4uet - Revision history

OCA at 08:20, 22 March 2023

2023-03-22T08:20:54Z

←Older revision		Revision as of 08:20, 22 March 2023
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	==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==		==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==
-	<StructureSection load='4uet' size='340' side='right'caption='[[4uet~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='4uet' size='340' side='right'caption='[[4uet]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human_hookworm Human hookworm~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Necator_americanus Necator americanus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UET FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uet OCA], [~~http~~://pdbe.org/4uet PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uet RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uet PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uet ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uet OCA], [https://pdbe.org/4uet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uet RCSB], [https://www.ebi.ac.uk/pdbsum/4uet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uet ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/W2SRJ3_NECAM W2SRJ3_NECAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Retinol-binding protein\|Retinol-binding protein]]	+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human hookworm]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cooper, A~~]]	+	[[Category: Necator americanus]]
-	[[Category: ~~Corsico, B~~]]	+	[[Category: Cooper A]]
-	[[Category: ~~Griffiths, K~~]]	+	[[Category: Corsico B]]
-	[[Category: ~~Kennedy, M W]]~~	+	[[Category: Griffiths K]]
-	~~[[Category: Rey-Burusco, M F~~]]	+	[[Category: Ibanez Shimabukuro M]]
-	[[Category: Shimabukuro, M ~~Ibanez~~]]	+	[[Category: Kennedy MW]]
-	[[Category: ~~Smith, B O~~]]	+	[[Category: Rey-Burusco MF]]
-	[[Category: ~~All~~-~~alpha~~]]	+	[[Category: Smith BO]]
-	[[Category: ~~Fatty acid binding]]~~	+
-	~~[[Category: Retinol binding]]~~	+
-	~~[[Category: Retinol-binding protein~~]]	+

OCA at 07:24, 23 October 2019

2019-10-23T07:24:30Z

←Older revision		Revision as of 07:24, 23 October 2019
Line 1:		Line 1:

	==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==		==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==
-	<StructureSection load='4uet' size='340' side='right' caption='[[4uet]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='4uet' size='340' side='right'caption='[[4uet]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_hookworm Human hookworm]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UET FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_hookworm Human hookworm]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UET FirstGlance]. <br>
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 4uet" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4uet" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Retinol-binding protein\|Retinol-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human hookworm]]		[[Category: Human hookworm]]
		+	[[Category: Large Structures]]
	[[Category: Cooper, A]]		[[Category: Cooper, A]]
	[[Category: Corsico, B]]		[[Category: Corsico, B]]

OCA at 16:57, 16 November 2017

2017-11-16T16:57:23Z

←Older revision		Revision as of 16:57, 16 November 2017
Line 1:		Line 1:
		+
	==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==		==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==
	<StructureSection load='4uet' size='340' side='right' caption='[[4uet]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='4uet' size='340' side='right' caption='[[4uet]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_hookworm Human hookworm]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UET FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uet OCA], [http://pdbe.org/4uet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uet RCSB], [http://www.ebi.ac.uk/pdbsum/4uet PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uet OCA], [http://pdbe.org/4uet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uet RCSB], [http://www.ebi.ac.uk/pdbsum/4uet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uet ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human hookworm]]
	[[Category: Cooper, A]]		[[Category: Cooper, A]]
	[[Category: Corsico, B]]		[[Category: Corsico, B]]

OCA at 19:48, 30 November 2015

2015-11-30T19:48:18Z

←Older revision		Revision as of 19:48, 30 November 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus==
		+	<StructureSection load='4uet' size='340' side='right' caption='[[4uet]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uet]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UET FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uet OCA], [http://pdbe.org/4uet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uet RCSB], [http://www.ebi.ac.uk/pdbsum/4uet PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fatty acid and retinol-binding proteins (FARs) comprise a family of unusual alpha-helix rich lipid-binding proteins found exclusively in nematodes. They are secreted into host tissues by parasites of plants, animals and humans. The structure of a FAR protein from the free-living nematode Caenorhabditis elegans is available, but this protein [C. elegans FAR-7 (Ce-FAR-7)] is from a subfamily of FARs that does not appear to be important at the host/parasite interface. We have therefore examined [Necator americanus FAR-1 (Na-FAR-1)] from the blood-feeding intestinal parasite of humans, N. americanus. The 3D structure of Na-FAR-1 in its ligand-free and ligand-bound forms, determined by NMR (nuclear magnetic resonance) spectroscopy and X-ray crystallography respectively, reveals an alpha-helical fold similar to Ce-FAR-7, but Na-FAR-1 possesses a larger and more complex internal ligand-binding cavity and an additional C-terminal alpha-helix. Titration of apo-Na-FAR-1 with oleic acid, analysed by NMR chemical shift perturbation, reveals that at least four distinct protein-ligand complexes can be formed. Na-FAR-1 and possibly other FARs may have a wider repertoire for hydrophobic ligand binding, as confirmed in the present study by our finding that a range of neutral and polar lipids co-purify with the bacterially expressed recombinant protein. Finally, we show by immunohistochemistry that Na-FAR-1 is present in adult worms with a tissue distribution indicative of possible roles in nutrient acquisition by the parasite and in reproduction in the male.

-	~~The entry 4uet is ON HOLD until Paper Publication~~	+	Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus.,Rey-Burusco MF, Ibanez-Shimabukuro M, Gabrielsen M, Franchini GR, Roe AJ, Griffiths K, Zhan B, Cooper A, Kennedy MW, Corsico B, Smith BO Biochem J. 2015 Nov 1;471(3):403-14. doi: 10.1042/BJ20150068. Epub 2015 Aug 28. PMID:26318523<ref>PMID:26318523</ref>

-	~~Authors: REY-BURUSCO~~, M.F.~~, IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B., SMITH, B.O., GRIFFITHS, K~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na~~-~~FAR~~-~~1 from Necator americanus~~	+	<div class="pdbe-citations 4uet" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cooper, A]]
	[[Category: Corsico, B]]		[[Category: Corsico, B]]
-	[[Category: Smith, B.O]]
-	[[Category: Cooper, A]]
-	[[Category: Rey-Burusco, M.F]]
-	[[Category: Ibanez Shimabukuro, M]]
-	[[Category: Kennedy, M.W]]
	[[Category: Griffiths, K]]		[[Category: Griffiths, K]]
		+	[[Category: Kennedy, M W]]
		+	[[Category: Rey-Burusco, M F]]
		+	[[Category: Shimabukuro, M Ibanez]]
		+	[[Category: Smith, B O]]
		+	[[Category: All-alpha]]
		+	[[Category: Fatty acid binding]]
		+	[[Category: Retinol binding]]
		+	[[Category: Retinol-binding protein]]

OCA at 11:24, 14 January 2015

2015-01-14T11:24:55Z

←Older revision		Revision as of 11:24, 14 January 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uet is ON HOLD until ~~sometime in the future~~	+	The entry 4uet is ON HOLD until Paper Publication

-	Authors: REY BURUSCO, M., IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B., SMITH, B.O., GRIFFITHS, K.	+	Authors: REY-BURUSCO, M.F., IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B., SMITH, B.O., GRIFFITHS, K.

	Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus		Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Corsico, B]]		[[Category: Corsico, B]]
-	[[Category: Rey Burusco, M]]
	[[Category: Smith, B.O]]		[[Category: Smith, B.O]]
	[[Category: Cooper, A]]		[[Category: Cooper, A]]
		+	[[Category: Rey-Burusco, M.F]]
	[[Category: Ibanez Shimabukuro, M]]		[[Category: Ibanez Shimabukuro, M]]
	[[Category: Kennedy, M.W]]		[[Category: Kennedy, M.W]]
	[[Category: Griffiths, K]]		[[Category: Griffiths, K]]

OCA at 18:30, 24 December 2014

2014-12-24T18:30:33Z

←Older revision		Revision as of 18:30, 24 December 2014
Line 6:		Line 6:

	Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus		Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus
		+	[[Category: Unreleased Structures]]
		+	[[Category: Corsico, B]]
		+	[[Category: Rey Burusco, M]]
		+	[[Category: Smith, B.O]]
		+	[[Category: Cooper, A]]
		+	[[Category: Ibanez Shimabukuro, M]]
		+	[[Category: Kennedy, M.W]]
		+	[[Category: Griffiths, K]]

OCA: Protected "4uet" [edit=sysop:move=sysop]

2014-12-24T09:41:41Z

Protected "4uet" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:41, 24 December 2014

OCA: New page: '''Unreleased structure''' The entry 4uet is ON HOLD until sometime in the future Authors: REY BURUSCO, M., IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B....

2014-12-24T09:41:40Z

New page: '''Unreleased structure''' The entry 4uet is ON HOLD until sometime in the future Authors: REY BURUSCO, M., IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B....

New page

'''Unreleased structure'''

The entry 4uet is ON HOLD until sometime in the future

Authors: REY BURUSCO, M., IBANEZ SHIMABUKURO, M., GRIFFITHS, K., COOPER, A., KENNEDY, M.W., CORSICO, B., SMITH, B.O., GRIFFITHS, K.

Description: Diversity in the structures and ligand binding sites among the fatty acid and retinol binding proteins of nematodes revealed by Na-FAR-1 from Necator americanus