4rbs - Revision history

OCA at 17:47, 20 September 2023

2023-09-20T17:47:16Z

←Older revision		Revision as of 17:47, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.405Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:49, 2 March 2023

2023-03-02T06:49:09Z

←Older revision		Revision as of 06:49, 2 March 2023
Line 3:		Line 3:
	<StructureSection load='4rbs' size='340' side='right'caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='4rbs' size='340' side='right'caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [~~http~~://pdbe.org/4rbs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.	+	[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

	==See Also==		==See Also==
Line 17:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Babnigg, G]]	+	[[Category: Babnigg G]]
-	[[Category: Jedrzejczak, R]]	+	[[Category: Jedrzejczak R]]
-	[[Category: Joachimiak, A]]	+	[[Category: Joachimiak A]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Sacchettini J]]
-	~~[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors~~]]	+	[[Category: Tesar C]]
-	[[Category: Sacchettini, J]]	+
-	[[Category: Tesar, C]]	+
-	~~[[Category: Alpha-beta-beta-alpha sandwich]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mcsg]]~~	+
-	~~[[Category: Mtbi]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor~~]]	+

OCA at 09:46, 1 May 2019

2019-05-01T09:46:35Z

←Older revision		Revision as of 09:46, 1 May 2019
Line 1:		Line 1:

	==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==		==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==
-	<StructureSection load='4rbs' size='340' side='right' caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>	+	<StructureSection load='4rbs' size='340' side='right'caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RBS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://pdbe.org/4rbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://pdbe.org/4rbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>
Line 13:		Line 14:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
	[[Category: Jedrzejczak, R]]		[[Category: Jedrzejczak, R]]

OCA at 22:49, 4 August 2016

2016-08-04T22:49:51Z

←Older revision		Revision as of 22:49, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==		==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==
	<StructureSection load='4rbs' size='340' side='right' caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='4rbs' size='340' side='right' caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://pdbe.org/4rbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.		[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:23, 24 December 2014

2014-12-24T20:23:50Z

←Older revision		Revision as of 20:23, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:14, 26 November 2014

2014-11-26T08:14:11Z

←Older revision		Revision as of 08:14, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==
-		+	<StructureSection load='4rbs' size='340' side='right' caption='[[4rbs]], [[Resolution\|resolution]] 2.41Å' scene=''>
-	~~The entry~~ 4rbs is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RBS FirstGlance]. <br>
-	~~Authors~~: ~~Kim~~, Y., ~~Tesar~~, C., ~~Jedrzejczak~~, R., ~~Babnigg~~, G., ~~Sacchettini~~, J., Joachimiak, A., ~~Midwest Center for~~ Structural ~~Genomics (MCSG)~~, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors ~~(MTBI)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rkj\|3rkj]], [[3rkk\|3rkk]], [[3sbl\|3sbl]], [[3sfp\|3sfp]], [[3srx\|3srx]], [[4gyq\|4gyq]], [[4h0d\|4h0d]], [[4hky\|4hky]], [[4hl1\|4hl1]], [[4gyu\|4gyu]], [[4hl2\|4hl2]], [[4ram\|4ram]], [[4raw\|4raw]]</td></tr>
-	~~Description~~: ~~Crystal Structure of New Delhi Metallo~~-beta-~~Lactamase~~-~~1 in the Complex with Hydrolyzed Meropenem~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [http://www.ebi.ac.uk/pdbsum/4rbs PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Babnigg, G]]
		+	[[Category: Jedrzejczak, R]]
		+	[[Category: Joachimiak, A]]
		+	[[Category: Kim, Y]]
		+	[[Category: Structural genomic]]
		+	[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
		+	[[Category: Sacchettini, J]]
		+	[[Category: Tesar, C]]
		+	[[Category: Alpha-beta-beta-alpha sandwich]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mcsg]]
		+	[[Category: Mtbi]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]

OCA: Protected "4rbs" [edit=sysop:move=sysop]

2014-09-24T08:31:28Z

Protected "4rbs" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:31, 24 September 2014

OCA: New page: '''Unreleased structure''' The entry 4rbs is ON HOLD Authors: Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (...

2014-09-24T08:31:27Z

New page: '''Unreleased structure''' The entry 4rbs is ON HOLD Authors: Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (...

New page

'''Unreleased structure'''

The entry 4rbs is ON HOLD

Authors: Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)

Description: Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem