' side='right'caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4qzs' size='340' side='right'caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4QZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QZS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [https://pdbe.org/4qzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [https://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [~~http~~://pdbe.org/4qzs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ember~~, S W~~]]	+	[[Category: Ember SW]]
-	[[Category: Schonbrunn, E]]	+	[[Category: Schonbrunn E]]
-	~~[[Category: Cap]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Mcap]]~~	+
-	~~[[Category: Mitotic chromosome associated protein]]~~	+
-	~~[[Category: Protein binding-inhibitor complex]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:44, 24 April 2019

2019-04-24T08:44:05Z

←Older revision		Revision as of 08:44, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1==		==Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1==
-	<StructureSection load='4qzs' size='340' side='right' caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4qzs' size='340' side='right'caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [http://pdbe.org/4qzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [http://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [http://pdbe.org/4qzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [http://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ember, S W]]		[[Category: Ember, S W]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]

OCA at 17:46, 11 August 2016

2016-08-11T17:46:36Z

←Older revision		Revision as of 17:46, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1==		==Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1==
	<StructureSection load='4qzs' size='340' side='right' caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4qzs' size='340' side='right' caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [http://www.ebi.ac.uk/pdbsum/4qzs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [http://pdbe.org/4qzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [http://www.ebi.ac.uk/pdbsum/4qzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qzs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4qzs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:20, 21 January 2015

2015-01-21T11:20:10Z

←Older revision		Revision as of 11:20, 21 January 2015
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ember, S W.]]	+	[[Category: Ember, S W]]
-	[[Category: Schonbrunn, E.]]	+	[[Category: Schonbrunn, E]]
	[[Category: Cap]]		[[Category: Cap]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 11:17, 29 October 2014

2014-10-29T11:17:23Z

←Older revision		Revision as of 11:17, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1==
		+	<StructureSection load='4qzs' size='340' side='right' caption='[[4qzs]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4qzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QZS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQ1:(6S)-6-(2-TERT-BUTOXY-2-OXOETHYL)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6,7-DIHYDROTHIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-10-IUM'>JQ1</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qzs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qzs RCSB], [http://www.ebi.ac.uk/pdbsum/4qzs PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe a 19F NMR method for detecting bromodomain-ligand interactions using fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the bromodomain binding site. We test the sensitivity, accuracy, and speed of this method with small molecule ligands (+)-JQ1, BI2536, Dinaciclib, TG101348, and acetaminophen using three bromodomains Brd4, BrdT, and BPTF. Simplified 19F NMR spectra allowed for simultaneous testing of multiple bromodomains to assess selectivity and identification of a new BPTF ligand. Fluorine labeling only modestly affected the Brd4 structure and function assessed by isothermal titration calorimetry, circular dichroism, and X-ray crystallography. The speed, ease of interpretation, and low concentration of protein needed for binding experiments affords a new method to discover and characterize both native and new ligands.

-	~~The entry 4qzs is ON HOLD until Paper Publication~~	+	Fluorinated Aromatic Amino Acids Are Sensitive F NMR Probes for Bromodomain-Ligand Interactions.,Mishra NK, Urick AK, Ember SW, Schonbrunn E, Pomerantz WC ACS Chem Biol. 2014 Oct 27. PMID:25290579<ref>PMID:25290579</ref>

-	~~Authors~~: Ember, S.W., Schonbrunn, E.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of the first bromodomain of human 3~~-~~fluoro tyrosine-labeled brd4 in~~ complex ~~with jq1~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ember, S W.]]
		+	[[Category: Schonbrunn, E.]]
		+	[[Category: Cap]]
		+	[[Category: Cell cycle]]
		+	[[Category: Inhibitor]]
		+	[[Category: Mcap]]
		+	[[Category: Mitotic chromosome associated protein]]
		+	[[Category: Protein binding-inhibitor complex]]
		+	[[Category: Transcription]]

OCA at 23:04, 1 October 2014

2014-10-01T23:04:57Z

←Older revision		Revision as of 23:04, 1 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4qzs is ON HOLD	+	The entry 4qzs is ON HOLD until Paper Publication

	Authors: Ember, S.W., Schonbrunn, E.		Authors: Ember, S.W., Schonbrunn, E.

	Description: Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1		Description: Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1

OCA at 07:46, 13 August 2014

2014-08-13T07:46:03Z

←Older revision		Revision as of 07:46, 13 August 2014
Line 5:		Line 5:
	Authors: Ember, S.W., Schonbrunn, E.		Authors: Ember, S.W., Schonbrunn, E.

-	Description: ~~CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN~~ 3-~~FLUORO TYROSINE~~-~~LABELED BRD4 IN COMPLEX WITH JQ1~~	+	Description: Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1

OCA: Protected "4qzs" [edit=sysop:move=sysop]

2014-08-07T01:16:01Z

Protected "4qzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:16, 7 August 2014

OCA: New page: '''Unreleased structure''' The entry 4qzs is ON HOLD Authors: Ember, S.W., Schonbrunn, E. Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN 3-FLUORO TYROSINE-LABELED BRD...

2014-08-07T01:16:00Z

New page: '''Unreleased structure''' The entry 4qzs is ON HOLD Authors: Ember, S.W., Schonbrunn, E. Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN 3-FLUORO TYROSINE-LABELED BRD...

New page

'''Unreleased structure'''

The entry 4qzs is ON HOLD

Authors: Ember, S.W., Schonbrunn, E.

Description: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN 3-FLUORO TYROSINE-LABELED BRD4 IN COMPLEX WITH JQ1