4r68 - Revision history

OCA at 17:44, 20 September 2023

2023-09-20T17:44:48Z

←Older revision		Revision as of 17:44, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R68 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.112Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [https://pdbe.org/4r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [https://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [https://pdbe.org/4r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [https://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:41, 2 March 2023

2023-03-02T06:41:56Z

←Older revision		Revision as of 06:41, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4r68' size='340' side='right'caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4r68' size='340' side='right'caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4R68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [https://pdbe.org/4r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [https://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [~~http~~://pdbe.org/4r68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[~~http~~://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>	+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: L-lactate dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eigenbrot, C]]	+	[[Category: Eigenbrot C]]
-	[[Category: Ultsch, M]]	+	[[Category: Ultsch M]]
-	~~[[Category: Nicotinamide adenine dinucleaotide]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:17, 1 May 2019

2019-05-01T10:17:01Z

←Older revision		Revision as of 10:17, 1 May 2019
Line 1:		Line 1:

	==Lactate Dehydrogenase in complex with inhibitor compound 31==		==Lactate Dehydrogenase in complex with inhibitor compound 31==
-	<StructureSection load='4r68' size='340' side='right' caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='4r68' size='340' side='right'caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://pdbe.org/4r68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://pdbe.org/4r68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4r68" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4r68" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot, C]]
	[[Category: Ultsch, M]]		[[Category: Ultsch, M]]
	[[Category: Nicotinamide adenine dinucleaotide]]		[[Category: Nicotinamide adenine dinucleaotide]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 23:25, 4 August 2016

2016-08-04T23:25:35Z

←Older revision		Revision as of 23:25, 4 August 2016
Line 1:		Line 1:
		+
	==Lactate Dehydrogenase in complex with inhibitor compound 31==		==Lactate Dehydrogenase in complex with inhibitor compound 31==
	<StructureSection load='4r68' size='340' side='right' caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='4r68' size='340' side='right' caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://pdbe.org/4r68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4r68" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:54, 24 December 2014

2014-12-24T10:54:08Z

←Older revision		Revision as of 10:54, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Lactate Dehydrogenase in complex with inhibitor compound 31==
		+	<StructureSection load='4r68' size='340' side='right' caption='[[4r68]], [[Resolution\|resolution]] 2.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4r69\|4r69]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enone using structure-based design strategies resulted in inhibitors with considerable improvement in biochemical potency against human lactate dehydrogenase A (LDHA). These potent inhibitors were typically selective for LDHA over LDHB isoform (4-10 fold) and other structurally related malate dehydrogenases, MDH1 and MDH2 (>500 fold). An X-ray crystal structure of enzymatically most potent molecule bound to LDHA revealed two additional interactions associated with enhanced biochemical potency.

-	~~The entry 4r68 is ON HOLD until Paper Publication~~	+	Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.,Labadie S, Dragovich PS, Chen J, Fauber BP, Boggs J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Ho Q, Lai KW, Ma S, Malek S, Peterson D, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A Bioorg Med Chem Lett. 2014 Nov 10;25(1):75-82. doi: 10.1016/j.bmcl.2014.11.008. PMID:25466195<ref>PMID:25466195</ref>

-	~~Authors~~: Eigenbrot, C., Ultsch, M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Lactate Dehydrogenase in complex with inhibitor compound 31~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Eigenbrot, C]]
		+	[[Category: Ultsch, M]]
		+	[[Category: Nicotinamide adenine dinucleaotide]]
		+	[[Category: Oxidoreductase]]

OCA at 13:23, 10 December 2014

2014-12-10T13:23:22Z

←Older revision		Revision as of 13:23, 10 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4r68 is ON HOLD	+	The entry 4r68 is ON HOLD until Paper Publication

	Authors: Eigenbrot, C., Ultsch, M.		Authors: Eigenbrot, C., Ultsch, M.

	Description: Lactate Dehydrogenase in complex with inhibitor compound 31		Description: Lactate Dehydrogenase in complex with inhibitor compound 31

OCA: Protected "4r68" [edit=sysop:move=sysop]

2014-09-04T04:16:26Z

Protected "4r68" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 4 September 2014

OCA: New page: '''Unreleased structure''' The entry 4r68 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase in complex with inhibitor compound 31

2014-09-04T04:16:24Z

New page: '''Unreleased structure''' The entry 4r68 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase in complex with inhibitor compound 31

New page

'''Unreleased structure'''

The entry 4r68 is ON HOLD

Authors: Eigenbrot, C., Ultsch, M.

Description: Lactate Dehydrogenase in complex with inhibitor compound 31