4rg3 - Revision history

OCA at 17:49, 20 September 2023

2023-09-20T17:49:46Z

←Older revision		Revision as of 17:49, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._HI-31 Rhodococcus sp. HI-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._HI-31 Rhodococcus sp. HI-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [https://pdbe.org/4rg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [https://pdbe.org/4rg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:54, 2 March 2023

2023-03-02T06:54:12Z

←Older revision		Revision as of 06:54, 2 March 2023
Line 1:		Line 1:

	==Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation==		==Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation==
-	<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='4rg3' size='340' side='right'caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rhodococcus_sp.~~_hi~~-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._HI-31 Rhodococcus sp. HI-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [https://pdbe.org/4rg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [https://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [~~http~~://pdbe.org/4rg3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C0STX7_9NOCA C0STX7_9NOCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4rg3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4rg3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyclohexanone monooxygenase~~]]	+	[[Category: Large Structures]]
-	[[Category: Rhodococcus sp. hi-31]]	+	[[Category: Rhodococcus sp. HI-31]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Yachnin~~, B J]]~~	+	[[Category: Yachnin BJ]]
-	~~[[Category: Baeyer-villiger monooxygenase]]~~	+
-	~~[[Category: Baeyer-villiger oxidation]]~~	+
-	~~[[Category: Biocatalysis]]~~	+
-	~~[[Category: Cyclohexanone]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Green chemistry]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxygen]]~~	+
-	~~[[Category: Protein engineering]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 09:05, 22 November 2017

2017-11-22T09:05:11Z

←Older revision		Revision as of 09:05, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._hi-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [http://pdbe.org/4rg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [http://pdbe.org/4rg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
		+	[[Category: Rhodococcus sp. hi-31]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Yachnin, B J]]		[[Category: Yachnin, B J]]

OCA at 12:55, 11 August 2016

2016-08-11T12:55:59Z

←Older revision		Revision as of 12:55, 11 August 2016
Line 1:		Line 1:
		+
	==Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation==		==Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation==
	<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [http://pdbe.org/4rg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rg3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rg3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 14 January 2015

2015-01-14T07:33:17Z

←Older revision		Revision as of 07:33, 14 January 2015
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Yachnin, B J.]]	+	[[Category: Yachnin, B J]]
	[[Category: Baeyer-villiger monooxygenase]]		[[Category: Baeyer-villiger monooxygenase]]
	[[Category: Baeyer-villiger oxidation]]		[[Category: Baeyer-villiger oxidation]]

OCA at 10:41, 20 October 2014

2014-10-20T10:41:32Z

←Older revision		Revision as of 10:41, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation==
		+	<StructureSection load='4rg3' size='340' side='right' caption='[[4rg3]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4rg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=ECE:CAPROLACTONE'>ECE</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwf\|3gwf]], [[3gwd\|3gwd]], [[3ucl\|3ucl]], [[4rg4\|4rg4]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Baeyer-Villiger monooxygenases (BVMOs) are microbial enzymes that catalyze the synthetically useful Baeyer-Villiger oxidation reaction. The available BVMO crystal structures all lack a substrate or product bound in a position that would determine the substrate specificity and stereospecificity of the enzyme. Here, we report two crystal structures of cyclohexanone monooxygenase (CHMO) with its product, epsilon-caprolactone, bound: the CHMOTight and CHMOLoose structures. The CHMOTight structure represents the enzyme state in which substrate acceptance and stereospecificity is determined, providing a foundation for engineering BVMOs with altered substrate spectra and/or stereospecificity. The CHMOLoose structure is the first structure where the product is solvent accessible. This structure represents the enzyme state upon binding and release of the substrate and product. In addition, the role of the invariant Arg329 in chaperoning the substrate/product during the catalytic cycle is highlighted. Overall, these data provide a structural framework for the engineering of BVMOs with altered substrate spectra and/or stereospecificity.

-	~~The entry 4rg3 is ON HOLD~~	+	Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis.,Yachnin BJ, McEvoy MB, MacCuish RJ, Morley KL, Lau PC, Berghuis AM ACS Chem Biol. 2014 Sep 29. PMID:25265531<ref>PMID:25265531</ref>

-	~~Authors: Yachnin~~, B.J., Berghuis, A.M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Epsilon~~-~~caprolactone-bound crystal structure of cyclohexanone~~ monooxygenase ~~in the Tight conformation~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cyclohexanone monooxygenase]]
		+	[[Category: Berghuis, A M.]]
		+	[[Category: Yachnin, B J.]]
		+	[[Category: Baeyer-villiger monooxygenase]]
		+	[[Category: Baeyer-villiger oxidation]]
		+	[[Category: Biocatalysis]]
		+	[[Category: Cyclohexanone]]
		+	[[Category: Fad]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Green chemistry]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxygen]]
		+	[[Category: Protein engineering]]
		+	[[Category: Rossmann fold]]

OCA: Protected "4rg3" [edit=sysop:move=sysop]

2014-10-08T06:33:35Z

Protected "4rg3" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:33, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4rg3 is ON HOLD Authors: Yachnin, B.J., Berghuis, A.M. Description: Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in ...

2014-10-08T06:33:34Z

New page: '''Unreleased structure''' The entry 4rg3 is ON HOLD Authors: Yachnin, B.J., Berghuis, A.M. Description: Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in ...

New page

'''Unreleased structure'''

The entry 4rg3 is ON HOLD

Authors: Yachnin, B.J., Berghuis, A.M.

Description: Epsilon-caprolactone-bound crystal structure of cyclohexanone monooxygenase in the Tight conformation