4s1r - Revision history

OCA at 18:01, 20 September 2023

2023-09-20T18:01:09Z

←Older revision		Revision as of 18:01, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1R FirstGlance]. <br>		<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.214Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [https://pdbe.org/4s1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [https://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [https://pdbe.org/4s1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [https://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:39, 15 March 2023

2023-03-15T10:39:20Z

←Older revision		Revision as of 10:39, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4s1r' size='340' side='right'caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='4s1r' size='340' side='right'caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~] and [https://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4s1q\|4s1q]], [[4s1s\|4s1s]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIV-1 Env ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1]), Heavy chain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Light chain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [https://pdbe.org/4s1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [https://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [https://pdbe.org/4s1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [https://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0M3KKW9_9HIV1 A0A0M3KKW9_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kwon~~, Y D~~]]	+	[[Category: Kwon YD]]
-	[[Category: Kwong~~, P D~~]]	+	[[Category: Kwong PD]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	[[Category: Zhang, B]]	+	[[Category: Zhang B]]
-	~~[[Category: Antibody maturation]]~~	+
-	~~[[Category: Evolutionary rate]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Neutralizing antibody]]~~	+
-	~~[[Category: Viral protein-immune system-inhibitor complex]]~~	+
-	~~[[Category: Vrc01-lineage~~]]	+

OCA at 14:40, 2 June 2021

2021-06-02T14:40:46Z

←Older revision		Revision as of 14:40, 2 June 2021
Line 3:		Line 3:
	<StructureSection load='4s1r' size='340' side='right'caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='4s1r' size='340' side='right'caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9hiv1 9hiv1] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4S1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4s1q\|4s1q]], [[4s1s\|4s1s]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIV-1 Env ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1]), Heavy chain ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Light chain ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIV-1 Env ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1]), Heavy chain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Light chain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [~~http~~://pdbe.org/4s1r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [https://pdbe.org/4s1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [https://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[Gp120\|Gp120]]	+	*[[Gp120 3D structures\|Gp120 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:07, 1 May 2019

2019-05-01T10:07:17Z

←Older revision		Revision as of 10:07, 1 May 2019
Line 1:		Line 1:

	==Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core==		==Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core==
-	<StructureSection load='4s1r' size='340' side='right' caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='4s1r' size='340' side='right'caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIV-1 Env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1]), Heavy chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Light chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [http://pdbe.org/4s1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [http://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [http://pdbe.org/4s1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [http://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Gp120\|Gp120]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kwon, Y D]]		[[Category: Kwon, Y D]]
	[[Category: Kwong, P D]]		[[Category: Kwong, P D]]

OCA at 02:00, 10 March 2017

2017-03-10T02:00:19Z

←Older revision		Revision as of 02:00, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core==		==Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core==
	<StructureSection load='4s1r' size='340' side='right' caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='4s1r' size='340' side='right' caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [http://www.ebi.ac.uk/pdbsum/4s1r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [http://pdbe.org/4s1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [http://www.ebi.ac.uk/pdbsum/4s1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4s1r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:49, 22 April 2015

2015-04-22T12:49:34Z

←Older revision		Revision as of 12:49, 22 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core==
		+	<StructureSection load='4s1r' size='340' side='right' caption='[[4s1r]], [[Resolution\|resolution]] 3.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4s1r]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4s1q\|4s1q]], [[4s1s\|4s1s]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s1r RCSB], [http://www.ebi.ac.uk/pdbsum/4s1r PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HIV-1-neutralizing antibodies develop in most HIV-1-infected individuals, although highly effective antibodies are generally observed only after years of chronic infection. Here, we characterize the rate of maturation and extent of diversity for the lineage that produced the broadly neutralizing antibody VRC01 through longitudinal sampling of peripheral B cell transcripts over 15 years and co-crystal structures of lineage members. Next-generation sequencing identified VRC01-lineage transcripts, which encompassed diverse antibodies organized into distinct phylogenetic clades. Prevalent clades maintained characteristic features of antigen recognition, though each evolved binding loops and disulfides that formed distinct recognition surfaces. Over the course of the study period, VRC01-lineage clades showed continuous evolution, with rates of approximately 2 substitutions per 100 nucleotides per year, comparable to that of HIV-1 evolution. This high rate of antibody evolution provides a mechanism by which antibody lineages can achieve extraordinary diversity and, over years of chronic infection, develop effective HIV-1 neutralization.

-	~~The entry 4s1r is ON HOLD until Paper Publication~~	+	Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.,Wu X, Zhang Z, Schramm CA, Joyce MG, Do Kwon Y, Zhou T, Sheng Z, Zhang B, O'Dell S, McKee K, Georgiev IS, Chuang GY, Longo NS, Lynch RM, Saunders KO, Soto C, Srivatsan S, Yang Y, Bailer RT, Louder MK, Mullikin JC, Connors M, Kwong PD, Mascola JR, Shapiro L Cell. 2015 Apr 8. pii: S0092-8674(15)00257-3. doi: 10.1016/j.cell.2015.03.004. PMID:25865483<ref>PMID:25865483</ref>

-	~~Authors: Kwon~~, Y.D.~~, Yang, Y., Zhang, B~~., Kwong, P.D.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with Clade A/E HIV-1 gp120 core~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kwon, Y D]]
		+	[[Category: Kwong, P D]]
		+	[[Category: Yang, Y]]
	[[Category: Zhang, B]]		[[Category: Zhang, B]]
-	[[Category: ~~Yang, Y~~]]	+	[[Category: Antibody maturation]]
-	[[Category: ~~Kwon, Y.D~~]]	+	[[Category: Evolutionary rate]]
-	[[Category: ~~Kwong, P.D~~]]	+	[[Category: Hiv-1]]
		+	[[Category: Neutralizing antibody]]
		+	[[Category: Viral protein-immune system-inhibitor complex]]
		+	[[Category: Vrc01-lineage]]

OCA at 07:20, 8 April 2015

2015-04-08T07:20:56Z

←Older revision		Revision as of 07:20, 8 April 2015
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	Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D.		Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D.

-	Description: Crystal structure of a VRC01-lineage antibody,45-VRC01.H08.F-117225, in complex with gp120	+	Description: Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with Clade A/E HIV-1 gp120 core
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhang, B]]		[[Category: Zhang, B]]

OCA at 08:04, 4 March 2015

2015-03-04T08:04:01Z

←Older revision		Revision as of 08:04, 4 March 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4s1r is ON HOLD	+	The entry 4s1r is ON HOLD until Paper Publication

	Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D.		Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D.

OCA: Protected "4s1r" [edit=sysop:move=sysop]

2015-01-21T14:11:15Z

Protected "4s1r" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:11, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4s1r is ON HOLD Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D. Description: Crystal structure of a VRC01-lineage antibody,45-VRC01.H08.F-117...

2015-01-21T14:11:14Z

New page: '''Unreleased structure''' The entry 4s1r is ON HOLD Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D. Description: Crystal structure of a VRC01-lineage antibody,45-VRC01.H08.F-117...

New page

'''Unreleased structure'''

The entry 4s1r is ON HOLD

Authors: Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D.

Description: Crystal structure of a VRC01-lineage antibody,45-VRC01.H08.F-117225, in complex with gp120
[[Category: Unreleased Structures]]
[[Category: Zhang, B]]
[[Category: Yang, Y]]
[[Category: Kwon, Y.D]]
[[Category: Kwong, P.D]]