4u9c - Revision history

OCA at 00:50, 28 December 2023

2023-12-28T00:50:33Z

←Older revision		Revision as of 00:50, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_CU385 Neisseria meningitidis CU385]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U9C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_CU385 Neisseria meningitidis CU385]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U9C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [https://pdbe.org/4u9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [https://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.995Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [https://pdbe.org/4u9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [https://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:10, 22 March 2023

2023-03-22T08:10:23Z

←Older revision		Revision as of 08:10, 22 March 2023
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	<StructureSection load='4u9c' size='340' side='right'caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4u9c' size='340' side='right'caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Neisseria_meningitidis_cu385~~ Neisseria meningitidis ~~cu385~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4U9C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_CU385 Neisseria meningitidis CU385]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U9C FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMBCU385_0651 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=935597 Neisseria meningitidis CU385])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [https://pdbe.org/4u9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [https://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [~~http~~://pdbe.org/4u9c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Neisseria meningitidis ~~cu385~~]]	+	[[Category: Neisseria meningitidis CU385]]
-	[[Category: Arutyunova, E]]	+	[[Category: Arutyunova E]]
-	[[Category: Brooks~~, C L~~]]	+	[[Category: Brooks CL]]
-	[[Category: Lemieux~~, M J]]~~	+	[[Category: Lemieux MJ]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Lactoferrin]]~~	+
-	~~[[Category: Lactoferrin-binding protein]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Transferrin~~]]	+

OCA at 09:02, 21 May 2019

2019-05-21T09:02:56Z

←Older revision		Revision as of 09:02, 21 May 2019
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	==STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS==		==STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS==
-	<StructureSection load='4u9c' size='340' side='right' caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4u9c' size='340' side='right'caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_cu385 Neisseria meningitidis cu385]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [http://pdbe.org/4u9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [http://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NMBCU385_0651 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=935597 Neisseria meningitidis CU385])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [http://pdbe.org/4u9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [http://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4u9c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4u9c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transferrin-binding protein\|Transferrin-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Neisseria meningitidis cu385]]
	[[Category: Arutyunova, E]]		[[Category: Arutyunova, E]]
	[[Category: Brooks, C L]]		[[Category: Brooks, C L]]

OCA at 17:12, 11 August 2016

2016-08-11T17:12:49Z

←Older revision		Revision as of 17:12, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS==		==STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS==
	<StructureSection load='4u9c' size='340' side='right' caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4u9c' size='340' side='right' caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [http://www.ebi.ac.uk/pdbsum/4u9c PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [http://pdbe.org/4u9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [http://www.ebi.ac.uk/pdbsum/4u9c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4u9c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:50, 25 January 2015

2015-01-25T07:50:40Z

←Older revision		Revision as of 07:50, 25 January 2015
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arutyunova, E.]]	+	[[Category: Arutyunova, E]]
-	[[Category: Brooks, C L.]]	+	[[Category: Brooks, C L]]
-	[[Category: Lemieux, M J.]]	+	[[Category: Lemieux, M J]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Lactoferrin]]		[[Category: Lactoferrin]]

OCA at 11:50, 22 October 2014

2014-10-22T11:50:06Z

←Older revision		Revision as of 11:50, 22 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS==
		+	<StructureSection load='4u9c' size='340' side='right' caption='[[4u9c]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4u9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9C FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u9c RCSB], [http://www.ebi.ac.uk/pdbsum/4u9c PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pathogens have evolved a range of mechanisms to acquire iron from the host during infection. Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host glycoproteins lactoferrin and transferrin. The homologous iron-transport systems consist of a membrane-bound transporter and an accessory lipoprotein. While the mechanism behind iron acquisition from transferrin is well understood, relatively little is known regarding how iron is extracted from lactoferrin. Here, the crystal structure of the N-terminal domain (N-lobe) of the accessory lipoprotein lactoferrin-binding protein B (LbpB) from the pathogen Neisseria meningitidis is reported. The structure is highly homologous to the previously determined structures of the accessory lipoprotein transferrin-binding protein B (TbpB) and LbpB from the bovine pathogen Moraxella bovis. Docking the LbpB structure with lactoferrin reveals extensive binding interactions with the N1 subdomain of lactoferrin. The nature of the interaction precludes apolactoferrin from binding LbpB, ensuring the specificity of iron-loaded lactoferrin. The specificity of LbpB safeguards proper delivery of iron-bound lactoferrin to the transporter lactoferrin-binding protein A (LbpA). The structure also reveals a possible secondary role for LbpB in protecting the bacteria from host defences. Following proteolytic digestion of lactoferrin, a cationic peptide derived from the N-terminus is released. This peptide, called lactoferricin, exhibits potent antimicrobial effects. The docked model of LbpB with lactoferrin reveals that LbpB interacts extensively with the N-terminal lactoferricin region. This may provide a venue for preventing the production of the peptide by proteolysis, or directly sequestering the peptide, protecting the bacteria from the toxic effects of lactoferricin.

-	The ~~entry 4u9c is ON HOLD until Paper Publication~~	+	The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences.,Brooks CL, Arutyunova E, Lemieux MJ Acta Crystallogr F Struct Biol Commun. 2014 Oct 1;70(Pt 10):1312-7. doi:, 10.1107/S2053230X14019372. Epub 2014 Sep 25. PMID:25286931<ref>PMID:25286931</ref>

-	~~Authors: Brooks~~, C.L., Arutyunova, E., Lemieux, M.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~STRUCTURE OF THE LBPB N~~-~~LOBE FROM NEISSERIA MENINGITIDIS~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arutyunova, E.]]
		+	[[Category: Brooks, C L.]]
		+	[[Category: Lemieux, M J.]]
		+	[[Category: Beta barrel]]
		+	[[Category: Lactoferrin]]
		+	[[Category: Lactoferrin-binding protein]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Transferrin]]

OCA at 08:49, 24 September 2014

2014-09-24T08:49:36Z

←Older revision		Revision as of 08:49, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4u9c is ON HOLD	+	The entry 4u9c is ON HOLD until Paper Publication

	Authors: Brooks, C.L., Arutyunova, E., Lemieux, M.J.		Authors: Brooks, C.L., Arutyunova, E., Lemieux, M.J.

	Description: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS		Description: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS

OCA: Protected "4u9c" [edit=sysop:move=sysop]

2014-08-13T08:09:22Z

Protected "4u9c" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:09, 13 August 2014

OCA: New page: '''Unreleased structure''' The entry 4u9c is ON HOLD Authors: Brooks, C.L., Arutyunova, E., Lemieux, M.J. Description: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS

2014-08-13T08:09:20Z

New page: '''Unreleased structure''' The entry 4u9c is ON HOLD Authors: Brooks, C.L., Arutyunova, E., Lemieux, M.J. Description: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS

New page

'''Unreleased structure'''

The entry 4u9c is ON HOLD

Authors: Brooks, C.L., Arutyunova, E., Lemieux, M.J.

Description: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS