4u09 - Revision history

OCA at 07:54, 22 March 2023

2023-03-22T07:54:05Z

←Older revision		Revision as of 07:54, 22 March 2023
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	<StructureSection load='4u09' size='340' side='right'caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4u09' size='340' side='right'caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u09]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lepic Lepic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U09 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U09 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u09]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans_serovar_Copenhageni_str._Fiocruz_L1-130 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U09 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [https://pdbe.org/4u09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [https://www.ebi.ac.uk/pdbsum/4u09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u09 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIC_12759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267671 LEPIC])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [~~http~~://pdbe.org/4u09 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u09 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u09 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q72NS0_LEPIC Q72NS0_LEPIC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lepic~~]]	+	[[Category: Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]]
-	[[Category: Haouz, A]]	+	[[Category: Haouz A]]
-	[[Category: Picardeau, M]]	+	[[Category: Picardeau M]]
-	[[Category: Saul~~, F A~~]]	+	[[Category: Saul FA]]
-	[[Category: Shepard, W]]	+	[[Category: Shepard W]]
-	~~[[Category: Lrr protein]]~~	+
-	~~[[Category: Pathogen]]~~	+
-	~~[[Category: Unknown function]]~~	+
-	~~[[Category: Virulence factor~~]]	+

OCA at 15:12, 10 May 2019

2019-05-10T15:12:21Z

←Older revision		Revision as of 15:12, 10 May 2019
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	==Structure of Leptospira interrogans LRR protein LIC12759==		==Structure of Leptospira interrogans LRR protein LIC12759==
-	<StructureSection load='4u09' size='340' side='right' caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4u09' size='340' side='right'caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u09]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U09 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lepic Lepic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U09 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIC_12759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267671 LEPIC])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://pdbe.org/4u09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u09 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://pdbe.org/4u09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u09 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lepic]]
	[[Category: Haouz, A]]		[[Category: Haouz, A]]
	[[Category: Picardeau, M]]		[[Category: Picardeau, M]]

OCA at 17:08, 22 March 2017

2017-03-22T17:08:35Z

←Older revision		Revision as of 17:08, 22 March 2017
Line 1:		Line 1:
		+
	==Structure of Leptospira interrogans LRR protein LIC12759==		==Structure of Leptospira interrogans LRR protein LIC12759==
	<StructureSection load='4u09' size='340' side='right' caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4u09' size='340' side='right' caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://pdbe.org/4u09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u09 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u09" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:02, 17 June 2015

2015-06-17T09:02:46Z

←Older revision		Revision as of 09:02, 17 June 2015
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pathogenic Leptospira spp. are the agents of leptospirosis, an emerging zoonotic disease. Analyses of Leptospira genomes have shown that the pathogenic leptospires (but not the saprophytes) possess a large number of genes encoding proteins containing leucine-rich repeat (LRR) domains. In other pathogenic bacteria, proteins with LRR domains have been shown to be involved in mediating host-cell attachment and invasion, but their functions remain unknown in Leptospira. To gain insight into the potential function of leptospiral LRR proteins, the crystal structures of four LRR proteins that represent a novel subfamily with consecutive stretches of a 23-amino-acid LRR repeat motif have been solved. The four proteins analyzed adopt the characteristic alpha/beta-solenoid horseshoe fold. The exposed residues of the inner concave surfaces of the solenoid, which constitute a putative functional binding site, are not conserved. The various leptospiral LRR proteins could therefore recognize distinct structural motifs of different host proteins and thus serve separate and complementary functions in the physiology of these bacteria.
		+
		+	Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans.,Miras I, Saul F, Nowakowski M, Weber P, Haouz A, Shepard W, Picardeau M Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1351-9. doi:, 10.1107/S139900471500704X. Epub 2015 May 23. PMID:26057675<ref>PMID:26057675</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:44, 3 June 2015

2015-06-03T12:44:15Z

←Older revision		Revision as of 12:44, 3 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of Leptospira interrogans LRR protein LIC12759==
-		+	<StructureSection load='4u09' size='340' side='right' caption='[[4u09]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~The entry~~ 4u09 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4u09]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U09 FirstGlance]. <br>
-	~~Authors~~: ~~Shepard, W~~.~~, Saul, F~~.A., ~~Haouz~~, A., ~~Picardeau~~, M.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~Description~~:	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4tzh\|4tzh]], [[4u06\|4u06]], [[4u08\|4u08]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u09 RCSB], [http://www.ebi.ac.uk/pdbsum/4u09 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Haouz, A]]		[[Category: Haouz, A]]
-	[[Category: Shepard, W]]
	[[Category: Picardeau, M]]		[[Category: Picardeau, M]]
-	[[Category: Saul, F.A]]	+	[[Category: Saul, F A]]
		+	[[Category: Shepard, W]]
		+	[[Category: Lrr protein]]
		+	[[Category: Pathogen]]
		+	[[Category: Unknown function]]
		+	[[Category: Virulence factor]]

OCA at 18:02, 24 December 2014

2014-12-24T18:02:04Z

←Older revision		Revision as of 18:02, 24 December 2014
Line 5:		Line 5:
	Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M.		Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: Haouz, A]]
		+	[[Category: Shepard, W]]
		+	[[Category: Picardeau, M]]
		+	[[Category: Saul, F.A]]

OCA at 01:25, 7 August 2014

2014-08-07T01:25:16Z

←Older revision		Revision as of 01:25, 7 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u09 is ON HOLD	+	The entry 4u09 is ON HOLD until Paper Publication

	Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M.		Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M.

	Description:		Description:

OCA: Protected "4u09" [edit=sysop:move=sysop]

2014-07-23T07:23:45Z

Protected "4u09" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:23, 23 July 2014

OCA: New page: '''Unreleased structure''' The entry 4u09 is ON HOLD Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M. Description:

2014-07-23T07:23:44Z

New page: '''Unreleased structure''' The entry 4u09 is ON HOLD Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M. Description:

New page

'''Unreleased structure'''

The entry 4u09 is ON HOLD

Authors: Shepard, W., Saul, F.A., Haouz, A., Picardeau, M.

Description: