4s1x - Revision history

OCA at 10:39, 15 March 2023

2023-03-15T10:39:29Z

←Older revision		Revision as of 10:39, 15 March 2023
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	<StructureSection load='4s1x' size='340' side='right'caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4s1x' size='340' side='right'caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4s1x]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4S1X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4s1x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1x OCA], [https://pdbe.org/4s1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1x RCSB], [https://www.ebi.ac.uk/pdbsum/4s1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1x ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oxm\|4oxm]], [[4p67\|4p67]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4s1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1x OCA], [~~http~~://pdbe.org/4s1x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4s1x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4s1x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1x ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8TXX2_9ORTO A8TXX2_9ORTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Almo, S C~~]]	+	[[Category: Unidentified influenza virus]]
-	[[Category: ~~Higgins, C D~~]]	+	[[Category: Almo SC]]
-	[[Category: ~~Lai, J R~~]]	+	[[Category: Higgins CD]]
-	[[Category: ~~Malashkevich, V N~~]]	+	[[Category: Lai JR]]
-	[[Category: ~~Gp2 ectodomain]]~~	+	[[Category: Malashkevich VN]]
-	~~[[Category: Marburg virus]]~~	+
-	~~[[Category: Post-fusion conformation]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:26, 1 May 2019

2019-05-01T10:26:58Z

←Older revision		Revision as of 10:26, 1 May 2019
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	==Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter==		==Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter==
-	<StructureSection load='4s1x' size='340' side='right' caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4s1x' size='340' side='right'caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4s1x]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4s1x]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1X FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Higgins, C D]]		[[Category: Higgins, C D]]

OCA at 02:01, 11 March 2017

2017-03-11T02:01:48Z

←Older revision		Revision as of 02:01, 11 March 2017
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		+
	==Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter==		==Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter==
	<StructureSection load='4s1x' size='340' side='right' caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4s1x' size='340' side='right' caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oxm\|4oxm]], [[4p67\|4p67]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oxm\|4oxm]], [[4p67\|4p67]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s1x RCSB], [http://www.ebi.ac.uk/pdbsum/4s1x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1x OCA], [http://pdbe.org/4s1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1x RCSB], [http://www.ebi.ac.uk/pdbsum/4s1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1x ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4s1x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:28, 10 June 2015

2015-06-10T07:28:57Z

←Older revision		Revision as of 07:28, 10 June 2015
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:09, 1 April 2015

2015-04-01T13:09:27Z

←Older revision		Revision as of 13:09, 1 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter==
		+	<StructureSection load='4s1x' size='340' side='right' caption='[[4s1x]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4s1x]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oxm\|4oxm]], [[4p67\|4p67]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s1x RCSB], [http://www.ebi.ac.uk/pdbsum/4s1x PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coiled-coil is one of the most ubiquitous and well studied protein structural motifs. Significant effort has been devoted to dissecting subtle variations of the typical heptad repeat sequence pattern that can designate larger topological features such as relative alpha-helical orientation and oligomer size. Here we report the X-ray structure of a model coiled-coil peptide, HA2-Del-L2seM, which forms an unanticipated core antiparallel dimer with potential sites for discrete higher-order multimerization (trimer or tetramer). In the X-ray structure, a third, partially-ordered alpha-helix is weakly associated with the antiparallel dimer and analytical ultracentrifugation experiments indicate the peptide forms a well-defined tetramer in solution. The HA2-Del-L2seM sequence is closely related to a parent model peptide, HA2-Del, which we previously reported adopts a parallel trimer; HA2-Del-L2seM differs by only hydrophobic leucine to selenomethione mutations and thus this subtle difference is sufficient to switch both relative alpha-helical topology and number of alpha-helices participating in the coiled-coil. Comparison of the X-ray structures of HA2-Del-L2seM (reported here) with the HA2-Del parent (reported previously) reveals novel interactions involving the selenomethionine residues that promote antiparallel coiled-coil configuration and preclude parallel trimer formation. These novel atomic insights are instructive for understanding subtle features that can affect coiled-coil topology and provide additional information for design of antiparallel coiled-coils. This article is protected by copyright. All rights reserved.

-	~~The entry 4s1x is ON HOLD~~	+	A Switch from Parallel to Antiparallel Strand Orientation in a Coiled-Coil X-Ray Structure via Two Core Hydrophobic Mutations.,Malashkevich VN, Higgins CD, Almo SC, Lai JR Biopolymers. 2015 Mar 6. doi: 10.1002/bip.22631. PMID:25753192<ref>PMID:25753192</ref>

-	~~Authors: Malashkevich~~, V.N.~~, Higgins, C~~.~~D., Lai, J.R.,~~ Almo, S.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of HA2-Del-L2seM~~, ~~Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Malashkevich, V.N]]	+	__TOC__
-	[[Category: ~~Almo, S.C~~]]	+	</StructureSection>
-	[[Category: ~~Higgins, C.D~~]]	+	[[Category: Almo, S C]]
-	[[Category: ~~Lai, J.R~~]]	+	[[Category: Higgins, C D]]
		+	[[Category: Lai, J R]]
		+	[[Category: Malashkevich, V N]]
		+	[[Category: Gp2 ectodomain]]
		+	[[Category: Marburg virus]]
		+	[[Category: Post-fusion conformation]]
		+	[[Category: Viral protein]]

OCA at 08:04, 4 March 2015

2015-03-04T08:04:15Z

←Older revision		Revision as of 08:04, 4 March 2015
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	The entry 4s1x is ON HOLD		The entry 4s1x is ON HOLD

-	Authors: V.N.~~Malashkevich~~, C. D. ~~Higgins~~, J.R. ~~Lai~~, S.C.~~Almo~~	+	Authors: Malashkevich, V.N., Higgins, C.D., Lai, J.R., Almo, S.C.

-	Description: ~~CRYSTAL STRUCTURE OF~~ HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter	+	Description: Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: V.N.~~Malashkevich~~, C. D~~. Higgins~~, J.R~~. Lai, S.C.Almo~~]]	+	[[Category: Malashkevich, V.N]]
		+	[[Category: Almo, S.C]]
		+	[[Category: Higgins, C.D]]
		+	[[Category: Lai, J.R]]

OCA: Protected "4s1x" [edit=sysop:move=sysop]

2015-01-21T14:11:41Z

Protected "4s1x" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:11, 21 January 2015

OCA: New page: '''Unreleased structure''' The entry 4s1x is ON HOLD Authors: V.N.Malashkevich, C. D. Higgins, J.R. Lai, S.C.Almo Description: CRYSTAL STRUCTURE OF HA2-Del-L2seM, Central Coiled-Coil f...

2015-01-21T14:11:40Z

New page: '''Unreleased structure''' The entry 4s1x is ON HOLD Authors: V.N.Malashkevich, C. D. Higgins, J.R. Lai, S.C.Almo Description: CRYSTAL STRUCTURE OF HA2-Del-L2seM, Central Coiled-Coil f...

New page

'''Unreleased structure'''

The entry 4s1x is ON HOLD

Authors: V.N.Malashkevich, C. D. Higgins, J.R. Lai, S.C.Almo

Description: CRYSTAL STRUCTURE OF HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2 without Heptad Repeat Stutter
[[Category: Unreleased Structures]]
[[Category: V.N.Malashkevich, C. D. Higgins, J.R. Lai, S.C.Almo]]