4u14 - Revision history

OCA at 00:49, 28 December 2023

2023-12-28T00:49:10Z

←Older revision		Revision as of 00:49, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U14 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U14 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.57Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [https://pdbe.org/4u14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [https://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [https://pdbe.org/4u14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [https://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:56, 22 March 2023

2023-03-22T07:56:20Z

←Older revision		Revision as of 07:56, 22 March 2023
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	<StructureSection load='4u14' size='340' side='right'caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>		<StructureSection load='4u14' size='340' side='right'caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U14 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [https://pdbe.org/4u14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [https://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Chrm3, Chrm-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [~~http~~://pdbe.org/4u14 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4u14" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4u14" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Muscarinic acetylcholine receptor\|Muscarinic acetylcholine receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Escherichia virus T4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lysozyme~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Kobilka~~, B K~~]]	+	[[Category: Kobilka BK]]
-	[[Category: Matt~~, R A~~]]	+	[[Category: Matt RA]]
-	[[Category: Thorsen~~, T S~~]]	+	[[Category: Thorsen TS]]
-	[[Category: Weis~~, W I]]~~	+	[[Category: Weis WI]]
-	~~[[Category: Alpha helix]]~~	+
-	~~[[Category: Chimera protein]]~~	+
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: T4 lysozyme~~]]	+

OCA at 07:18, 27 November 2019

2019-11-27T07:18:10Z

←Older revision		Revision as of 07:18, 27 November 2019
Line 3:		Line 3:
	<StructureSection load='4u14' size='340' side='right'caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>		<StructureSection load='4u14' size='340' side='right'caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U14 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Chrm3, Chrm-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://pdbe.org/4u14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://pdbe.org/4u14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 06:52, 10 July 2019

2019-07-10T06:52:17Z

←Older revision		Revision as of 06:52, 10 July 2019
Line 1:		Line 1:

	==Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)==		==Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)==
-	<StructureSection load='4u14' size='340' side='right' caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>	+	<StructureSection load='4u14' size='340' side='right'caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U14 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U14 FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Kobilka, B K]]		[[Category: Kobilka, B K]]

OCA at 16:58, 5 August 2016

2016-08-05T16:58:04Z

←Older revision		Revision as of 16:58, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)==		==Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)==
	<StructureSection load='4u14' size='340' side='right' caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>		<StructureSection load='4u14' size='340' side='right' caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://pdbe.org/4u14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u14 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u14" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 24 December 2014

2014-12-24T10:50:59Z

←Older revision		Revision as of 10:50, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACM3_RAT ACM3_RAT]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<ref>PMID:1527051</ref> <ref>PMID:1657592</ref> <ref>PMID:22358844</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters. Most GPCR crystal structures have been obtained using a fusion protein strategy where the flexible third intracellular loop is replaced by T4 lysozyme (T4L). However, wild-type T4L may not be ideally suited for all GPCRs because of its size and the inherent flexibility between the N- and C-terminal subdomains. Here we report two modified T4L variants, designed to address flexibility and size, that can be used to optimize crystal quality or promote alternative packing interactions. These variants were tested on the M3 muscarinic receptor (M3). The original M3-T4L fusion protein produced twinned crystals that yielded a 3.4 A structure from a 70 crystal data set. We replaced T4L with the modified T4L variants. Both T4L variants yielded M3 muscarinic receptor crystals with alternate lattices that were not twinned, including one that was solved at 2.8 A resolution.
		+
		+	Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.,Thorsen TS, Matt R, Weis WI, Kobilka BK Structure. 2014 Oct 23;22(11):1657-1664. doi: 10.1016/j.str.2014.08.022. PMID:25450769<ref>PMID:25450769</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:16, 26 November 2014

2014-11-26T08:16:41Z

←Older revision		Revision as of 08:16, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)==
-		+	<StructureSection load='4u14' size='340' side='right' caption='[[4u14]], [[Resolution\|resolution]] 3.57Å' scene=''>
-	~~The entry~~ 4u14 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4u14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U14 FirstGlance]. <br>
-	~~Authors~~: ~~Thorsen~~, T.S., ~~Matt~~, R.A., ~~Weis~~, W.I., Kobilka, B.K.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4u15\|4u15]], [[4u16\|4u16]]</td></tr>
-	~~Description~~: ~~Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized~~ T4 lysozyme ~~(dsT4L)~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u14 RCSB], [http://www.ebi.ac.uk/pdbsum/4u14 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lysozyme]]
		+	[[Category: Kobilka, B K]]
		+	[[Category: Matt, R A]]
		+	[[Category: Thorsen, T S]]
		+	[[Category: Weis, W I]]
		+	[[Category: Alpha helix]]
		+	[[Category: Chimera protein]]
		+	[[Category: Fusion protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: T4 lysozyme]]

OCA at 10:15, 29 October 2014

2014-10-29T10:15:29Z

←Older revision		Revision as of 10:15, 29 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u14 is ON HOLD	+	The entry 4u14 is ON HOLD until Paper Publication

	Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.		Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.

	Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)		Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)

OCA at 09:37, 20 October 2014

2014-10-20T09:37:41Z

←Older revision		Revision as of 09:37, 20 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u14 is ON HOLD ~~until Paper Publication~~	+	The entry 4u14 is ON HOLD

	Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.		Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.

	Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)		Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)

OCA at 08:44, 24 September 2014

2014-09-24T08:44:27Z

←Older revision		Revision as of 08:44, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u14 is ON HOLD	+	The entry 4u14 is ON HOLD until Paper Publication

	Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.		Authors: Thorsen, T.S., Matt, R.A., Weis, W.I., Kobilka, B.K.

	Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)		Description: Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)