4rhs - Revision history

OCA at 06:57, 2 March 2023

2023-03-02T06:57:19Z

←Older revision		Revision as of 06:57, 2 March 2023
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	<StructureSection load='4rhs' size='340' side='right'caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4rhs' size='340' side='right'caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rhs]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4RHS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rhs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [https://pdbe.org/4rhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [https://www.ebi.ac.uk/pdbsum/4rhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhs ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [~~http~~://pdbe.org/4rhs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4rhs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8Z6A3_SALTI Q8Z6A3_SALTI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus typhi schroeter 1886]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Galan, J~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
-	[[Category: ~~Gao, X]]~~	+	[[Category: Galan J]]
-	~~[[Category: Wang,~~ J]]	+	[[Category: Gao X]]
-	[[Category: ~~Sugar~~]]	+	[[Category: Wang J]]
-	[[Category: ~~Sugar binding]]~~	+
-	~~[[Category: Sugar binding motif]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 09:59, 1 May 2019

2019-05-01T09:59:14Z

←Older revision		Revision as of 09:59, 1 May 2019
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	==Crystal structure of GD2 bound PltB==		==Crystal structure of GD2 bound PltB==
-	<StructureSection load='4rhs' size='340' side='right' caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='4rhs' size='340' side='right'caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4rhs]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4rhs]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://pdbe.org/4rhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://pdbe.org/4rhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhs ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus typhi schroeter 1886]]
		+	[[Category: Large Structures]]
	[[Category: Galan, J]]		[[Category: Galan, J]]
	[[Category: Gao, X]]		[[Category: Gao, X]]

OCA at 08:23, 5 August 2016

2016-08-05T08:23:48Z

←Older revision		Revision as of 08:23, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of GD2 bound PltB==		==Crystal structure of GD2 bound PltB==
	<StructureSection load='4rhs' size='340' side='right' caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4rhs' size='340' side='right' caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://pdbe.org/4rhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4rhs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 17 December 2014

2014-12-17T10:03:43Z

←Older revision		Revision as of 10:03, 17 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to terminally sialylated glycans on surface glycoproteins. Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc). Here, we report that typhoid toxin binds to and is toxic toward cells expressing glycans terminated in Neu5Ac (expressed by humans) over glycans terminated in Neu5Gc (expressed by other mammals). Mice constitutively expressing CMAH thus displaying Neu5Gc in all tissues are resistant to typhoid toxin. The atomic structure of typhoid toxin bound to Neu5Ac reveals the structural bases for its binding specificity. These findings provide insight into the molecular bases for Salmonella Typhi's host specificity and may help the development of therapies for typhoid fever.
		+
		+	Host adaptation of a bacterial toxin from the human pathogen salmonella typhi.,Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galan JE, Varki A Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057. PMID:25480294<ref>PMID:25480294</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Galan, J.]]	+	[[Category: Galan, J]]
-	[[Category: Gao, X.]]	+	[[Category: Gao, X]]
-	[[Category: Wang, J.]]	+	[[Category: Wang, J]]
	[[Category: Sugar]]		[[Category: Sugar]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Sugar binding motif]]		[[Category: Sugar binding motif]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 11:31, 29 October 2014

2014-10-29T11:31:56Z

←Older revision		Revision as of 11:31, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of GD2 bound PltB==
-		+	<StructureSection load='4rhs' size='340' side='right' caption='[[4rhs]], [[Resolution\|resolution]] 1.92Å' scene=''>
-	~~The entry~~ 4rhs is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4rhs]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHS FirstGlance]. <br>
-	~~Authors~~: ~~Gao~~, X., ~~Wang~~, J., Galan, J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~Description~~: ~~Crystal structure of GD2 bound PltB~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k6l\|4k6l]], [[4rhr\|4rhr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rhs RCSB], [http://www.ebi.ac.uk/pdbsum/4rhs PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Galan, J.]]
		+	[[Category: Gao, X.]]
		+	[[Category: Wang, J.]]
		+	[[Category: Sugar]]
		+	[[Category: Sugar binding]]
		+	[[Category: Sugar binding motif]]
		+	[[Category: Sugar binding protein]]

OCA at 09:28, 20 October 2014

2014-10-20T09:28:49Z

←Older revision		Revision as of 09:28, 20 October 2014
Line 3:		Line 3:
	The entry 4rhs is ON HOLD		The entry 4rhs is ON HOLD

-	Authors: Gao,~~Xiang~~, Wang,~~Jiawei~~ , Galan,~~Jorge~~	+	Authors: Gao, X., Wang, J., Galan, J.

-	Description: ~~crystal~~ structure of GD2 bound PltB	+	Description: Crystal structure of GD2 bound PltB

OCA: Protected "4rhs" [edit=sysop:move=sysop]

2014-10-08T06:36:07Z

Protected "4rhs" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 8 October 2014

OCA: New page: '''Unreleased structure''' The entry 4rhs is ON HOLD Authors: Gao,Xiang, Wang,Jiawei , Galan,Jorge Description: crystal structure of GD2 bound PltB

2014-10-08T06:36:06Z

New page: '''Unreleased structure''' The entry 4rhs is ON HOLD Authors: Gao,Xiang, Wang,Jiawei , Galan,Jorge Description: crystal structure of GD2 bound PltB

New page

'''Unreleased structure'''

The entry 4rhs is ON HOLD

Authors: Gao,Xiang, Wang,Jiawei , Galan,Jorge

Description: crystal structure of GD2 bound PltB