4uos - Revision history

OCA at 11:22, 9 May 2024

2024-05-09T11:22:00Z

←Older revision		Revision as of 11:22, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [https://pdbe.org/4uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [https://www.ebi.ac.uk/pdbsum/4uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [https://pdbe.org/4uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [https://www.ebi.ac.uk/pdbsum/4uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:29, 29 March 2023

2023-03-29T07:29:57Z

←Older revision		Revision as of 07:29, 29 March 2023
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	<StructureSection load='4uos' size='340' side='right'caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4uos' size='340' side='right'caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4UOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [https://pdbe.org/4uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [https://www.ebi.ac.uk/pdbsum/4uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [~~http~~://pdbe.org/4uos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4uos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Baker, D]]	+	[[Category: Baker D]]
-	[[Category: DiMaio, D]]	+	[[Category: DiMaio D]]
-	[[Category: Gonen, T]]	+	[[Category: Gonen T]]
-	[[Category: Huang, P]]	+	[[Category: Huang P]]
-	[[Category: Luisi~~, B F~~]]	+	[[Category: Luisi BF]]
-	[[Category: Nannenga, B]]	+	[[Category: Nannenga B]]
-	[[Category: Oberdorfer, G]]	+	[[Category: Oberdorfer G]]
-	[[Category: Pei~~, X Y~~]]	+	[[Category: Pei XY]]
-	[[Category: Rogers, J]]	+	[[Category: Rogers J]]
-	[[Category: Xu, C]]	+	[[Category: Xu C]]
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Protein design]]~~	+
-	~~[[Category: Thermodynamic hyperstability helical bundle~~]]	+

OCA at 08:43, 21 May 2019

2019-05-21T08:43:57Z

←Older revision		Revision as of 08:43, 21 May 2019
Line 1:		Line 1:

	==Thermodynamic hyperstability in parametrically designed helical bundles==		==Thermodynamic hyperstability in parametrically designed helical bundles==
-	<StructureSection load='4uos' size='340' side='right' caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='4uos' size='340' side='right'caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://pdbe.org/4uos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://pdbe.org/4uos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct sequences]]
	[[Category: Baker, D]]		[[Category: Baker, D]]
	[[Category: DiMaio, D]]		[[Category: DiMaio, D]]

OCA at 10:51, 11 August 2016

2016-08-11T10:51:12Z

←Older revision		Revision as of 10:51, 11 August 2016
Line 1:		Line 1:
		+
	==Thermodynamic hyperstability in parametrically designed helical bundles==		==Thermodynamic hyperstability in parametrically designed helical bundles==
	<StructureSection load='4uos' size='340' side='right' caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4uos' size='340' side='right' caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://pdbe.org/4uos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uos ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4uos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 19 November 2014

2014-11-19T10:50:45Z

←Older revision		Revision as of 10:50, 19 November 2014
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker, D.]]	+	[[Category: Baker, D]]
-	[[Category: DiMaio, D.]]	+	[[Category: DiMaio, D]]
-	[[Category: Gonen, T.]]	+	[[Category: Gonen, T]]
-	[[Category: Huang, P.]]	+	[[Category: Huang, P]]
-	[[Category: Luisi, B F.]]	+	[[Category: Luisi, B F]]
-	[[Category: Nannenga, B.]]	+	[[Category: Nannenga, B]]
-	[[Category: Oberdorfer, G.]]	+	[[Category: Oberdorfer, G]]
-	[[Category: Pei, X Y.]]	+	[[Category: Pei, X Y]]
-	[[Category: Rogers, J.]]	+	[[Category: Rogers, J]]
-	[[Category: Xu, C.]]	+	[[Category: Xu, C]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Protein design]]		[[Category: Protein design]]
	[[Category: Thermodynamic hyperstability helical bundle]]		[[Category: Thermodynamic hyperstability helical bundle]]

OCA at 08:50, 5 November 2014

2014-11-05T08:50:58Z

←Older revision		Revision as of 08:50, 5 November 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Thermodynamic hyperstability in parametrically designed helical bundles==
		+	<StructureSection load='4uos' size='340' side='right' caption='[[4uos]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UOS FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4uot\|4uot]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uos RCSB], [http://www.ebi.ac.uk/pdbsum/4uos PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe a procedure for designing proteins with backbones produced by varying the parameters in the Crick coiled coil-generating equations. Combinatorial design calculations identify low-energy sequences for alternative helix supercoil arrangements, and the helices in the lowest-energy arrangements are connected by loop building. We design an antiparallel monomeric untwisted three-helix bundle with 80-residue helices, an antiparallel monomeric right-handed four-helix bundle, and a pentameric parallel left-handed five-helix bundle. The designed proteins are extremely stable (extrapolated DeltaGfold > 60 kilocalories per mole), and their crystal structures are close to those of the design models with nearly identical core packing between the helices. The approach enables the custom design of hyperstable proteins with fine-tuned geometries for a wide range of applications.

-	~~The entry 4uos is ON HOLD until Paper Publication~~	+	High thermodynamic stability of parametrically designed helical bundles.,Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D Science. 2014 Oct 24;346(6208):481-5. doi: 10.1126/science.1257481. PMID:25342806<ref>PMID:25342806</ref>

-	~~Authors: Oberdorfer~~, G.~~, Huang, P~~.~~, Pei, X.Y~~., ~~Xu, C~~., Gonen, T., ~~Nannenga~~, B., ~~DiMaio~~, D., Rogers, J., ~~Luisi, B.F., Baker, D~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: Thermodynamic hyperstability ~~in parametrically designed~~ helical ~~bundles~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Baker, D.]]
		+	[[Category: DiMaio, D.]]
		+	[[Category: Gonen, T.]]
		+	[[Category: Huang, P.]]
		+	[[Category: Luisi, B F.]]
		+	[[Category: Nannenga, B.]]
		+	[[Category: Oberdorfer, G.]]
		+	[[Category: Pei, X Y.]]
		+	[[Category: Rogers, J.]]
		+	[[Category: Xu, C.]]
		+	[[Category: De novo protein]]
		+	[[Category: Protein design]]
		+	[[Category: Thermodynamic hyperstability helical bundle]]

OCA at 07:36, 2 July 2014

2014-07-02T07:36:36Z

←Older revision		Revision as of 07:36, 2 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4uos is ON HOLD	+	The entry 4uos is ON HOLD until Paper Publication

	Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.		Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.

	Description: Thermodynamic hyperstability in parametrically designed helical bundles		Description: Thermodynamic hyperstability in parametrically designed helical bundles

OCA: Protected "4uos" [edit=sysop:move=sysop]

2014-06-18T06:50:49Z

Protected "4uos" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 18 June 2014

OCA: New page: '''Unreleased structure''' The entry 4uos is ON HOLD Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D. Desc...

2014-06-18T06:50:48Z

New page: '''Unreleased structure''' The entry 4uos is ON HOLD Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D. Desc...

New page

'''Unreleased structure'''

The entry 4uos is ON HOLD

Authors: Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.

Description: Thermodynamic hyperstability in parametrically designed helical bundles