4uin - Revision history

OCA at 10:29, 10 January 2024

2024-01-10T10:29:55Z

←Older revision		Revision as of 10:29, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [https://pdbe.org/4uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [https://www.ebi.ac.uk/pdbsum/4uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uin ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [https://pdbe.org/4uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [https://www.ebi.ac.uk/pdbsum/4uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uin ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:26, 22 March 2023

2023-03-22T08:26:35Z

←Older revision		Revision as of 08:26, 22 March 2023
Line 3:		Line 3:
	<StructureSection load='4uin' size='340' side='right'caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4uin' size='340' side='right'caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [https://pdbe.org/4uin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [https://www.ebi.ac.uk/pdbsum/4uin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uin ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [~~http~~://pdbe.org/4uin PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uin PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uin ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 22:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aster~~, R H~~]]	+	[[Category: Aster RH]]
-	[[Category: Bougie~~, D W~~]]	+	[[Category: Bougie DW]]
-	[[Category: Springer~~, T A~~]]	+	[[Category: Springer TA]]
-	[[Category: Zhu, J]]	+	[[Category: Zhu J]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mouse mab]]~~	+
-	~~[[Category: Quinine-dependent~~]]	+

OCA at 10:51, 26 February 2020

2020-02-26T10:51:43Z

←Older revision		Revision as of 10:51, 26 February 2020
Line 1:		Line 1:

	==crystal structure of quinine-dependent Fab 314.3 with quinine==		==crystal structure of quinine-dependent Fab 314.3 with quinine==
-	<StructureSection load='4uin' size='340' side='right' caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4uin' size='340' side='right'caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIN FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aster, R H]]		[[Category: Aster, R H]]

OCA at 06:17, 19 April 2017

2017-04-19T06:17:57Z

←Older revision		Revision as of 06:17, 19 April 2017
Line 1:		Line 1:
		+
	==crystal structure of quinine-dependent Fab 314.3 with quinine==		==crystal structure of quinine-dependent Fab 314.3 with quinine==
	<StructureSection load='4uin' size='340' side='right' caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4uin' size='340' side='right' caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [http://pdbe.org/4uin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [http://www.ebi.ac.uk/pdbsum/4uin PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [http://pdbe.org/4uin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [http://www.ebi.ac.uk/pdbsum/4uin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uin ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:23, 30 November 2015

2015-11-30T19:23:01Z

←Older revision		Revision as of 19:23, 30 November 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [http://www.ebi.ac.uk/pdbsum/4uin PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [http://pdbe.org/4uin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [http://www.ebi.ac.uk/pdbsum/4uin PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uin" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:28, 2 September 2015

2015-09-02T12:28:15Z

←Older revision		Revision as of 12:28, 2 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==crystal structure of quinine-dependent Fab 314.3 with quinine==
		+	<StructureSection load='4uin' size='340' side='right' caption='[[4uin]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QI9:QUININE'>QI9</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uik\|4uik]], [[4uil\|4uil]], [[4uim\|4uim]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uin RCSB], [http://www.ebi.ac.uk/pdbsum/4uin PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Drug-induced immune thrombocytopenia (DITP) is caused by antibodies that react with specific platelet membrane glycoproteins when the provoking drug is present. More than 100 drugs have been implicated as triggers for this condition, quinine being one of the most common. The cause of DITP in most cases appears to be a drug-induced antibody that binds to a platelet membrane glycoprotein only when drug is present. How soluble drug promotes binding of an otherwise non-reactive immunoglobulin to its target, leading to platelet destruction is uncertain, in part because of the difficulties of working with polyclonal human antibodies usually available only in small quantities. Recently, quinine-dependent murine monoclonal antibodies were developed that recognize a defined epitope on the beta-propeller domain of the platelet integrin alphaIIb-subunit (GPIIb) only when drug is present and closely mimic the behavior of antibodies found in human patients with quinine-induced thrombocytopenia in vitro and in vivo. Here, we demonstrate specific, high affinity binding of quinine to the complementarity-determining regions (CDR) of these antibodies and define in crystal structures the changes induced in the CDR by this interaction. Since in previous studies, no detectable binding of quinine to the target integrin could be demonstrated, the findings indicate that a hybrid paratope consisting of quinine and reconfigured antibody CDR plays a critical role in recognition of its target epitope by antibody and suggest that, in this type of drug-induced immunologic injury, the primary reaction involves binding of drug to antibody CDR, causing it to acquire specificity for a site on a platelet integrin.

-	~~The entry 4uin is ON HOLD until Paper Publication~~	+	Structural basis for quinine-dependent antibody binding to platelet integrin alphaIIbbeta3.,Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA Blood. 2015 Aug 17. pii: blood-2015-04-639351. PMID:26282540<ref>PMID:26282540</ref>

-	~~Authors: Zhu~~, J.~~, Zhu, J~~.~~, Bougie, D.W., Aster, R.H., Springer, T.A~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~crystal structure of quinine-dependent Fab 314.3 with quinine~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Bougie, D.W]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Aster, R H]]
		+	[[Category: Bougie, D W]]
		+	[[Category: Springer, T A]]
	[[Category: Zhu, J]]		[[Category: Zhu, J]]
-	[[Category: ~~Springer, T.A~~]]	+	[[Category: Immune system]]
-	[[Category: ~~Aster, R.H~~]]	+	[[Category: Mouse mab]]
		+	[[Category: Quinine-dependent]]

OCA at 09:18, 22 April 2015

2015-04-22T09:18:42Z

←Older revision		Revision as of 09:18, 22 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uin is ON HOLD	+	The entry 4uin is ON HOLD until Paper Publication

	Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.		Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.

OCA: Protected "4uin" [edit=sysop:move=sysop]

2015-04-15T09:12:47Z

Protected "4uin" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:12, 15 April 2015

OCA: New page: '''Unreleased structure''' The entry 4uin is ON HOLD Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. Description: crystal structure of quinine-dependent Fab 314.3 ...

2015-04-15T09:12:45Z

New page: '''Unreleased structure''' The entry 4uin is ON HOLD Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. Description: crystal structure of quinine-dependent Fab 314.3 ...

New page

'''Unreleased structure'''

The entry 4uin is ON HOLD

Authors: Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A.

Description: crystal structure of quinine-dependent Fab 314.3 with quinine
[[Category: Unreleased Structures]]
[[Category: Bougie, D.W]]
[[Category: Zhu, J]]
[[Category: Springer, T.A]]
[[Category: Aster, R.H]]