4trf - Revision history

OCA at 00:47, 28 December 2023

2023-12-28T00:47:33Z

←Older revision		Revision as of 00:47, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [https://pdbe.org/4trf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [https://www.ebi.ac.uk/pdbsum/4trf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [https://pdbe.org/4trf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [https://www.ebi.ac.uk/pdbsum/4trf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:51, 15 March 2023

2023-03-15T10:51:56Z

←Older revision		Revision as of 10:51, 15 March 2023
Line 1:		Line 1:

	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide==		==Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide==
-	<StructureSection load='4trf' size='340' side='right' caption='[[4trf]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='4trf' size='340' side='right'caption='[[4trf]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trs\|4trs]], [[4tru\|4tru]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [https://pdbe.org/4trf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [https://www.ebi.ac.uk/pdbsum/4trf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trf ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [~~http~~://pdbe.org/4trf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4trf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4trf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4trf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4trf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lolis, E~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pantouris, G~~]]	+	[[Category: Lolis E]]
-	[[Category: ~~Active site]]~~	+	[[Category: Pantouris G]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Inhibitor isomerase]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex~~]]	+

OCA at 09:16, 22 November 2017

2017-11-22T09:16:56Z

←Older revision		Revision as of 09:16, 22 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide==		==Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide==
	<StructureSection load='4trf' size='340' side='right' caption='[[4trf]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4trf' size='340' side='right' caption='[[4trf]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trs\|4trs]], [[4tru\|4tru]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trs\|4trs]], [[4tru\|4tru]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [http://pdbe.org/4trf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [http://www.ebi.ac.uk/pdbsum/4trf PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [http://pdbe.org/4trf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [http://www.ebi.ac.uk/pdbsum/4trf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4trf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]

OCA at 14:29, 30 September 2015

2015-09-30T14:29:47Z

←Older revision		Revision as of 14:29, 30 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide==
		+	<StructureSection load='4trf' size='340' side='right' caption='[[4trf]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4trf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35J:N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE'>35J</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4trs\|4trs]], [[4tru\|4tru]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trf OCA], [http://pdbe.org/4trf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4trf RCSB], [http://www.ebi.ac.uk/pdbsum/4trf PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For more than 15 years, the tautomerase active site of macrophage migration inhibitory factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of therapeutics that block activation of its cell surface receptor, CD74. Neither the biological role of the MIF catalytic site nor the mechanistic details of CD74 activation are well understood. The inherently unstable structure of CD74 remains the biggest obstacle in structural studies with MIF for understanding the basis of CD74 activation. Using a novel approach, we elucidate the mechanistic details that control activation of CD74 by MIF surface residues and identify structural parameters of inhibitors that reduce CD74 biological activation. We also find that N-terminal mutants located deep in the catalytic site affect surface residues immediately outside the catalytic site, which are responsible for reduction of CD74 activation.

-	~~The entry 4trf is ON HOLD until Paper Publication~~	+	An Analysis of MIF Structural Features that Control Functional Activation of CD74.,Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub , 2015 Sep 10. PMID:26364929<ref>PMID:26364929</ref>

-	~~Authors: Pantouris~~, G.~~, Lolis, E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with N~~-~~(pyridin~~-~~3-ylmethyl)thioformamide~~	+	<div class="pdbe-citations 4trf" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]
		+	[[Category: Active site]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor isomerase]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]

OCA at 17:48, 24 December 2014

2014-12-24T17:48:47Z

←Older revision		Revision as of 17:48, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide		Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lolis, E]]
		+	[[Category: Pantouris, G]]

OCA at 07:31, 2 July 2014

2014-07-02T07:31:49Z

←Older revision		Revision as of 07:31, 2 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4trf is ON HOLD	+	The entry 4trf is ON HOLD until Paper Publication

	Authors: Pantouris, G., Lolis, E.		Authors: Pantouris, G., Lolis, E.

-	Description: Crystal ~~Structure~~ of Macrophage Migration Inhibitory Factor in ~~Complex~~ with N-(pyridin-3-ylmethyl)~~methanethioamide~~	+	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide

OCA: Protected "4trf" [edit=sysop:move=sysop]

2014-06-25T06:03:34Z

Protected "4trf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 25 June 2014

OCA: New page: '''Unreleased structure''' The entry 4trf is ON HOLD Authors: Pantouris, G., Lolis, E. Description: Crystal Structure of Macrophage Migration Inhibitory Factor in Complex with N-(pyrid...

2014-06-25T06:03:33Z

New page: '''Unreleased structure''' The entry 4trf is ON HOLD Authors: Pantouris, G., Lolis, E. Description: Crystal Structure of Macrophage Migration Inhibitory Factor in Complex with N-(pyrid...

New page

'''Unreleased structure'''

The entry 4trf is ON HOLD

Authors: Pantouris, G., Lolis, E.

Description: Crystal Structure of Macrophage Migration Inhibitory Factor in Complex with N-(pyridin-3-ylmethyl)methanethioamide