4s0s - Revision history

OCA at 12:57, 1 March 2024

2024-03-01T12:57:41Z

←Older revision		Revision as of 12:57, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [https://pdbe.org/4s0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [https://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [https://pdbe.org/4s0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [https://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>		[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics and regulates expression of several drug metabolizing enzymes and transporters. We have generated "Adnectins", derived from 10th fibronectin type III domain (10Fn3), that target the PXR ligand binding domain (LBD) interactions with the steroid receptor co-activator-1 (SRC-1) peptide, displacing SRC-1 binding. Adnectins are structurally homologous to the immunoglobulin superfamily. Three different co-crystal structures of PXR LBD with Adnectin-1 and CCR1 (CC chemokine receptor-1) antagonist Compound-1 were determined. This structural information was used to modulate PXR affinity for a related CCR1 antagonist compound that entered into clinical trials for rheumatoid arthritis. The structures of PXR with Adnectin-1 reveal specificity of Adnectin-1 in not only targeting the interface of the SRC-1 interactions but also engaging the same set of residues that are involved in binding of SRC-1 to PXR. Substituting SRC-1 with Adnectin-1 does not alter the binding conformation of Compound-1 in the ligand binding pocket. The structure also reveals the possibility of using Adnectins as crystallization chaperones to generate structures of PXR with compounds of interest.
-
-	Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.,Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J Jr J Mol Biol. 2015 Jan 8. pii: S0022-2836(15)00002-9. doi:, 10.1016/j.jmb.2014.12.022. PMID:25579995<ref>PMID:25579995</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4s0s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Pregnane X receptor\|Pregnane X receptor]]	+	*[[Pregnane X receptor 3D structures\|Pregnane X receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:38, 15 March 2023

2023-03-15T10:38:00Z

←Older revision		Revision as of 10:38, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4s0s' size='340' side='right'caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4s0s' size='340' side='right'caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4S0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0S FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [https://pdbe.org/4s0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [https://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR1I2, PXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [~~http~~://pdbe.org/4s0s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN]] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>	+	[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Khan~~, J A]]~~	+	[[Category: Khan JA]]
-	~~[[Category: Activation function]]~~	+
-	~~[[Category: Af]]~~	+
-	~~[[Category: Ccr1]]~~	+
-	~~[[Category: Chemokine receptor-1]]~~	+
-	~~[[Category: Cyp]]~~	+
-	~~[[Category: Cytochrome p450]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Mdr1]]~~	+
-	~~[[Category: Multi-drug resistance gene-1]]~~	+
-	~~[[Category: Nr]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Pregnane x receptor]]~~	+
-	~~[[Category: Pxr]]~~	+
-	~~[[Category: Steroid receptor coactivator-1~~]]	+

OCA at 09:35, 1 May 2019

2019-05-01T09:35:45Z

←Older revision		Revision as of 09:35, 1 May 2019
Line 1:		Line 1:

	==STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1==		==STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1==
-	<StructureSection load='4s0s' size='340' side='right' caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4s0s' size='340' side='right'caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR1I2, PXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [http://pdbe.org/4s0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [http://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [http://pdbe.org/4s0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [http://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4s0s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4s0s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pregnane X receptor\|Pregnane X receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Khan, J A]]		[[Category: Khan, J A]]
	[[Category: Activation function]]		[[Category: Activation function]]

OCA at 01:07, 19 January 2017

2017-01-19T01:07:51Z

←Older revision		Revision as of 01:07, 19 January 2017
Line 1:		Line 1:
		+
	==STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1==		==STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1==
	<StructureSection load='4s0s' size='340' side='right' caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4s0s' size='340' side='right' caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [http://www.ebi.ac.uk/pdbsum/4s0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [http://pdbe.org/4s0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [http://www.ebi.ac.uk/pdbsum/4s0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4s0s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:46, 12 February 2015

2015-02-12T11:46:44Z

←Older revision		Revision as of 11:46, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1==
		+	<StructureSection load='4s0s' size='340' side='right' caption='[[4s0s]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4s0s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0S FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xhd\|1xhd]], [[4s0t\|4s0t]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s0s RCSB], [http://www.ebi.ac.uk/pdbsum/4s0s PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN]] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics and regulates expression of several drug metabolizing enzymes and transporters. We have generated "Adnectins", derived from 10th fibronectin type III domain (10Fn3), that target the PXR ligand binding domain (LBD) interactions with the steroid receptor co-activator-1 (SRC-1) peptide, displacing SRC-1 binding. Adnectins are structurally homologous to the immunoglobulin superfamily. Three different co-crystal structures of PXR LBD with Adnectin-1 and CCR1 (CC chemokine receptor-1) antagonist Compound-1 were determined. This structural information was used to modulate PXR affinity for a related CCR1 antagonist compound that entered into clinical trials for rheumatoid arthritis. The structures of PXR with Adnectin-1 reveal specificity of Adnectin-1 in not only targeting the interface of the SRC-1 interactions but also engaging the same set of residues that are involved in binding of SRC-1 to PXR. Substituting SRC-1 with Adnectin-1 does not alter the binding conformation of Compound-1 in the ligand binding pocket. The structure also reveals the possibility of using Adnectins as crystallization chaperones to generate structures of PXR with compounds of interest.

-	~~The entry 4s0s is ON HOLD~~	+	Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.,Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J Jr J Mol Biol. 2015 Jan 8. pii: S0022-2836(15)00002-9. doi:, 10.1016/j.jmb.2014.12.022. PMID:25579995<ref>PMID:25579995</ref>

-	~~Authors~~: Khan, J.A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN~~-1	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Khan, J.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Khan, J A]]
		+	[[Category: Activation function]]
		+	[[Category: Af]]
		+	[[Category: Ccr1]]
		+	[[Category: Chemokine receptor-1]]
		+	[[Category: Cyp]]
		+	[[Category: Cytochrome p450]]
		+	[[Category: Immune system]]
		+	[[Category: Ligand binding domain]]
		+	[[Category: Mdr1]]
		+	[[Category: Multi-drug resistance gene-1]]
		+	[[Category: Nr]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Pregnane x receptor]]
		+	[[Category: Pxr]]
		+	[[Category: Steroid receptor coactivator-1]]

OCA at 12:50, 7 February 2015

2015-02-07T12:50:40Z

←Older revision		Revision as of 12:50, 7 February 2015
Line 5:		Line 5:
	Authors: Khan, J.A.		Authors: Khan, J.A.

-	Description: STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN ~~WITH~~ ADNECTIN-1	+	Description: STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Khan, J.A]]		[[Category: Khan, J.A]]

OCA: Protected "4s0s" [edit=sysop:move=sysop]

2015-01-14T10:58:30Z

Protected "4s0s" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 14 January 2015

OCA: New page: '''Unreleased structure''' The entry 4s0s is ON HOLD Authors: Khan, J.A. Description: STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH ADNECTIN-1 [[Category: Unrelease...

2015-01-14T10:58:29Z

New page: '''Unreleased structure''' The entry 4s0s is ON HOLD Authors: Khan, J.A. Description: STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH ADNECTIN-1 [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 4s0s is ON HOLD

Authors: Khan, J.A.

Description: STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH ADNECTIN-1
[[Category: Unreleased Structures]]
[[Category: Khan, J.A]]