4twa - Revision history

OCA at 07:23, 27 September 2023

2023-09-27T07:23:48Z

←Older revision		Revision as of 07:23, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [https://pdbe.org/4twa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [https://www.ebi.ac.uk/pdbsum/4twa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [https://pdbe.org/4twa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [https://www.ebi.ac.uk/pdbsum/4twa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:59, 15 March 2023

2023-03-15T10:59:07Z

←Older revision		Revision as of 10:59, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='4twa' size='340' side='right'caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4twa' size='340' side='right'caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">proRS, PFL0670c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [https://pdbe.org/4twa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [https://www.ebi.ac.uk/pdbsum/4twa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [~~http~~://pdbe.org/4twa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4twa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SYP_PLAF7 SYP_PLAF7]] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala).<ref>PMID:14663147</ref>	+	[https://www.uniprot.org/uniprot/SYP_PLAF7 SYP_PLAF7] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala).<ref>PMID:14663147</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7]]~~	+	[[Category: Plasmodium falciparum 3D7]]
-	~~[[Category: Proline--tRNA ligase~~]]	+	[[Category: Jain V]]
-	[[Category: Jain, V]]	+	[[Category: Sharma A]]
-	[[Category: Sharma, A]]	+	[[Category: Yogavel M]]
-	[[Category: Yogavel, M]]	+
-	~~[[Category: Halofuginone]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Pr]]~~	+
-	~~[[Category: Protein translation]]~~	+
-	~~[[Category: Synthetase~~]]	+

OCA at 13:54, 10 May 2019

2019-05-10T13:54:30Z

←Older revision		Revision as of 13:54, 10 May 2019
Line 1:		Line 1:

	==Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum==		==Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum==
-	<StructureSection load='4twa' size='340' side='right' caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4twa' size='340' side='right'caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">proRS, PFL0670c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://pdbe.org/4twa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://pdbe.org/4twa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4twa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4twa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
	[[Category: Jain, V]]		[[Category: Jain, V]]
Line 29:		Line 35:
	[[Category: Halofuginone]]		[[Category: Halofuginone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
		+	[[Category: Ligase]]
	[[Category: Malaria]]		[[Category: Malaria]]
-	[[Category: Protein translation]]
	[[Category: Pr]]		[[Category: Pr]]
		+	[[Category: Protein translation]]
	[[Category: Synthetase]]		[[Category: Synthetase]]

OCA at 23:53, 4 August 2016

2016-08-04T23:53:12Z

←Older revision		Revision as of 23:53, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum==		==Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum==
	<StructureSection load='4twa' size='340' side='right' caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4twa' size='340' side='right' caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://pdbe.org/4twa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4twa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4twa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:09, 25 December 2014

2014-12-25T14:09:36Z

←Older revision		Revision as of 14:09, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYP_PLAF7 SYP_PLAF7]] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala).<ref>PMID:14663147</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:25, 3 December 2014

2014-12-03T07:25:06Z

←Older revision		Revision as of 07:25, 3 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
-	[[Category: Jain, V.]]	+	[[Category: Jain, V]]
-	[[Category: Sharma, A.]]	+	[[Category: Sharma, A]]
-	[[Category: Yogavel, M.]]	+	[[Category: Yogavel, M]]
	[[Category: Halofuginone]]		[[Category: Halofuginone]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]

OCA at 08:57, 13 August 2014

2014-08-13T08:57:08Z

←Older revision		Revision as of 08:57, 13 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum==
		+	<StructureSection load='4twa' size='340' side='right' caption='[[4twa]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4twa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twa RCSB], [http://www.ebi.ac.uk/pdbsum/4twa PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoacyl-tRNA synthetases (aaRSs) drive protein translation in cells and hence these are essential enzymes across life. Inhibition of these enzymes can halt growth of an organism by stalling protein translation. Therefore, small molecule targeting of aaRS active sites is an attractive avenue from the perspective of developing anti-infectives. Febrifugine and its derivatives like halofuginone (HF) are known to inhibit prolyl-tRNA synthetase of malaria parasite Plasmodium falciparum. Here, we present functional and crystallographic data on P. falciparum prolyl-tRNA synthetase (PfPRS). Using immunofluorescence data, we show that PfPRS is exclusively resident in the parasite cytoplasm within asexual blood stage parasites. The inhibitor HF interacts strongly with PfPRS in a non-competitive binding mode in presence or absence of ATP analog. Intriguingly, the two monomers that constitute dimeric PfPRS display significantly different conformations in their active site regions. The structural analyses presented here provide a framework for development of febrifugine derivatives that can seed development of new anti-malarials.

-	~~The entry 4twa is ON HOLD~~	+	Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.,Jain V, Kikuchi H, Oshima Y, Sharma A, Yogavel M J Struct Funct Genomics. 2014 Jul 22. PMID:25047712<ref>PMID:25047712</ref>

-	~~Authors~~: Jain, V., Yogavel, M.~~, Sharma, A.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of Prolyl-tRNA~~ Synthetase ~~(PRS) from Plasmodium falciparum~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Proline--tRNA ligase]]
		+	[[Category: Jain, V.]]
		+	[[Category: Sharma, A.]]
		+	[[Category: Yogavel, M.]]
		+	[[Category: Halofuginone]]
		+	[[Category: Inhibitor]]
		+	[[Category: Malaria]]
		+	[[Category: Protein translation]]
		+	[[Category: Pr]]
		+	[[Category: Synthetase]]

OCA: Protected "4twa" [edit=sysop:move=sysop]

2014-07-09T06:59:56Z

Protected "4twa" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:59, 9 July 2014

OCA: New page: '''Unreleased structure''' The entry 4twa is ON HOLD Authors: Jain, V., Yogavel, M., Sharma, A. Description: Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparu...

2014-07-09T06:59:55Z

New page: '''Unreleased structure''' The entry 4twa is ON HOLD Authors: Jain, V., Yogavel, M., Sharma, A. Description: Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparu...

New page

'''Unreleased structure'''

The entry 4twa is ON HOLD

Authors: Jain, V., Yogavel, M., Sharma, A.

Description: Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum