4txd - Revision history

OCA at 11:18, 9 May 2024

2024-05-09T11:18:40Z

←Older revision		Revision as of 11:18, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermofilum_pendens Thermofilum pendens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermofilum_pendens Thermofilum pendens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.818Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [https://pdbe.org/4txd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [https://www.ebi.ac.uk/pdbsum/4txd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [https://pdbe.org/4txd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [https://www.ebi.ac.uk/pdbsum/4txd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:50, 22 March 2023

2023-03-22T07:50:49Z

←Older revision		Revision as of 07:50, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4txd' size='340' side='right'caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4txd' size='340' side='right'caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dsm_2475 Dsm 2475~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4TXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermofilum_pendens Thermofilum pendens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [https://pdbe.org/4txd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [https://www.ebi.ac.uk/pdbsum/4txd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tpen_1325 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2269 DSM 2475])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [~~http~~://pdbe.org/4txd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4txd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A1RZU2_THEPD A1RZU2_THEPD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dsm 2475]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Conti, E~~]]	+	[[Category: Thermofilum pendens]]
-	[[Category: ~~Hrle, A~~]]	+	[[Category: Conti E]]
-	[[Category: ~~Cas7]]~~	+	[[Category: Hrle A]]
-	~~[[Category: Crispr]]~~	+
-	~~[[Category: Prokaryotic immune system]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rrm domain]]~~	+
-	~~[[Category: Type i-d~~]]	+

OCA at 14:22, 10 May 2019

2019-05-10T14:22:21Z

←Older revision		Revision as of 14:22, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of Thermofilum pendens Csc2==		==Crystal structure of Thermofilum pendens Csc2==
-	<StructureSection load='4txd' size='340' side='right' caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='4txd' size='340' side='right'caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_2475 Dsm 2475]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tpen_1325 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2269 DSM 2475])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://pdbe.org/4txd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://pdbe.org/4txd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 2475]]
		+	[[Category: Large Structures]]
	[[Category: Conti, E]]		[[Category: Conti, E]]
	[[Category: Hrle, A]]		[[Category: Hrle, A]]

OCA at 01:19, 19 January 2017

2017-01-19T01:19:02Z

←Older revision		Revision as of 01:19, 19 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of Thermofilum pendens Csc2==		==Crystal structure of Thermofilum pendens Csc2==
	<StructureSection load='4txd' size='340' side='right' caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4txd' size='340' side='right' caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://pdbe.org/4txd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4txd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4txd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:00, 26 March 2015

2015-03-26T08:00:08Z

←Older revision		Revision as of 08:00, 26 March 2015
Line 11:		Line 11:
	Upon pathogen invasion, bacteria and archaea activate an RNA-interference-like mechanism termed CRISPR (clustered regularly interspaced short palindromic repeats). A large family of Cas (CRISPR-associated) proteins mediates the different stages of this sophisticated immune response. Bioinformatic studies have classified the Cas proteins into families, according to their sequences and respective functions. These range from the insertion of the foreign genetic elements into the host genome to the activation of the interference machinery as well as target degradation upon attack. Cas7 family proteins are central to the type I and type III interference machineries as they constitute the backbone of the large interference complexes. Here we report the crystal structure of Thermofilum pendens Csc2, a Cas7 family protein of type I-D. We found that Csc2 forms a core RRM-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. Comparison with other Cas7 family proteins reveals a set of similar structural features both in the core and in the peripheral domains, despite the absence of significant sequence similarity. T. pendens Csc2 binds single-stranded RNA in vitro in a sequence-independent manner. Using a crosslinking - mass-spectrometry approach, we mapped the RNA-binding surface to a positively charged surface patch on T. pendens Csc2. Thus our analysis of the key structural and functional features of T. pendens Csc2 highlights recurring themes and evolutionary relationships in type I and type III Cas proteins.		Upon pathogen invasion, bacteria and archaea activate an RNA-interference-like mechanism termed CRISPR (clustered regularly interspaced short palindromic repeats). A large family of Cas (CRISPR-associated) proteins mediates the different stages of this sophisticated immune response. Bioinformatic studies have classified the Cas proteins into families, according to their sequences and respective functions. These range from the insertion of the foreign genetic elements into the host genome to the activation of the interference machinery as well as target degradation upon attack. Cas7 family proteins are central to the type I and type III interference machineries as they constitute the backbone of the large interference complexes. Here we report the crystal structure of Thermofilum pendens Csc2, a Cas7 family protein of type I-D. We found that Csc2 forms a core RRM-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. Comparison with other Cas7 family proteins reveals a set of similar structural features both in the core and in the peripheral domains, despite the absence of significant sequence similarity. T. pendens Csc2 binds single-stranded RNA in vitro in a sequence-independent manner. Using a crosslinking - mass-spectrometry approach, we mapped the RNA-binding surface to a positively charged surface patch on T. pendens Csc2. Thus our analysis of the key structural and functional features of T. pendens Csc2 highlights recurring themes and evolutionary relationships in type I and type III Cas proteins.

-	Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.,Hrle A, Maier LK, Sharma K, Ebert J, Basquin C, Urlaub H, Marchfelder A, Conti E RNA Biol. 2014 Aug 12;11(8). PMID:~~25117179~~<ref>PMID:~~25117179~~</ref>	+	Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.,Hrle A, Maier LK, Sharma K, Ebert J, Basquin C, Urlaub H, Marchfelder A, Conti E RNA Biol. 2014 Aug 3;11(8):1072-82. doi: 10.4161/rna.29893. PMID:25483036<ref>PMID:25483036</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

OCA at 14:29, 5 January 2015

2015-01-05T14:29:11Z

←Older revision		Revision as of 14:29, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Conti, E.]]	+	[[Category: Conti, E]]
-	[[Category: Hrle, A.]]	+	[[Category: Hrle, A]]
	[[Category: Cas7]]		[[Category: Cas7]]
	[[Category: Crispr]]		[[Category: Crispr]]

OCA at 08:36, 27 August 2014

2014-08-27T08:36:41Z

←Older revision		Revision as of 08:36, 27 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Thermofilum pendens Csc2==
		+	<StructureSection load='4txd' size='340' side='right' caption='[[4txd]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4txd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n0l\|4n0l]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txd RCSB], [http://www.ebi.ac.uk/pdbsum/4txd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Upon pathogen invasion, bacteria and archaea activate an RNA-interference-like mechanism termed CRISPR (clustered regularly interspaced short palindromic repeats). A large family of Cas (CRISPR-associated) proteins mediates the different stages of this sophisticated immune response. Bioinformatic studies have classified the Cas proteins into families, according to their sequences and respective functions. These range from the insertion of the foreign genetic elements into the host genome to the activation of the interference machinery as well as target degradation upon attack. Cas7 family proteins are central to the type I and type III interference machineries as they constitute the backbone of the large interference complexes. Here we report the crystal structure of Thermofilum pendens Csc2, a Cas7 family protein of type I-D. We found that Csc2 forms a core RRM-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. Comparison with other Cas7 family proteins reveals a set of similar structural features both in the core and in the peripheral domains, despite the absence of significant sequence similarity. T. pendens Csc2 binds single-stranded RNA in vitro in a sequence-independent manner. Using a crosslinking - mass-spectrometry approach, we mapped the RNA-binding surface to a positively charged surface patch on T. pendens Csc2. Thus our analysis of the key structural and functional features of T. pendens Csc2 highlights recurring themes and evolutionary relationships in type I and type III Cas proteins.

-	~~The entry 4txd is ON HOLD~~	+	Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.,Hrle A, Maier LK, Sharma K, Ebert J, Basquin C, Urlaub H, Marchfelder A, Conti E RNA Biol. 2014 Aug 12;11(8). PMID:25117179<ref>PMID:25117179</ref>

-	~~Authors: Hrle~~, A., Conti, E.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Conti, E.]]
		+	[[Category: Hrle, A.]]
		+	[[Category: Cas7]]
		+	[[Category: Crispr]]
		+	[[Category: Prokaryotic immune system]]
		+	[[Category: Rna binding]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rrm domain]]
		+	[[Category: Type i-d]]

OCA: Protected "4txd" [edit=sysop:move=sysop]

2014-07-16T09:56:33Z

Protected "4txd" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:56, 16 July 2014

OCA: New page: '''Unreleased structure''' The entry 4txd is ON HOLD Authors: Hrle, A., Conti, E. Description:

2014-07-16T09:56:32Z

New page: '''Unreleased structure''' The entry 4txd is ON HOLD Authors: Hrle, A., Conti, E. Description:

New page

'''Unreleased structure'''

The entry 4txd is ON HOLD

Authors: Hrle, A., Conti, E.

Description: